Autosomal dominant spastic paraplegia type 42

disorder

SNOMED 763070001CUI C2675528

Overview

Autosomal dominant spastic paraplegia type 42 is a disorder.

Auto-generated from clinical reference data. Not a substitute for medical advice.

Signs & Symptoms

Based on Human Phenotype Ontology (HPO) disease-phenotype annotations.

Degeneration of the lateral corticospinal tracts

Very frequent (80-99%)HP:0002314

Extensor plantar responses

Very frequent (80-99%)HP:0003487

Increased reflexes

Very frequent (80-99%)HP:0001347

Lower limb hypertonia

Very frequent (80-99%)HP:0006895

Progressive spastic paraplegia

Very frequent (80-99%)HP:0007020

Spastic walk

Very frequent (80-99%)HP:0002064

Spasticity of lower limb

Very frequent (80-99%)HP:0002061

Clonus

Frequent (30-79%)HP:0002169

Distal sensory loss, especially vibratory sense

Frequent (30-79%)HP:0002166

Lower limb amyotrophy

Frequent (30-79%)HP:0007210

Lower limb muscle weakness

Frequent (30-79%)HP:0007340

Spinal cord lesion

Frequent (30-79%)HP:0100561

Pes cavus

Occasional (5-29%)HP:0001761

Lower limb hyperreflexia

HP:0002395

Muscle degeneration

HP:0003202

Muscle weakness

HP:0001324

Spastic paraplegia

HP:0001258

Related Conditions

Pure hereditary spastic paraplegia(parent)

Autosomal dominant hereditary spastic paraplegia(parent)

Quick Facts

SNOMED CT: 763070001
UMLS CUI: C2675528
Fully Specified Name: Autosomal dominant spastic paraplegia type 42 (disorder)
Specialists: 0
Diagnostic Biomarkers: 0
HPO Phenotypes: 17

Medical Disclaimer

This information is for educational purposes only and does not constitute medical advice, diagnosis, or treatment. Always consult with a qualified healthcare provider regarding any medical condition or treatment plan.

Clinical content is derived from the SNOMED CT clinical ontology and curated medical knowledge graphs.