Neutrophil cytoplasmic Ab.classic

Neutrophil cytoplasmic antibodies (c-ANCA) are autoimmune proteins where the body attacks its own cells. The classic pattern, also called c-ANCA, is strongly associated with granulomatosis with polyangiitis (GPA), a serious autoimmune disease affecting blood vessels. This test helps diagnose systemic vasculitis—inflammation of blood vessels throughout the body—which can damage organs like the lungs, kidneys, and sinuses. A positive c-ANCA, particularly with corresponding clinical symptoms, warrants further investigation and specialist evaluation to confirm diagnosis and initiate treatment.