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Autosomal dominant spastic paraplegia type 4

disorder
SNOMED 723820001CUI C1866855

Overview

Autosomal dominant spastic paraplegia type 4 is a disorder.

Auto-generated from clinical reference data. Not a substitute for medical advice.

Signs & Symptoms

Based on Human Phenotype Ontology (HPO) disease-phenotype annotations.

Ankle clonus
Frequent (30-79%)HP:0011448
Brisk deep tendon reflexes
Frequent (30-79%)HP:0001348
Decreased vibration sense in feet
Frequent (30-79%)HP:0006938
Extensor plantar responses
Frequent (30-79%)HP:0003487
Functional motor deficit
Frequent (30-79%)HP:0004302
Involuntary muscle stiffness, contraction, or spasm
Frequent (30-79%)HP:0001257
Leg muscle stiffness
Frequent (30-79%)HP:0008969
Lower limb muscle weakness
Frequent (30-79%)HP:0007340
Spasticity of lower limb
Frequent (30-79%)HP:0002061
Urgency frequency syndrome
Frequent (30-79%)HP:0000012
Cognitive deficits
Occasional (5-29%)HP:0100543
Difficulty articulating speech
Occasional (5-29%)HP:0001260
Distal muscle atrophy, upper and lower limbs
Occasional (5-29%)HP:0003693
Pes cavus
Occasional (5-29%)HP:0001761
Sphincter disturbances
Occasional (5-29%)HP:0002839
Upper limb hyperreflexia
Occasional (5-29%)HP:0007350
Ataxia
Very rare (1-4%)HP:0001251
Epilepsy
Very rare (1-4%)HP:0001250
Mental deficiency
Very rare (1-4%)HP:0001249
Degeneration of the lateral corticospinal tracts
HP:0002314
Depression
HP:0000716
Distal sensory loss, especially vibratory sense
HP:0002166
Impulse control disorders
HP:0000734
Increased reflexes
HP:0001347
Involuntary, rapid, rhythmic eye movements
HP:0000639
Lack of feeling, emotion, interest
HP:0000741
Leg paralysis
HP:0010550
Low back pain
HP:0003419
Memory loss
HP:0002354
physical aggression
HP:0000718

Related Conditions

Autosomal dominant hereditary spastic paraplegia(parent)

Quick Facts

SNOMED CT
723820001
UMLS CUI
C1866855
Fully Specified Name
Autosomal dominant spastic paraplegia type 4 (disorder)
Specialists
0
Diagnostic Biomarkers
0
HPO Phenotypes
30
Medical Disclaimer

This information is for educational purposes only and does not constitute medical advice, diagnosis, or treatment. Always consult with a qualified healthcare provider regarding any medical condition or treatment plan.

Clinical content is derived from the SNOMED CT clinical ontology and curated medical knowledge graphs.