Overview
Progressive multifocal leukoencephalopathy is a disorder.
Auto-generated from clinical reference data. Not a substitute for medical advice.
Signs & Symptoms
Based on Human Phenotype Ontology (HPO) disease-phenotype annotations.
Abnormal astrocyte morphology
Very frequent (80-99%)HP:0100707
Abnormal CD4+ T cell subset proportion
Very frequent (80-99%)HP:0031392
Abnormal cerebrospinal fluid morphology
Very frequent (80-99%)HP:0002921
Abnormal oligodendroglia morphology
Very frequent (80-99%)HP:0100706
Brain and/or spinal cord issue
Very frequent (80-99%)HP:0000707
Demyelination in central white matter
Very frequent (80-99%)HP:0007305
Functional motor deficit
Very frequent (80-99%)HP:0004302
Immune deficiency
Very frequent (80-99%)HP:0002721
Abnormal vocalization
Frequent (30-79%)HP:0002167
Cognitive deficits
Frequent (30-79%)HP:0100543
Decreased proportion of CD8-positive T cells
Frequent (30-79%)HP:0005415
Difficulty articulating speech
Frequent (30-79%)HP:0001260
Headache
Frequent (30-79%)HP:0002315
Inability to coordinate movements when walking
Frequent (30-79%)HP:0002066
Intellectual deterioration
Frequent (30-79%)HP:0001268
Limb muscle weakness
Frequent (30-79%)HP:0003690
Paralysis or weakness of one side of body
Frequent (30-79%)HP:0004374
Poor vision
Frequent (30-79%)HP:0000505
Sensory impairment
Frequent (30-79%)HP:0003474
Weakness due to upper motor neuron dysfunction
Frequent (30-79%)HP:0010549
Blood tumor
Occasional (5-29%)HP:0004377
Difficulty finding words
Occasional (5-29%)HP:0002381
Homonymous hemianopia
Occasional (5-29%)HP:0030516
Involuntary, rapid, rhythmic eye movements
Occasional (5-29%)HP:0000639
Oculomotor neuropathy
Occasional (5-29%)HP:0012246
Parkinsonian disease
Occasional (5-29%)HP:0001300
Partial loss of field of vision
Occasional (5-29%)HP:0001123
Personality changes
Occasional (5-29%)HP:0000751
Seizures
Occasional (5-29%)HP:0001250
Self-neglect
Occasional (5-29%)HP:0025479
Related Conditions
Leukoencephalopathy with brainstem and spinal cord involvement and lactate elevation(child)
Progressive multifocal leucoencephalopathy co-occurrent with human immunodeficiency virus infection(child)
Dementia with progressive multifocal leukoencephalopathy(child)
Disease caused by JC polyomavirus(parent)
Viral disease of central nervous system(parent)
White matter disease(parent)
White matter disorder caused by infection(parent)
Quick Facts
- SNOMED CT
- 22255007
- UMLS CUI
- C0023524
- Fully Specified Name
- Progressive multifocal leukoencephalopathy (disorder)
- Specialists
- 0
- Diagnostic Biomarkers
- 0
- HPO Phenotypes
- 30
Medical Disclaimer
This information is for educational purposes only and does not constitute medical advice, diagnosis, or treatment. Always consult with a qualified healthcare provider regarding any medical condition or treatment plan.
Clinical content is derived from the SNOMED CT clinical ontology and curated medical knowledge graphs.