Fibrous histiocytoma of tendon sheath

disorder

SNOMED 310605004CUI C1318543

Overview

Source: MedlinePlus.gov, National Library of Medicine. Not a substitute for medical advice.

Treatments & Interventions

Pexidartinib

substance

Research Evidence

Peer-reviewed studies linked via MeSH term "Giant Cell Tumor of Tendon Sheath" from the MEDLINE/PubMed database.

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Management of tenosynovial giant cell tumour of the temporomandibular joint: a systematic review.

[object Object], [object Object], [object Object] · ANZ J Surg · 2023

PMID: 37052058Meta-Analysis

Update on Tenosynovial Giant Cell Tumor, an Inflammatory Arthritis With Neoplastic Features.

[object Object], [object Object], [object Object] · Front Immunol · 2022

PMID: 35265077Meta-AnalysisFull text (PMC)

Treatment, recurrence rates and follow-up of Tenosynovial Giant Cell Tumor (TGCT) of the foot and ankle-A systematic review and meta-analysis.

[object Object], [object Object], [object Object] et al. · PLoS One · 2021

PMID: 34855875Meta-AnalysisFull text (PMC)

Arthroscopic Versus Open Management of Diffuse-Type Tenosynovial Giant Cell Tumor of the Knee: A Meta-analysis of Retrospective Cohort Studies.

[object Object], [object Object], [object Object] et al. · J Am Acad Orthop Surg Glob Res Rev · 2021

PMID: 34882586Meta-AnalysisFull text (PMC)

Pexidartinib, a Novel Small Molecule CSF-1R Inhibitor in Use for Tenosynovial Giant Cell Tumor: A Systematic Review of Pre-Clinical and Clinical Development.

[object Object], [object Object], [object Object] et al. · Drug Des Devel Ther · 2020

PMID: 32440095Meta-AnalysisFull text (PMC)

Management of Tenosynovial Giant Cell Tumor: A Neoplastic and Inflammatory Disease.

[object Object], [object Object], [object Object] · J Am Acad Orthop Surg Glob Res Rev · 2020

PMID: 33156160Meta-AnalysisFull text (PMC)

Giant cell tumor of tendon sheath: Open surgery or arthroscopic synovectomy? A systematic review of the literature.

[object Object], [object Object], [object Object] et al. · Orthop Traumatol Surg Res · 2017

PMID: 28428036Meta-Analysis

Long-term efficacy and safety of pexidartinib in patients with tenosynovial giant cell tumor: final results of the ENLIVEN study.

[object Object], [object Object], [object Object] et al. · Oncologist · 2025

PMID: 40613752RCTFull text (PMC)

Vimseltinib versus placebo for tenosynovial giant cell tumour (MOTION): a multicentre, randomised, double-blind, placebo-controlled, phase 3 trial.

[object Object], [object Object], [object Object] et al. · Lancet · 2024

PMID: 38843860RCTFull text (PMC)

Pexidartinib Provides Modest Pain Relief in Patients With Tenosynovial Giant Cell Tumor: Results From ENLIVEN.

[object Object], [object Object], [object Object] et al. · Clin Orthop Relat Res · 2023

PMID: 36001000RCTFull text (PMC)

Search all PubMed articles for Fibrous histiocytoma of tendon sheath

Research data from MEDLINE/PubMed

Signs & Symptoms

Based on Human Phenotype Ontology (HPO) disease-phenotype annotations.

Arthralgias

Very frequent (80-99%)HP:0002829

Abnormality of the knee

Frequent (30-79%)HP:0002815

Arthritis

Frequent (30-79%)HP:0001369

Breakdown of bone

Frequent (30-79%)HP:0002797

Joint hemorrhage

Frequent (30-79%)HP:0005261

Joint swelling

Frequent (30-79%)HP:0001386

Limitation of joint mobility

Frequent (30-79%)HP:0001376

Stiff joint

Frequent (30-79%)HP:0001387

Abnormal temporal bone morphology

Occasional (5-29%)HP:0009911

Abnormal tympanic membrane morphology

Occasional (5-29%)HP:0040090

Abnormality of the ankle

Occasional (5-29%)HP:0003028

Abnormality of the auditory canal

Occasional (5-29%)HP:0000372

Abnormality of the elbow

Occasional (5-29%)HP:0009811

Abnormality of the hip joints

Occasional (5-29%)HP:0001384

Abnormality of the shoulder

Occasional (5-29%)HP:0003043

Abnormality of the wrist

Occasional (5-29%)HP:0003019

Groin pain

Occasional (5-29%)HP:0031520

Hearing loss, conductive

Occasional (5-29%)HP:0000405

Multiple lentigines

Occasional (5-29%)HP:0001003

Onset of lymphedema around puberty

Occasional (5-29%)HP:0001004

Calcium deposits in joints

Very rare (1-4%)HP:0000934

Localized osteoporosis

Very rare (1-4%)HP:0040161

Polyarticular arthropathy

Very rare (1-4%)HP:0005195

Synovial lining hyperplasia

Very rare (1-4%)HP:0005186

Related Conditions

Tendon sheath disorder(parent)

Neoplasm of musculoskeletal system(parent)

Benign neoplasm of soft tissues(parent)

Quick Facts

SNOMED CT: 310605004
UMLS CUI: C1318543
Fully Specified Name: Fibrous histiocytoma of tendon sheath (disorder)
Specialists: 0
Diagnostic Biomarkers: 0
HPO Phenotypes: 24
Known Treatments: 1

Medical Disclaimer

This information is for educational purposes only and does not constitute medical advice, diagnosis, or treatment. Always consult with a qualified healthcare provider regarding any medical condition or treatment plan.

Clinical content is derived from the SNOMED CT clinical ontology and curated medical knowledge graphs.