Substance / Medication

Adrenaline

Overview

Active Ingredient
epinephrine
RxNorm CUI
3992

Indications

Epinephrine injection is indicated in the emergency treatment of allergic reactions (Type I) including anaphylaxis to stinging insects (e.g., order Hymenoptera, which includes bees, wasps, hornets, yellow jackets and fire ants), and biting insects (e.g., triatoma, mosquitoes), allergen immunotherapy, foods, drugs, diagnostic testing substances (e.g., radiocontrast media), and other allergens, as well as idiopathic anaphylaxis or exercise-induced anaphylaxis. Epinephrine injection is intended for

Labeler: REMEDYREPACK INC.Updated: 2026-02-18T00:00:00.000ZFull label on DailyMed

Contraindications

When this intervention should not be used

None.

Indications & Related Conditions

Conditions associated via SNOMED clinical relationships

Administration & Protocol

Dosing, route, and treatment protocol

Detailed dosage and administration information is available in the full FDA drug label.

View full prescribing information on DailyMed

Monitoring & Follow-Up

Biomarkers relevant to this intervention via related conditions

No monitoring biomarkers have been mapped yet. Biomarker-intervention linkages are derived through related conditions and will expand as the knowledge graph grows.

Clinical Trials

23 trials linked to this intervention

23
Total Trials
5
Recruiting
6
With Results

Research Evidence

Published studies and systematic reviews

Sort:
Association of noradrenaline dose with mortality in critically ill patients: a systematic review and dose-response meta-analysis.
Reinikainen Matti, Delamarre Louis, Blaser Annika Reintam et al. · Crit Care · 2025
PMID: 41267052Meta-AnalysisFull text (PMC)
Epinephrine (adrenaline) compared to selective beta-2-agonist in adults or children with acute asthma: a systematic review and meta-analysis.
Baggott Christina, Hardy Jo Katherine, Sparks Jenny et al. · Thorax · 2022
PMID: 34593615Meta-Analysis
Systematic review and meta-analysis appraising efficacy and safety of adrenaline for adult cardiopulmonary resuscitation.
Ludwin Kobi, Safiejko Kamil, Smereka Jacek et al. · Cardiol J · 2021
PMID: 33140398Meta-AnalysisFull text (PMC)
Efficacy and adverse events of selective serotonin noradrenaline reuptake inhibitors in the management of postoperative pain: A systematic review and meta-analysis.
Schnabel Alexander, Weibel Stephanie, Reichl Sylvia U et al. · J Clin Anesth · 2021
PMID: 34311244Meta-Analysis
Early Administration of Adrenaline for Out-of-Hospital Cardiac Arrest: A Systematic Review and Meta-Analysis.
Ran Liyu, Liu Jinglun, Tanaka Hideharu et al. · J Am Heart Assoc · 2020
PMID: 32441184Meta-AnalysisFull text (PMC)
Adrenaline Auto-injector injuries to digits; a systematic review and recommendations for emergency management.
Walsh Karl, Baker Benjamin G, Iyer Srinivasan · Surgeon · 2020
PMID: 32044290Meta-Analysis

Research data from MEDLINE/PubMed

Benefits & Expected Outcomes

Benefits, expected outcomes, efficacy data, and NNT (Number Needed to Treat) are pending physician authorship and evidence review.

Risks & Side Effects

Adverse reaction and safety data for this drug is sourced from the FDA-approved label.

View adverse reactions & drug interactions on DailyMed

Related Symptoms

Symptoms associated with conditions this intervention addresses

No related symptoms have been mapped yet. Symptom linkages are derived through associated conditions.

Alternatives & Comparisons

Alternative treatments, comparison data, and clinical decision support are pending physician authorship.

Medical Disclaimer

This information is for educational purposes only and does not constitute medical advice, diagnosis, or treatment. Always consult with a qualified healthcare provider regarding any medical condition or treatment plan.

Do not start, stop, or change any treatment without consulting your healthcare provider.

Quick Facts

Type
Substance / Medication
Fully Specified Name
Epinephrine (substance)
SNOMED CT
387362001
UMLS CUI
C0014563
RxNorm CUI
3992
Labeler
REMEDYREPACK INC.

Clinical Data

This intervention maps to 11 entities in the Healos knowledge graph.

11
Conditions
0
Biomarkers
0
Specialists
0
Symptoms
23
Clinical Trials

Data is sourced from SNOMED CT, UMLS, and the Healos clinical knowledge graph. Content sections marked as pending require physician authorship. Consult a healthcare provider before starting any treatment.