Overview
Severe combined immunodeficiency disease is a disorder. There are currently 2 actively recruiting clinical trials.
Auto-generated from clinical reference data. Not a substitute for medical advice.
Treatments & Interventions
Clinical Trials
2
Total Trials
2
Recruiting
0
With Results
Recent Trials
Hematopoietic Stem Cell Transplantation (HSCT) for Common Variable Immunodeficiency (CVID) and Other Autoimmune Manifestations of Primary Immune Regulatory Disorders (PIRD)
NCT07284641Phase 2Recruiting25 enrolled
Immune Disorder HSCT Protocol
NCT01821781Phase 2Active Not Recruiting20 enrolled
Research Evidence
Peer-reviewed studies linked via MeSH term "Combined Immunodeficiencies, Severe" from the MEDLINE/PubMed database.
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Incidence, risk factors and outcomes of BCGosis following BCG vaccination in infants: a systematic review and meta-analyses.
[object Object], [object Object], [object Object] et al. · Front Immunol · 2025
[Current research on severe combined immunodeficiency with transplacental maternal engraftmentt].
[object Object], [object Object], [object Object] et al. · Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi · 2025
PMID: 40962442Meta-Analysis
Recommendations for uniform definitions used in newborn screening for severe combined immunodeficiency.
[object Object], [object Object], [object Object] et al. · J Allergy Clin Immunol · 2022
Clinical, Immunological, and Genetic Features in 49 Patients With ZAP-70 Deficiency: A Systematic Review.
[object Object], [object Object], [object Object] et al. · Front Immunol · 2020
Meta-analysis of hematopoietic stem cell transplantation in major histocompatibility complex class II deficiency.
[object Object], [object Object], [object Object] et al. · Pediatr Transplant · 2020
PMID: 32678504Meta-Analysis
TREC Based Newborn Screening for Severe Combined Immunodeficiency Disease: A Systematic Review.
[object Object], [object Object], [object Object] et al. · J Clin Immunol · 2015
Gene therapy as a new treatment option for inherited monogenic diseases.
[object Object] · Eur J Intern Med · 2014
PMID: 24129166Meta-Analysis
Systematic evidence review of newborn screening and treatment of severe combined immunodeficiency.
[object Object], [object Object], [object Object] et al. · Pediatrics · 2010
PMID: 20403930Meta-Analysis
Identification of severe combined immunodeficiency by T-cell receptor excision circles quantification using neonatal guthrie cards.
[object Object], [object Object], [object Object] et al. · J Pediatr · 2009
PMID: 19628217RCT
Advances and applications of genome-edited animal models for severe combined immunodeficiency.
[object Object], [object Object], [object Object] et al. · Zool Res · 2025
Search all PubMed articles for Severe combined immunodeficiency disease
Research data from MEDLINE/PubMed
Related Conditions
Severe combined immunodeficiency with maternofetal engraftment(child)
WHIM - Warts, hypogammaglobulinaemia, infections and myelokathexis(child)
SCID due to absent IL-2 receptor(child)
Swiss type agammaglobulinemia(child)
Combined immunodeficiency associated with maturation pathway defect(child)
Severe combined immunodeficiency due to absent adenosine deaminase(child)
Severe combined immunodeficiency due to absent interleukin-2 production(child)
Severe combined immunodeficiency due to absent T cell receptor(child)
Nezelof's syndrome(child)
Severe combined immunodeficiency with low T- and B-cell numbers(child)
Severe combined immunodeficiency with low or normal B-cell numbers(child)
Autosomal recessive severe combined immunodeficiency disease(child)
Severe combined immunodeficiency due to deoxyribonucleic acid dependent protein kinase catalytic subunit deficiency(child)
Anhidrotic ectodermal dysplasia, immunodeficiency, osteopetrosis, lymphedema syndrome(child)
T-B+ SCID - T-cell negative B-cell positive severe combined immunodeficiency(child)
Congenital immunodeficiency disease(parent)
Hereditary disorder of immune system(parent)
Combined immunodeficiency disease(parent)
Quick Facts
- SNOMED CT
- 31323000
- UMLS CUI
- C0085110
- Fully Specified Name
- Severe combined immunodeficiency disease (disorder)
- Specialists
- 0
- Diagnostic Biomarkers
- 0
- Known Treatments
- 1
- Clinical Trials
- 2
Medical Disclaimer
This information is for educational purposes only and does not constitute medical advice, diagnosis, or treatment. Always consult with a qualified healthcare provider regarding any medical condition or treatment plan.
Clinical content is derived from the SNOMED CT clinical ontology and curated medical knowledge graphs.