Signs & Symptoms
Based on Human Phenotype Ontology (HPO) disease-phenotype annotations.
Peripheral nerve disease
Always present (100%)HP:0001271
Abnormality of skin physiology
Very frequent (80-99%)HP:0011122
Abnormality of the endocrine system
Very frequent (80-99%)HP:0000818
Decreased activity of gonads
Very frequent (80-99%)HP:0000135
Elevated immunoglobulin levels
Very frequent (80-99%)HP:0010702
Lymphoproliferative disorders
Very frequent (80-99%)HP:0005523
Visceromegaly
Very frequent (80-99%)HP:0003271
Abnormal erection
Frequent (30-79%)HP:0100639
Absent deep tendon reflexes
Frequent (30-79%)HP:0001284
Adrenocortical insufficiency
Frequent (30-79%)HP:0008207
Ascites
Frequent (30-79%)HP:0001541
Clubbing of fingers
Frequent (30-79%)HP:0100759
Diabetes mellitus
Frequent (30-79%)HP:0000819
Diffusely thickened skin
Frequent (30-79%)HP:0001072
Edema
Frequent (30-79%)HP:0000969
Elevated circulating VEGF concentration
Frequent (30-79%)HP:0031052
Enlarged liver
Frequent (30-79%)HP:0002240
Fluid around lungs
Frequent (30-79%)HP:0002202
Generalised sclerosis of hand bones
Frequent (30-79%)HP:0004054
Gynaecomastia
Frequent (30-79%)HP:0000771
Hemangiomata
Frequent (30-79%)HP:0001028
Hyperostosis of skull base
Frequent (30-79%)HP:0002694
Hypothyroidism
Frequent (30-79%)HP:0000821
Increased bone density in wide portion of long bone
Frequent (30-79%)HP:0004979
Increased hair growth on body
Frequent (30-79%)HP:0000998
Large spleen
Frequent (30-79%)HP:0001744
Lymph node hyperplasia
Frequent (30-79%)HP:0002716
Melanoderma
Frequent (30-79%)HP:0000953
Muscle weakness
Frequent (30-79%)HP:0001324
Pain
Frequent (30-79%)HP:0012531
Quick Facts
- SNOMED CT
- 79268002
- UMLS CUI
- C0085404
- Fully Specified Name
- Polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, and skin changes syndrome (disorder)
- Specialists
- 0
- Diagnostic Biomarkers
- 0
- HPO Phenotypes
- 30
Medical Disclaimer
This information is for educational purposes only and does not constitute medical advice, diagnosis, or treatment. Always consult with a qualified healthcare provider regarding any medical condition or treatment plan.
Clinical content is derived from the SNOMED CT clinical ontology and curated medical knowledge graphs.