Substance / Medication

Acetazolamide

Overview

Active Ingredient
acetazolamide
RxNorm CUI
167

Indications

For adjunctive treatment of: edema due to congestive heart failure; drug-induced edema; centrencephalic epilepsies (petit mal, unlocalized seizures); chronic simple (open-angle) glaucoma, secondary glaucoma, and preoperatively in acute angle-closure glaucoma where delay of surgery is desired in order to lower intraocular pressure. Acetazolamide Tablets are also indicated for the prevention or amelioration of symptoms associated with acute mountain sickness in climbers attempting rapid ascent and

Labeler: AvKAREUpdated: 2026-02-24T00:00:00.000ZFull label on DailyMed

Contraindications

When this intervention should not be used

Acetazolamide therapy is contraindicated in situations in which sodium and/or potassium blood serum levels are depressed, in cases of marked kidney and liver disease or dysfunction, in suprarenal gland failure, and in hyperchloremic acidosis. It is contraindicated in patients with cirrhosis because

Indications & Related Conditions

Conditions associated via SNOMED clinical relationships

Administration & Protocol

Dosing, route, and treatment protocol

Detailed dosage and administration information is available in the full FDA drug label.

View full prescribing information on DailyMed

Monitoring & Follow-Up

Biomarkers relevant to this intervention via related conditions

Clinical Trials

160 trials linked to this intervention

160
Total Trials
13
Recruiting
57
With Results

Research Evidence

Published studies and systematic reviews

Sort:
Effectiveness of Topiramate Versus Acetazolamide in the Management of Idiopathic Intracranial Hypertension: ASystematic Review and Meta-Analysis.
Almaqhawi Abdullah, Alokley Alia, Alamri Reham et al. · Medicina (Kaunas) · 2025
PMID: 40142261Meta-AnalysisFull text (PMC)
Use of Acetazolamide in People with Decompensated Heart Failure: A Systematic Review and Meta-Analysis.
Erazo-Castillo Johana Elizabeth, Ramos-Picón Juan Camilo, Galván-Barrios Johana Patricia et al. · Curr Cardiol Rep · 2025
PMID: 40549243Meta-Analysis
Acetazolamide as an Adjunctive Diuretic Therapy for Patients with Acute Decompensated Heart Failure: A Systematic Review and Meta-Analysis.
Siddiqi Ahmed Kamal, Maniya Muhammad Talha, Alam Muhammad Tanveer et al. · Am J Cardiovasc Drugs · 2024
PMID: 38416359Meta-Analysis
Acetazolamide therapy in patients with acute heart failure: a systematic review and meta-analysis of randomized controlled trials.
Milbradt Tanize Louize, Sudo Renan Yuji Ura, Gobbo Marília Oberto da Silva et al. · Heart Fail Rev · 2024
PMID: 38985385Meta-Analysis
Acetazolamide for acute kidney injury in patients undergoing high dose methotrexate therapy: a systematic review and meta-analysis.
Truong Hong Hieu, Reddy Swetha, Charkviani Mariam et al. · J Nephrol · 2024
PMID: 38265601Meta-Analysis
Treatment Effects of Acetazolamide on Ischemic Stroke: A Meta-Analysis and Systematic Review.
Liu Meng, Li Heng, Fan Lijun et al. · World Neurosurg · 2024
PMID: 38423457Meta-Analysis
The role of acetazolamide in sleep apnea at sea level: a systematic review and meta-analysis.
Ni Yue-Nan, Yang Huan, Thomas Robert Joseph · J Clin Sleep Med · 2021
PMID: 33538687Meta-AnalysisFull text (PMC)

Research data from MEDLINE/PubMed

Benefits & Expected Outcomes

Benefits, expected outcomes, efficacy data, and NNT (Number Needed to Treat) are pending physician authorship and evidence review.

Risks & Side Effects

Adverse reaction and safety data for this drug is sourced from the FDA-approved label.

View adverse reactions & drug interactions on DailyMed

Related Symptoms

Symptoms associated with conditions this intervention addresses

No related symptoms have been mapped yet. Symptom linkages are derived through associated conditions.

Alternatives & Comparisons

Alternative treatments, comparison data, and clinical decision support are pending physician authorship.

Medical Disclaimer

This information is for educational purposes only and does not constitute medical advice, diagnosis, or treatment. Always consult with a qualified healthcare provider regarding any medical condition or treatment plan.

Do not start, stop, or change any treatment without consulting your healthcare provider.

Specialists

Providers who commonly manage this intervention

Health Goals

Goals connected through associated conditions

Quick Facts

Type
Substance / Medication
Fully Specified Name
Acetazolamide (substance)
SNOMED CT
372709008
UMLS CUI
C0000981
RxNorm CUI
167
Labeler
AvKARE

Clinical Data

This intervention maps to 5 entities in the Healos knowledge graph.

2
Conditions
1
Biomarkers
1
Specialists
0
Symptoms
160
Clinical Trials

Data is sourced from SNOMED CT, UMLS, and the Healos clinical knowledge graph. Content sections marked as pending require physician authorship. Consult a healthcare provider before starting any treatment.