lamoTRIgine

ToxicologyAlso known as: LamictalAlso known as: 3,5-diamino-6-(2,3-dichlorophenyl)-1,2,4-triazineumol/L

Measures the concentration of the anticonvulsant medication lamotrigine in blood.

Normal Range

2.5 – 20 umol/L

umol/L

Abnormal Levels

Consult your provider

Specimen Type

Blood

Why This Biomarker Matters

Therapeutic drug monitoring ensures lamotrigine levels remain in the optimal range for seizure control and mood stabilization while minimizing side effects.

Understanding Your Results

Normal Range

2.5 – 20 umol/L

Overview

This test measures lamotrigine levels in blood. Lamotrigine is an anticonvulsant medication used to treat epilepsy and bipolar disorder. Maintaining therapeutic levels is essential for seizure control and mood stabilization. Blood level monitoring ensures the dose is adequate—too low and seizures may occur, too high and side effects like dizziness or tremor may develop. Regular monitoring helps optimize treatment effectiveness.

Research & Evidence

47 publications

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Reappraisal of Palinopsia as a Disregarded Symptom in Epilepsy: A Case Report and Systematic Review of the Related EEG Findings.

Clin EEG Neurosci · 2025

PMID: 40891739Review

Sex-specific elevated incidence of glaucoma associated with topiramate versus valproate or lamotrigine in epilepsy, not migraine: A population-based cohort study.

Epilepsia · 2026

PMID: 41518480Other

Risk of neurodevelopmental disorders after fetal topiramate exposure: a systematic review.

Front Drug Saf Regul · 2026

PMID: 41971010

Open-label randomised controlled trial of aripiprazole/sertraline combination in comparison with quetiapine for the clinical and cost-effectiveness of treatment of bipolar depression (the ASCEnD study): study protocol.

BMJ Open · 2026

PMID: 41856598

Lamotrigine-induced Stevens-Johnson syndrome: a systematic review of case reports and case series.

Clin Toxicol (Phila) · 2026

PMID: 41843406

Ketamine pharmacotherapy for major depressive disorder: A narrative review.

Prog Neuropsychopharmacol Biol Psychiatry · 2026

PMID: 41765199

Unveiling the degradation of lamotrigine in sulfate radical-mediated oxidation: kinetics, influencing factors and transformation mechanisms.

RSC Adv · 2026

PMID: 41909803

Pregnancy and epilepsy: pharmacokinetic insights into antiseizure medications.

Expert Opin Drug Metab Toxicol · 2026

PMID: 41863508

Should lamotrigine be discontinued before TMS treatment: A report of three cases.

Clin Neurophysiol · 2026

PMID: 41719897

Role of concomitant benzodiazepines, lithium, and lamotrigine in modulating the antidepressant effects of subcutaneous esketamine in patients with treatment-resistant depressive episodes: A retrospective naturalistic study.

J Affect Disord · 2026

PMID: 41933621

Research data from MEDLINE/PubMed · 47 articles

Technical Information (LOINC Codes)

Standardized laboratory codes for this biomarker

6948-4Primary

lamoTRIgine [Mass/volume] in Serum or Plasma

ug/mL

25458-1

lamoTRIgine [Moles/volume] in Serum or Plasma

umol/L

51982-7

lamoTRIgine [Presence] in Serum or Plasma

59920-9

lamoTRIgine [Moles/volume] in Gastric fluid

umol/L

60312-6

lamoTRIgine [Moles/volume] in Specimen

umol/L

98413-8

lamoTRIgine [Mass/volume] in Urine by Confirmatory method

ng/mL

98414-6

lamoTRIgine [Presence] in Urine by Confirmatory method

41761-8

lamoTRIgine [Mass/volume] in Serum or Plasma by Screen method

ug/mL

59919-1

lamoTRIgine [Moles/volume] in Urine

umol/L

Available Lab Tests

Order tests that measure this biomarker

Lamotrigine