Lower motor neuron syndrome with late-adult onset

disorder

SNOMED 783618006CUI C5191007

Overview

Lower motor neuron syndrome with late-adult onset is a disorder.

Auto-generated from clinical reference data. Not a substitute for medical advice.

Signs & Symptoms

Based on Human Phenotype Ontology (HPO) disease-phenotype annotations.

Distal muscle weakness in lower limbs

Very frequent (80-99%)HP:0009053

Areflexia

Frequent (30-79%)HP:0001284

Calf muscle pain

Frequent (30-79%)HP:0031921

Cold-induced muscle cramps

Frequent (30-79%)HP:0003449

Elevated circulating creatine phosphokinase

Frequent (30-79%)HP:0003236

EMG: neuropathic changes

Frequent (30-79%)HP:0003445

Gait disturbance

Frequent (30-79%)HP:0001288

Hyporeflexia

Frequent (30-79%)HP:0001265

Increased intramuscular fat

Frequent (30-79%)HP:0008985

Muscle cramps with exertion

Frequent (30-79%)HP:0003710

Muscle fasciculation

Frequent (30-79%)HP:0002380

Proximal muscle weakness in lower limbs

Frequent (30-79%)HP:0008994

Abnormal sensory nerve conduction velocity

Occasional (5-29%)HP:0040132

Decreased distal vibration sense

Occasional (5-29%)HP:0006886

Deglutition disorder

Occasional (5-29%)HP:0002015

EMG: myopathic changes

Occasional (5-29%)HP:0003458

Intrinsic hand muscle atrophy

Occasional (5-29%)HP:0008954

Proximal muscle weakness in upper limbs

Occasional (5-29%)HP:0008997

Ragged-red muscle fibers

Occasional (5-29%)HP:0003200

Rimmed vacuoles

Occasional (5-29%)HP:0003805

Tongue fasciculations/fibrillations

Occasional (5-29%)HP:0001308

Tremor

Occasional (5-29%)HP:0001337

Abnormality of the respiratory system

Very rare (1-4%)HP:0002086

Bulbar signs

Very rare (1-4%)HP:0002483

Inability to walk

Very rare (1-4%)HP:0002540

Related Conditions

Spinal muscular atrophy(parent)

Autosomal dominant hereditary disorder(parent)

Quick Facts

SNOMED CT: 783618006
UMLS CUI: C5191007
Fully Specified Name: Lower motor neuron syndrome with late-adult onset (disorder)
Specialists: 0
Diagnostic Biomarkers: 0
HPO Phenotypes: 25

Medical Disclaimer

This information is for educational purposes only and does not constitute medical advice, diagnosis, or treatment. Always consult with a qualified healthcare provider regarding any medical condition or treatment plan.

Clinical content is derived from the SNOMED CT clinical ontology and curated medical knowledge graphs.