Substance / Medication

Carbidopa

Overview

Active Ingredient
carbidopa
RxNorm CUI
2019

Indications

6 Carbidopa and levodopa tablets are indicated in the treatment of the symptoms of idiopathic Parkinson's disease (paralysis agitans), post-encephalitic parkinsonism, and symptomatic parkinsonism which may follow injury to the nervous system by carbon monoxide intoxication and/or manganese intoxication. This product is indicated in these conditions to permit the administration of lower doses of levodopa with reduced nausea and vomiting, with more rapid dosage titration, with a somewhat smoother

Labeler: Aphena Pharma Solutions - Tennessee, Inc.Updated: 2012-07-17T00:00:00.000ZFull label on DailyMed

Contraindications

When this intervention should not be used

PRECAUTIONS, Drug Interactions Nonselective monoamine oxidase (MAO) inhibitors are contraindicated for use with carbidopa and levodopa. These inhibitors must be discontinued at least two weeks prior to initiating therapy with this combination product. Carbidopa and levodopa may be administered conco

Indications & Related Conditions

Conditions associated via SNOMED clinical relationships

Administration & Protocol

Dosing, route, and treatment protocol

Detailed dosage and administration information is available in the full FDA drug label.

View full prescribing information on DailyMed

Monitoring & Follow-Up

Biomarkers relevant to this intervention via related conditions

No monitoring biomarkers have been mapped yet. Biomarker-intervention linkages are derived through related conditions and will expand as the knowledge graph grows.

Research Evidence

Published studies and systematic reviews

Sort:
Effects of levodopa/carbidopa intestinal gel infusion on autonomic symptoms in advanced Parkinson's disease: a systematic review.
Galli Silvia, De Carolis Lanfranco, Bianchini Edoardo et al. · Clin Auton Res · 2025
PMID: 39633032Meta-AnalysisFull text (PMC)
Acute/subacutae demyelinating polyneuropathy in Parkinson's Disease patients on levodopa-carbidopa intestinal gel therapy: systematic review with new case report.
Piekarski Radosław, Roszmann Anna, Dulski Jarosław et al. · Neurol Neurochir Pol · 2023
PMID: 36628506Meta-Analysis
Intrajejunal Infusion of Levodopa/Carbidopa for Advanced Parkinson's Disease: A Systematic Review.
Tsunemi Taiji, Oyama Genko, Saiki Shinji et al. · Mov Disord · 2021
PMID: 33899262Meta-AnalysisFull text (PMC)
Impact of carbidopa-levodopa enteral suspension on quality of life and activities of daily living in patients with advanced Parkinson's disease: Results from a pooled meta-analysis.
Standaert David G, Patel Vardhaman, Snedecor Sonya J et al. · Parkinsonism Relat Disord · 2021
PMID: 33857722Meta-Analysis
The Advantages of Levodopa-Carbidopa Intestinal Gel for Patients with Advanced Parkinson's Disease: A Systematic Review.
Zhang Xing-Ru, Jiang Zhi-Yu, Zhang Zeng-Rui et al. · Drug Des Devel Ther · 2020
PMID: 32161444Meta-AnalysisFull text (PMC)
Levodopa/carbidopa/entacapone for the treatment of early Parkinson's disease: a meta-analysis.
Liao Xiaoli, Wu Nianyue, Liu Dongfeng et al. · Neurol Sci · 2020
PMID: 32162166Meta-Analysis

Research data from MEDLINE/PubMed

Benefits & Expected Outcomes

Benefits, expected outcomes, efficacy data, and NNT (Number Needed to Treat) are pending physician authorship and evidence review.

Risks & Side Effects

Adverse reaction and safety data for this drug is sourced from the FDA-approved label.

View adverse reactions & drug interactions on DailyMed

Related Symptoms

Symptoms associated with conditions this intervention addresses

No related symptoms have been mapped yet. Symptom linkages are derived through associated conditions.

Alternatives & Comparisons

Alternative treatments, comparison data, and clinical decision support are pending physician authorship.

Medical Disclaimer

This information is for educational purposes only and does not constitute medical advice, diagnosis, or treatment. Always consult with a qualified healthcare provider regarding any medical condition or treatment plan.

Do not start, stop, or change any treatment without consulting your healthcare provider.

Quick Facts

Type
Substance / Medication
Fully Specified Name
Carbidopa (substance)
SNOMED CT
73579000
UMLS CUI
C0006982
RxNorm CUI
2019
Labeler
Aphena Pharma Solutions - Tennessee, Inc.

Clinical Data

This intervention maps to 1 entities in the Healos knowledge graph.

1
Conditions
0
Biomarkers
0
Specialists
0
Symptoms

Data is sourced from SNOMED CT, UMLS, and the Healos clinical knowledge graph. Content sections marked as pending require physician authorship. Consult a healthcare provider before starting any treatment.