Substance / Medication

Cefotetan

Overview

Active Ingredient
cefotetan
RxNorm CUI
2187

Indications

To reduce the development of drug-resistant bacteria and maintain the effectiveness of cefotetan and other antibacterial drugs, cefotetan should be used only to treat or prevent infections that are proven or strongly suspected to be caused by susceptible bacteria. When culture and susceptibility information are available, they should be considered in selecting or modifying antibacterial therapy. In the absence of such data, local epidemiology and susceptibility patterns may contribute to the emp

Labeler: Hikma Pharmaceuticals USA Inc.Updated: 2024-04-11T00:00:00.000ZFull label on DailyMed

Contraindications

When this intervention should not be used

Cefotetan is contraindicated in patients with a known allergy to the cephalosporin group of antibiotics and in those individuals who have experienced a cephalosporin associated hemolytic anemia.

Indications & Related Conditions

Conditions associated via SNOMED clinical relationships

Administration & Protocol

Dosing, route, and treatment protocol

Detailed dosage and administration information is available in the full FDA drug label.

View full prescribing information on DailyMed

Monitoring & Follow-Up

Biomarkers relevant to this intervention via related conditions

No monitoring biomarkers have been mapped yet. Biomarker-intervention linkages are derived through related conditions and will expand as the knowledge graph grows.

Clinical Trials

121 trials linked to this intervention

121
Total Trials
30
Recruiting
15
With Results

Research Evidence

Published studies and systematic reviews

Sort:
Pharmacokinetic differences between the epimers of cefotetan disodium after single intravenous injection in healthy Chinese volunteers.
Su Meng-xiang, Liu Min-hong, Di Bin et al. · Eur J Drug Metab Pharmacokinet · 2011
PMID: 21915733RCT
Infection after elective colorectal surgery: bacteriological analysis of failures in a randomized trial of cefotetan vs. ertapenem prophylaxis.
Goldstein Ellie J C, Citron Diane M, Merriam C Vreni et al. · Surg Infect (Larchmt) · 2009
PMID: 19226203RCT
Comparative costs of ertapenem and cefotetan as prophylaxis for elective colorectal surgery.
Wilson Samuel E, Turpin Robin S, Kumar Ritesh N et al. · Surg Infect (Larchmt) · 2008
PMID: 18570576Observational
Effect of body mass index and ertapenem versus cefotetan prophylaxis on surgical site infection in elective colorectal surgery.
Itani Kamal M F, Jensen Erin H, Finn Tyler S et al. · Surg Infect (Larchmt) · 2008
PMID: 18426345Observational
Ertapenem versus cefotetan prophylaxis in elective colorectal surgery.
Itani Kamal M F, Wilson Samuel E, Awad Samir S et al. · N Engl J Med · 2006
PMID: 17182989Observational
A Repeat Case of Cefotetan-Induced Hemolytic Anemia in a Surgical Patient.
Gallagher Alayna, Roberts David, Kwok Raymond et al. · Cureus · 2022
PMID: 36439576Case ReportFull text (PMC)
Cefotetan-Induced Hemolytic Anemia: Case Series and Review.
Lim Kathlyn, Tran Hai, Hirai-Yang Angela et al. · J Pharm Pract · 2019
PMID: 30189781Case Report
Fatal drug-induced immune hemolytic anemia due to cefotetan; A case study.
Perkins Jim · Asian J Transfus Sci · 2008
PMID: 20041074Case ReportFull text (PMC)

Research data from MEDLINE/PubMed

Benefits & Expected Outcomes

Benefits, expected outcomes, efficacy data, and NNT (Number Needed to Treat) are pending physician authorship and evidence review.

Risks & Side Effects

Adverse reaction and safety data for this drug is sourced from the FDA-approved label.

View adverse reactions & drug interactions on DailyMed

Related Symptoms

Symptoms associated with conditions this intervention addresses

No related symptoms have been mapped yet. Symptom linkages are derived through associated conditions.

Alternatives & Comparisons

Alternative treatments, comparison data, and clinical decision support are pending physician authorship.

Medical Disclaimer

This information is for educational purposes only and does not constitute medical advice, diagnosis, or treatment. Always consult with a qualified healthcare provider regarding any medical condition or treatment plan.

Do not start, stop, or change any treatment without consulting your healthcare provider.

Quick Facts

Type
Substance / Medication
Fully Specified Name
Cefotetan (substance)
SNOMED CT
13585009
UMLS CUI
C0007555
RxNorm CUI
2187
Labeler
Hikma Pharmaceuticals USA Inc.

Clinical Data

This intervention maps to 19 entities in the Healos knowledge graph.

19
Conditions
0
Biomarkers
0
Specialists
0
Symptoms
121
Clinical Trials

Data is sourced from SNOMED CT, UMLS, and the Healos clinical knowledge graph. Content sections marked as pending require physician authorship. Consult a healthcare provider before starting any treatment.