Substance / Medication

Aztreonam

Overview

Active Ingredient
aztreonam
RxNorm CUI
1272

Indications

To reduce the development of drug-resistant bacteria and maintain the effectiveness of AZACTAM (aztreonam for injection, USP) and other antibacterial drugs, AZACTAM should be used only to treat or prevent infections that are proven or strongly suspected to be caused by susceptible bacteria. When culture and susceptibility information are available, they should be considered in selecting or modifying antibacterial therapy. In the absence of such data, local epidemiology and susceptibility pattern

Labeler: E.R. Squibb & Sons, L.L.C.Updated: 2025-12-15T00:00:00.000ZFull label on DailyMed

Contraindications

When this intervention should not be used

This preparation is contraindicated in patients with known hypersensitivity to aztreonam or any other component in the formulation.

Indications & Related Conditions

Conditions associated via SNOMED clinical relationships

Administration & Protocol

Dosing, route, and treatment protocol

Detailed dosage and administration information is available in the full FDA drug label.

View full prescribing information on DailyMed

Monitoring & Follow-Up

Biomarkers relevant to this intervention via related conditions

No monitoring biomarkers have been mapped yet. Biomarker-intervention linkages are derived through related conditions and will expand as the knowledge graph grows.

Clinical Trials

3 trials linked to this intervention

3
Total Trials
1
Recruiting
1
With Results

Research Evidence

Published studies and systematic reviews

Sort:
Safety and Tolerability of Inhaled Aztreonam in Children and Adolescents: A Systematic Review and Meta-Analysis.
Rastely-Junior Valmir N, Rocha Hosanea S N, Reis Mitermayer G · Adv Respir Med · 2025
PMID: 41149131Meta-AnalysisFull text (PMC)
Aztreonam for Neisseria gonorrhoeae: a systematic review and meta-analysis.
Barbee Lindley A, Golden Matthew R · J Antimicrob Chemother · 2020
PMID: 32259846Meta-AnalysisFull text (PMC)
Inhaled antibiotics beyond aminoglycosides, polymyxins and aztreonam: A systematic review.
Falagas Matthew E, Trigkidis Kyriakos K, Vardakas Konstantinos Z · Int J Antimicrob Agents · 2015
PMID: 25533880Meta-Analysis
ALPINE2: Efficacy and safety of 14-day vs 28-day inhaled aztreonam for Pa eradication in children with cystic fibrosis.
Gilchrist Francis J, Bui Stephanie, Gartner Silvia et al. · J Cyst Fibros · 2024
PMID: 37455237RCT
An 18-month study of the safety and efficacy of repeated courses of inhaled aztreonam lysine in cystic fibrosis.
Oermann Christopher M, Retsch-Bogart George Z, Quittner Alexandra L et al. · Pediatr Pulmonol · 2010
PMID: 20672296RCTFull text (PMC)
Microbiology, safety, and pharmacokinetics of aztreonam lysinate for inhalation in patients with cystic fibrosis.
Gibson Ronald L, Retsch-Bogart George Z, Oermann Christopher et al. · Pediatr Pulmonol · 2006
PMID: 16703579RCT
Inhaled aztreonam lysine in the management ofin patients with cystic fibrosis: real-life effectiveness.
Jiménez-Lozano Inés, Luna-Paredes Carmen, Monte-Boquet Emilio et al. · Eur J Hosp Pharm · 2025
PMID: 38071521Observational

Research data from MEDLINE/PubMed

Benefits & Expected Outcomes

Benefits, expected outcomes, efficacy data, and NNT (Number Needed to Treat) are pending physician authorship and evidence review.

Risks & Side Effects

Adverse reaction and safety data for this drug is sourced from the FDA-approved label.

View adverse reactions & drug interactions on DailyMed

Related Symptoms

Symptoms associated with conditions this intervention addresses

No related symptoms have been mapped yet. Symptom linkages are derived through associated conditions.

Alternatives & Comparisons

Alternative treatments, comparison data, and clinical decision support are pending physician authorship.

Medical Disclaimer

This information is for educational purposes only and does not constitute medical advice, diagnosis, or treatment. Always consult with a qualified healthcare provider regarding any medical condition or treatment plan.

Do not start, stop, or change any treatment without consulting your healthcare provider.

Quick Facts

Type
Substance / Medication
Fully Specified Name
Aztreonam (substance)
SNOMED CT
387386004
UMLS CUI
C0004521
RxNorm CUI
1272
Labeler
E.R. Squibb & Sons, L.L.C.

Clinical Data

This intervention maps to 8 entities in the Healos knowledge graph.

8
Conditions
0
Biomarkers
0
Specialists
0
Symptoms
3
Clinical Trials

Data is sourced from SNOMED CT, UMLS, and the Healos clinical knowledge graph. Content sections marked as pending require physician authorship. Consult a healthcare provider before starting any treatment.