Overview
Primary lateral sclerosis is a disorder.
Auto-generated from clinical reference data. Not a substitute for medical advice.
Signs & Symptoms
Based on Human Phenotype Ontology (HPO) disease-phenotype annotations.
Abnormal shape of upper motor neuron
Very frequent (80-99%)HP:0002127
Extensor plantar responses
Very frequent (80-99%)HP:0003487
Generalised hyperreflexia
Very frequent (80-99%)HP:0007034
Involuntary muscle stiffness, contraction, or spasm
Very frequent (80-99%)HP:0001257
Pyramidal tract dysfunction
Very frequent (80-99%)HP:0002493
Abnormality of balance
Frequent (30-79%)HP:0002141
Deglutition disorder
Frequent (30-79%)HP:0002015
EMG: chronic denervation signs
Frequent (30-79%)HP:0003444
Hoffmann's sign
Frequent (30-79%)HP:0031993
Impaired smooth pursuit
Frequent (30-79%)HP:0007772
Incoordination
Frequent (30-79%)HP:0002311
Loss of speech
Frequent (30-79%)HP:0002371
Overactive bladder
Frequent (30-79%)HP:0000012
Progressive spastic paraparesis
Frequent (30-79%)HP:0007199
Pseudobulbar symptoms
Frequent (30-79%)HP:0002200
Rigid dysarthria
Frequent (30-79%)HP:0002464
Spastic walk
Frequent (30-79%)HP:0002064
Weakness due to upper motor neuron dysfunction
Frequent (30-79%)HP:0010549
Cervical spinal cord atrophy
Occasional (5-29%)HP:0010873
Degeneration of the spinal cord
Occasional (5-29%)HP:0006827
Intellectual impairment
Occasional (5-29%)HP:0100543
Length dependent motor neuropathy
Occasional (5-29%)HP:0007002
Nasal speech
Occasional (5-29%)HP:0001611
Quick Facts
- SNOMED CT
- 81211007
- UMLS CUI
- C0154682
- Fully Specified Name
- Primary lateral sclerosis (disorder)
- Specialists
- 0
- Diagnostic Biomarkers
- 0
- HPO Phenotypes
- 23
Medical Disclaimer
This information is for educational purposes only and does not constitute medical advice, diagnosis, or treatment. Always consult with a qualified healthcare provider regarding any medical condition or treatment plan.
Clinical content is derived from the SNOMED CT clinical ontology and curated medical knowledge graphs.