Combined immunodeficiency due to DOCK8 deficiency

disorder

SNOMED 1197205005CUI C4722305

Overview

Combined immunodeficiency due to DOCK8 deficiency is a disorder.

Auto-generated from clinical reference data. Not a substitute for medical advice.

Signs & Symptoms

Based on Human Phenotype Ontology (HPO) disease-phenotype annotations.

Decreased circulating total IgM

Always present (100%)HP:0002850

Decreased proportion of CD4-positive T cells

Always present (100%)HP:0032218

Prone to bacterial infection

Always present (100%)HP:0002718

B cell lymphopenia

Very frequent (80-99%)HP:0010976

Bronchial asthma

Very frequent (80-99%)HP:0002099

Chronic ear infection

Very frequent (80-99%)HP:0000389

Eczema

Very frequent (80-99%)HP:0000964

Eosinophilia

Very frequent (80-99%)HP:0001880

High immunoglobulin E

Very frequent (80-99%)HP:0003212

Infantile eczema

Very frequent (80-99%)HP:0001047

Onychomycosis

Very frequent (80-99%)HP:0012203

Open skin sore

Very frequent (80-99%)HP:0200042

Pneumonia

Very frequent (80-99%)HP:0002090

Reaction to food allergens

Very frequent (80-99%)HP:0500093

Recurrent bacterial skin infections

Very frequent (80-99%)HP:0005406

Recurrent candida infections

Very frequent (80-99%)HP:0005401

Recurrent middle ear infection

Very frequent (80-99%)HP:0000403

Recurrent sinus disease

Very frequent (80-99%)HP:0011108

Recurrent viral infections

Very frequent (80-99%)HP:0004429

Reduced number of T cells

Very frequent (80-99%)HP:0005403

respiratory infections, recurrent

Very frequent (80-99%)HP:0002205

Skin abscess

Very frequent (80-99%)HP:0031292

Warts

Very frequent (80-99%)HP:0200043

Bronchiectasis

Frequent (30-79%)HP:0002110

Disseminated molluscum contagiosum

Frequent (30-79%)HP:0032185

Increased total IgG in blood

Frequent (30-79%)HP:0003237

Molluscum contagiosum

Frequent (30-79%)HP:0032163

Poor weight gain

Frequent (30-79%)HP:0001508

pulmonary infections, recurrent

Frequent (30-79%)HP:0006532

Reduced total natural killer cell count

Frequent (30-79%)HP:0040218

Related Conditions

Combined immunodeficiency disease(parent)

Recessive hereditary disorder (autosomal)(parent)

Quick Facts

SNOMED CT: 1197205005
UMLS CUI: C4722305
Fully Specified Name: Combined immunodeficiency due to dedicator of cytokinesis 8 deficiency (disorder)
Specialists: 0
Diagnostic Biomarkers: 0
HPO Phenotypes: 30

Medical Disclaimer

This information is for educational purposes only and does not constitute medical advice, diagnosis, or treatment. Always consult with a qualified healthcare provider regarding any medical condition or treatment plan.

Clinical content is derived from the SNOMED CT clinical ontology and curated medical knowledge graphs.