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Autosomal dominant spastic paraplegia type 8
disorderSNOMED 785305006CUI C1863704
Overview
Autosomal dominant spastic paraplegia type 8 is a disorder.
Auto-generated from clinical reference data. Not a substitute for medical advice.
Signs & Symptoms
Based on Human Phenotype Ontology (HPO) disease-phenotype annotations.
Lower limb hyperreflexia
Always present (100%)HP:0002395
Spastic paraplegia
Always present (100%)HP:0001258
Degeneration of the lateral corticospinal tracts
Very frequent (80-99%)HP:0002314
Extensor plantar responses
Very frequent (80-99%)HP:0003487
Gait disturbance
Very frequent (80-99%)HP:0001288
Increased reflexes
Very frequent (80-99%)HP:0001347
Progressive spastic paraplegia
Very frequent (80-99%)HP:0007020
Spasticity of lower limb
Very frequent (80-99%)HP:0002061
Upper limb hyperreflexia
Very frequent (80-99%)HP:0007350
Appendicular ataxia
Frequent (30-79%)HP:0002070
Deglutition disorder
Frequent (30-79%)HP:0002015
Distal sensory loss, especially vibratory sense
Frequent (30-79%)HP:0002166
Low back pain
Frequent (30-79%)HP:0003419
Lower limb muscle weakness
Frequent (30-79%)HP:0007340
Muscle spasm
Frequent (30-79%)HP:0003394
Overactive bladder
Frequent (30-79%)HP:0000012
Peroneal muscle atrophy
Frequent (30-79%)HP:0009049
Pes cavus
Frequent (30-79%)HP:0001761
Spastic walk
Frequent (30-79%)HP:0002064
Spinal cord lesion
Frequent (30-79%)HP:0100561
Uncoordinated limb movement
Frequent (30-79%)HP:0002406
Urinary incontinence
Frequent (30-79%)HP:0000020
Clonus
Occasional (5-29%)HP:0002169
Upper extremity spasticity
Occasional (5-29%)HP:0006986
Difficulty articulating speech
Excluded (<1%)HP:0001260
Sphincter disturbances
HP:0002839
Related Conditions
Quick Facts
- SNOMED CT
- 785305006
- UMLS CUI
- C1863704
- Fully Specified Name
- Autosomal dominant spastic paraplegia type 8 (disorder)
- Specialists
- 0
- Diagnostic Biomarkers
- 0
- HPO Phenotypes
- 26
Medical Disclaimer
This information is for educational purposes only and does not constitute medical advice, diagnosis, or treatment. Always consult with a qualified healthcare provider regarding any medical condition or treatment plan.
Clinical content is derived from the SNOMED CT clinical ontology and curated medical knowledge graphs.