Tumor necrosis factor.alpha

Tumor necrosis factor-alpha (TNF-α) is a powerful immune signaling molecule produced by white blood cells, particularly macrophages. While TNF-α plays an essential role fighting infection and removing damaged cells, chronically elevated levels drive systemic inflammation and disease. High TNF-α is linked to inflammatory conditions (rheumatoid arthritis, inflammatory bowel disease), chronic infections, and sepsis. The test helps assess inflammatory status and monitor response to anti-inflammatory medications, including TNF inhibitor drugs. Elevated levels indicate persistent immune activation requiring investigation and management.