Crouzon syndrome

disorder

SNOMED 28861008CUI C0010273

Overview

Source: MedlinePlus.gov, National Library of Medicine. Not a substitute for medical advice.

Research Evidence

Peer-reviewed studies linked via MeSH term "Craniofacial Dysostoses" from the MEDLINE/PubMed database.

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Prevalence and Patterns of Permanent Tooth Agenesis in Patients With Crouzon or Apert Syndrome: A Systematic Review and Meta-Analysis.

[object Object], [object Object], [object Object] et al. · Orthod Craniofac Res · 2026

PMID: 41085212Meta-AnalysisFull text (PMC)

Complications of frontofacial advancement.

[object Object], [object Object], [object Object] et al. · Childs Nerv Syst · 2012

PMID: 22872275Meta-Analysis

Conventional transarterial chemoembolization combined with systemic therapy versus systemic therapy alone as second-line treatment for unresectable colorectal liver metastases: randomized clinical trial.

[object Object], [object Object], [object Object] et al. · Br J Surg · 2021

PMID: 33611431RCT

Growth of the orbit after frontoorbital advancement using nonrigid suture vs rigid plate fixation technique.

[object Object], [object Object], [object Object] et al. · J Pediatr Surg · 2008

PMID: 18970943RCT

Midface osteotomy versus distraction: the effect on speech, nasality, and velopharyngeal function in craniofacial dysostosis.

[object Object], [object Object], [object Object] et al. · Cleft Palate Craniofac J · 2008

PMID: 18616366RCT

Ocular manifestations and treatment progress of Crouzon syndrome.

[object Object], [object Object], [object Object] · Int Ophthalmol · 2024

PMID: 39235629Review

Squamosal Suture Synostosis: An Under-Recognized Phenomenon.

[object Object], [object Object], [object Object] et al. · Cleft Palate Craniofac J · 2023

PMID: 35593077Review

The diagnosis and treatment of infant Crouzon syndrome with literature review.

[object Object], [object Object], [object Object] et al. · Asian J Surg · 2022

PMID: 35232642Review

Subcranial Midface Advancement in Patients with Syndromic Craniosynostosis.

[object Object], [object Object], [object Object] et al. · Oral Maxillofac Surg Clin North Am · 2022

PMID: 35787822Review

Crouzon syndrome and the eye: An overview.

[object Object], [object Object], [object Object] et al. · Indian J Ophthalmol · 2022

PMID: 35791116ReviewFull text (PMC)

Search all PubMed articles for Crouzon syndrome

Research data from MEDLINE/PubMed

Signs & Symptoms

Based on Human Phenotype Ontology (HPO) disease-phenotype annotations.

Abnormality of the skull bones

Very frequent (80-99%)HP:0000929

Dysmorphic facies

Very frequent (80-99%)HP:0001999

Frontal protuberance

Very frequent (80-99%)HP:0002007

High forehead

Very frequent (80-99%)HP:0000348

Multisutural craniosynostosis

Very frequent (80-99%)HP:0011324

Chiari malformation

Frequent (30-79%)HP:0002308

Conjunctivitis, recurrent

Frequent (30-79%)HP:0000509

Decreased projection of midface

Frequent (30-79%)HP:0011800

Deficiency of upper jaw bones

Frequent (30-79%)HP:0000327

Eyelid ptosis

Frequent (30-79%)HP:0000508

Hearing loss, conductive

Frequent (30-79%)HP:0000405

Increased distance between eyes

Frequent (30-79%)HP:0000316

Intracranial hypertension

Frequent (30-79%)HP:0002516

Protruding eyes

Frequent (30-79%)HP:0000520

Short and broad skull

Frequent (30-79%)HP:0000248

Small cerebellum

Frequent (30-79%)HP:0001321

Squint

Frequent (30-79%)HP:0000486

Tall shaped head

Frequent (30-79%)HP:0000262

Abnormality of the sacrum

Occasional (5-29%)HP:0005107

Acanthosis nigricans

Occasional (5-29%)HP:0000956

Choanal atresia

Occasional (5-29%)HP:0000453

Headache

Occasional (5-29%)HP:0002315

Hearing impairment

Occasional (5-29%)HP:0000365

Hooked nose

Occasional (5-29%)HP:0000444

Hypopigmented skin patches

Occasional (5-29%)HP:0001053

Iris coloboma

Occasional (5-29%)HP:0000612

Narrow internal auditory canal

Occasional (5-29%)HP:0011386

Narrow palate

Occasional (5-29%)HP:0000189

Noncancerous mole

Occasional (5-29%)HP:0000995

Nonsyndromal hydrocephalus

Occasional (5-29%)HP:0000238

Related Conditions

Crouzon syndrome with acanthosis nigricans(child)

Craniosynostosis syndrome(parent)

Autosomal dominant hereditary disorder(parent)

Multiple malformation syndrome with facial defects as major feature(parent)

Hereditary disorder of musculoskeletal system(parent)

Developmental hereditary disorder(parent)

Quick Facts

SNOMED CT: 28861008
UMLS CUI: C0010273
Fully Specified Name: Crouzon syndrome (disorder)
Specialists: 0
Diagnostic Biomarkers: 0
HPO Phenotypes: 30

Medical Disclaimer

This information is for educational purposes only and does not constitute medical advice, diagnosis, or treatment. Always consult with a qualified healthcare provider regarding any medical condition or treatment plan.

Clinical content is derived from the SNOMED CT clinical ontology and curated medical knowledge graphs.