Acquired hemophagocytic lymphohistiocytosis associated with malignant disease

disorder

SNOMED 782915004CUI C5190710

Overview

Acquired hemophagocytic lymphohistiocytosis associated with malignant disease is a disorder.

Auto-generated from clinical reference data. Not a substitute for medical advice.

Signs & Symptoms

Based on Human Phenotype Ontology (HPO) disease-phenotype annotations.

Hemophagocytosis

Always present (100%)HP:0012156

Abnormality of interleukin secretion

Very frequent (80-99%)HP:0011117

Elevated CRP

Very frequent (80-99%)HP:0011227

Increased ferritin

Very frequent (80-99%)HP:0003281

Large spleen

Very frequent (80-99%)HP:0001744

Pancytopenia

Very frequent (80-99%)HP:0001876

Pyrexia

Very frequent (80-99%)HP:0001945

Reduced total natural killer cell count

Very frequent (80-99%)HP:0040218

Renal functional abnormality

Very frequent (80-99%)HP:0012211

Unregulated immune response

Very frequent (80-99%)HP:0002958

Abnormal liver function tests

Frequent (30-79%)HP:0002910

Blood tumor

Frequent (30-79%)HP:0004377

High blood bilirubin levels

Frequent (30-79%)HP:0002904

Increased lactate dehydrogenase level

Frequent (30-79%)HP:0025435

Increased triglycerides

Frequent (30-79%)HP:0002155

Low fibrinogen level

Frequent (30-79%)HP:0011900

Low number of red blood cells or haemoglobin

Frequent (30-79%)HP:0001903

Neutropoenia

Frequent (30-79%)HP:0001875

Thrombocytopenia

Frequent (30-79%)HP:0001873

Acute lymphocytic leukemia

Occasional (5-29%)HP:0006721

Acute myeloid leukaemia

Occasional (5-29%)HP:0004808

B-cell lymphoma

Occasional (5-29%)HP:0012191

Burkitt lymphoma

Occasional (5-29%)HP:0030080

Cerebrospinal fluid pleocytosis

Occasional (5-29%)HP:0012229

Disseminated intravascular coagulation

Occasional (5-29%)HP:0005521

Elevated csf protein

Occasional (5-29%)HP:0002922

Hepatic insufficiency

Occasional (5-29%)HP:0001399

Hepatosplenomegaly

Occasional (5-29%)HP:0001433

Hodgkin's lymphoma

Occasional (5-29%)HP:0012189

Hypoplastic myelodysplasia

Occasional (5-29%)HP:0002863

Related Conditions

Secondary hemophagocytic lymphohistiocytosis(parent)

Malignant white blood cell disorder(parent)

Quick Facts

SNOMED CT: 782915004
UMLS CUI: C5190710
Fully Specified Name: Acquired hemophagocytic lymphohistiocytosis associated with malignant disease (disorder)
Specialists: 0
Diagnostic Biomarkers: 0
HPO Phenotypes: 30

Medical Disclaimer

This information is for educational purposes only and does not constitute medical advice, diagnosis, or treatment. Always consult with a qualified healthcare provider regarding any medical condition or treatment plan.

Clinical content is derived from the SNOMED CT clinical ontology and curated medical knowledge graphs.