Substance / Medication

Capecitabine

Overview

Active Ingredient
capecitabine
RxNorm CUI
194000
Labeler: H2-Pharma, LLCUpdated: 2026-02-05T00:00:00.000ZFull label on DailyMed

Boxed Warning

FDA Black Box Warning

Increased risk of serious adverse reactions or death in patients with complete DPD deficiency DPYD DPYD Warnings and Precautions (5.1) • Test patients for genetic variants ofprior to initiating XELODA unless immediate treatment is necessary. Avoid use of XELODA in patients with certain homozygous or

Contraindications

When this intervention should not be used

Adverse Reactions (6.1) [see] XELODA is contraindicated in patients with history of severe hypersensitivity reaction to fluorouracil or capecitabine.

Indications & Related Conditions

Conditions associated via SNOMED clinical relationships

Administration & Protocol

Dosing, route, and treatment protocol

Detailed dosage and administration information is available in the full FDA drug label.

View full prescribing information on DailyMed

Monitoring & Follow-Up

Biomarkers relevant to this intervention via related conditions

No monitoring biomarkers have been mapped yet. Biomarker-intervention linkages are derived through related conditions and will expand as the knowledge graph grows.

Research Evidence

Published studies and systematic reviews

Sort:
Efficacy and Safety of Metronomic Capecitabine in Hepatocellular Carcinoma: A Systematic Review and Meta-analysis.
Gupta Nandini, Verma Neelkant, Patel Bhoomika · J Gastrointest Cancer · 2024
PMID: 39160369Meta-Analysis
Capecitabine-based chemotherapy in early-stage triple-negative breast cancer: a meta-analysis.
Bai Jie, Yao Xufeng, Pu Yinghong et al. · Front Oncol · 2023
PMID: 37954087Meta-AnalysisFull text (PMC)
Meta-analysis of three randomized trials of capecitabine plus cisplatin (XP) versus S-1 plus cisplatin (SP) as first-line treatment for advanced gastric cancer.
Nishikawa Kazuhiro, Kawakami Hisato, Shimokawa Toshio et al. · Int J Clin Oncol · 2023
PMID: 37634209Meta-Analysis
Traditional Chinese medicines and capecitabine-based chemotherapy for colorectal cancer treatment: A meta-analysis.
Jiang Hui-Zhong, Jiang Ya-Li, Yang Bing et al. · Cancer Med · 2023
PMID: 35650714Meta-AnalysisFull text (PMC)
Role and efficacy of capecitabine in the anthracycline-free regimen in breast cancer patients: a systematic review and meta-analysis.
Wang Sisi, Deng Lufeng, Chen Jiaren et al. · J Cancer Res Clin Oncol · 2023
PMID: 37891407Meta-AnalysisFull text (PMC)

Research data from MEDLINE/PubMed

Benefits & Expected Outcomes

Benefits, expected outcomes, efficacy data, and NNT (Number Needed to Treat) are pending physician authorship and evidence review.

Risks & Side Effects

Adverse reaction and safety data for this drug is sourced from the FDA-approved label.

View adverse reactions & drug interactions on DailyMed

Related Symptoms

Symptoms associated with conditions this intervention addresses

No related symptoms have been mapped yet. Symptom linkages are derived through associated conditions.

Alternatives & Comparisons

Alternative treatments, comparison data, and clinical decision support are pending physician authorship.

Medical Disclaimer

This information is for educational purposes only and does not constitute medical advice, diagnosis, or treatment. Always consult with a qualified healthcare provider regarding any medical condition or treatment plan.

Do not start, stop, or change any treatment without consulting your healthcare provider.

Quick Facts

Type
Substance / Medication
Fully Specified Name
Capecitabine (substance)
SNOMED CT
386906001
UMLS CUI
C0671970
RxNorm CUI
194000
Labeler
H2-Pharma, LLC

Clinical Data

This intervention maps to 2 entities in the Healos knowledge graph.

2
Conditions
0
Biomarkers
0
Specialists
0
Symptoms

Data is sourced from SNOMED CT, UMLS, and the Healos clinical knowledge graph. Content sections marked as pending require physician authorship. Consult a healthcare provider before starting any treatment.