Overview
Serotonin syndrome is a disorder.
Auto-generated from clinical reference data. Not a substitute for medical advice.
Research Evidence
Peer-reviewed studies linked via MeSH term "Serotonin Syndrome" from the MEDLINE/PubMed database.
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Review article: Efficacy of cyproheptadine in the management of serotonin toxicity following deliberate self-poisoning - A systematic review.
[object Object], [object Object] · Emerg Med Australas · 2025
PMID: 39791184Meta-Analysis
A Translational Model-Based Meta-Analysis to Predict Tremor Incidence Associated with Serotonin Reuptake Transporter Inhibition.
[object Object], [object Object], [object Object] et al. · Clin Pharmacol Ther · 2025
PMID: 40304421Meta-Analysis
Linezolid-associated serotonin toxicity: a systematic review.
[object Object], [object Object] · Eur J Clin Pharmacol · 2023
PMID: 37129603Meta-Analysis
Dexmedetomidine in the treatment of toxicologic conditions: a systematic review and review of the toxicology investigators consortium database.
[object Object], [object Object], [object Object] et al. · Clin Toxicol (Phila) · 2022
PMID: 36346349Meta-Analysis
Safety of Ketamine Augmentation to Monoamine Oxidase Inhibitors in Treatment-Resistant Depression: A Systematic Literature Review and Case Series.
[object Object], [object Object], [object Object] et al. · J Clin Psychiatry · 2022
PMID: 36300995Meta-Analysis
Fatal serotonin syndrome: a systematic review of 56 cases in the literature.
[object Object], [object Object], [object Object] et al. · Clin Toxicol (Phila) · 2021
PMID: 33196298Meta-Analysis
HyperCKemia and rhabdomyolysis in the neuroleptic malignant and serotonin syndromes: A literature review.
[object Object], [object Object], [object Object] et al. · Neuromuscul Disord · 2020
PMID: 33250373Meta-Analysis
Serotonin syndrome: a clinical review of current controversies.
[object Object], [object Object], [object Object] et al. · J Integr Neurosci · 2020
PMID: 33378846Meta-Analysis
Conundrums in neurology: diagnosing serotonin syndrome - a meta-analysis of cases.
[object Object], [object Object], [object Object] et al. · BMC Neurol · 2016
Animal models of the serotonin syndrome: a systematic review.
[object Object], [object Object], [object Object] et al. · Behav Brain Res · 2013
PMID: 24004848Meta-Analysis
Search all PubMed articles for Serotonin syndrome
Research data from MEDLINE/PubMed
Signs & Symptoms
Based on Human Phenotype Ontology (HPO) disease-phenotype annotations.
Abnormality of the autonomic nervous system
Very frequent (80-99%)HP:0002270
Confusion
Frequent (30-79%)HP:0001289
Diarrhea
Frequent (30-79%)HP:0002014
Elevated heart rate
Frequent (30-79%)HP:0001649
Excessive, persistent worry and fear
Frequent (30-79%)HP:0000739
Fragmented sleep
Frequent (30-79%)HP:0100785
Intellectual deterioration
Frequent (30-79%)HP:0001268
Involuntary jerking movements
Frequent (30-79%)HP:0001336
Irritable mood
Frequent (30-79%)HP:0000737
Nausea
Frequent (30-79%)HP:0002018
Restlessness
Frequent (30-79%)HP:0000711
Tremor
Frequent (30-79%)HP:0001337
Agitation
Occasional (5-29%)HP:0000713
Clonus
Occasional (5-29%)HP:0002169
Decreased alertness
Occasional (5-29%)HP:0032044
Dilated pupil
Occasional (5-29%)HP:0011499
High blood pressure
Occasional (5-29%)HP:0000822
Impaired saccades
Occasional (5-29%)HP:0000570
Increased reflexes
Occasional (5-29%)HP:0001347
Lacticacidosis
Occasional (5-29%)HP:0003128
Seizures
Occasional (5-29%)HP:0001250
Sweating
Occasional (5-29%)HP:0000975
Tachypnea
Occasional (5-29%)HP:0002789
Acute kidney failure
Very rare (1-4%)HP:0001919
Altered consciousness or cognition
Very rare (1-4%)HP:0031258
Breakdown of skeletal muscle
Very rare (1-4%)HP:0003201
Disseminated intravascular coagulation
Very rare (1-4%)HP:0005521
Hallucinations
Very rare (1-4%)HP:0000738
Hepatic insufficiency
Very rare (1-4%)HP:0001399
Hypertonia
Very rare (1-4%)HP:0001276
Related Conditions
Quick Facts
- SNOMED CT
- 371089000
- UMLS CUI
- C0699828
- Fully Specified Name
- Serotonin syndrome (disorder)
- Specialists
- 0
- Diagnostic Biomarkers
- 0
- HPO Phenotypes
- 30
Medical Disclaimer
This information is for educational purposes only and does not constitute medical advice, diagnosis, or treatment. Always consult with a qualified healthcare provider regarding any medical condition or treatment plan.
Clinical content is derived from the SNOMED CT clinical ontology and curated medical knowledge graphs.