Substance / Medication

Cevimeline

SNOMED 409284005 UMLS C0093437

Overview

Active Ingredient

cevimeline

RxNorm CUI

44281

Indications & Related Conditions

Conditions associated via SNOMED clinical relationships

Hyposecretion of salivary gland

Administration & Protocol

Dosing, route, and treatment protocol

Administration details including route, dosing schedules, preparation instructions, and contraindications are pending physician authorship.

Monitoring & Follow-Up

Biomarkers relevant to this intervention via related conditions

No monitoring biomarkers have been mapped yet. Biomarker-intervention linkages are derived through related conditions and will expand as the knowledge graph grows.

Clinical Trials

1 trials linked to this intervention

Total Trials

Recruiting

With Results

Recent Trials

Study of the Effectiveness of Cevimeline on Oral Health in Patients With Radiation Induced Xerostomia

NCT00466388Phase 4Completed54 enrolled

View all 1 trials on ClinicalTrials.gov

Research Evidence

Published studies and systematic reviews

Sort:

Is Acupuncture an Effective Treatment for Radiation-Induced Xerostomia of Patients with Head and Neck Cancer? A Systematic Review and Meta-Analysis.

Gu Wenzhe, Dong Hongjun, Yuan Yuan et al. · J Integr Complement Med · 2025

PMID: 39600262Meta-Analysis

Predictive biomarkers of radiotherapy- related dermatitis, xerostomia, mucositis and dysphagia in head and neck cancer: A systematic review.

Koch Alexander, Reinhardt Philipp, Elicin Olgun et al. · Radiother Oncol · 2025

PMID: 39706342Meta-Analysis

[A study of the sialogogic effect of cevimeline gargle].

Yoshikawa Chizuko, Takamatsu Yasushi, Ogata Kentaro et al. · Gan To Kagaku Ryoho · 2013

PMID: 23411958RCT

The efficacy of cevimeline hydrochloride in the treatment of xerostomia in Sjögren's syndrome in southern Chinese patients: a randomised double-blind, placebo-controlled crossover study.

Leung K C M, McMillan A S, Wong M C M et al. · Clin Rheumatol · 2008

PMID: 17899308RCT

Parotid irrigation and cevimeline gargle for treatment of xerostomia in Sjögren's syndrome.

Takagi Yukinori, Katayama Ikuo, Tashiro Shigeki et al. · J Rheumatol · 2008

PMID: 19004065Trial

Efficacy prediction of cevimeline in patients with Sjögren's syndrome.

Yamada Hiroyuki, Nakagawa Yoichi, Wakamatsu Ei et al. · Clin Rheumatol · 2007

PMID: 17221146Trial

Effect of cevimeline on salivary components in patients with Sjögren syndrome.

Suzuki Kimihiro, Matsumoto Mitsuyo, Nakashima Masahiro et al. · Pharmacology · 2005

PMID: 15722648Trial

Therapeutic effect of cevimeline on dry eye in patients with Sjögren's syndrome: a randomized, double-blind clinical study.

Ono Masasfumi, Takamura Etsuko, Shinozaki Kazumi et al. · Am J Ophthalmol · 2004

PMID: 15234277Trial

Cevimeline for the treatment of xerostomia in patients with Sjögren syndrome: a randomized trial.

Fife Rose S, Chase Walter F, Dore Robin K et al. · Arch Intern Med · 2002

PMID: 12038948Trial

A double-blind, randomized, placebo-controlled study of cevimeline in Sjögren's syndrome patients with xerostomia and keratoconjunctivitis sicca.

Petrone Dianne, Condemi John J, Fife Rose et al. · Arthritis Rheum · 2002

PMID: 11920411Trial

Research data from MEDLINE/PubMed

Benefits & Expected Outcomes

Benefits, expected outcomes, efficacy data, and NNT (Number Needed to Treat) are pending physician authorship and evidence review.

Risks & Side Effects

Risk profile, common and serious adverse effects, contraindications, and drug interactions are pending physician authorship.

Related Symptoms

Symptoms associated with conditions this intervention addresses

No related symptoms have been mapped yet. Symptom linkages are derived through associated conditions.

Alternatives & Comparisons

Alternative treatments, comparison data, and clinical decision support are pending physician authorship.

Medical Disclaimer

This information is for educational purposes only and does not constitute medical advice, diagnosis, or treatment. Always consult with a qualified healthcare provider regarding any medical condition or treatment plan.

Do not start, stop, or change any treatment without consulting your healthcare provider.

Quick Facts

Type: Substance / Medication
Fully Specified Name: Cevimeline (substance)
SNOMED CT: 409284005
UMLS CUI: C0093437
RxNorm CUI: 44281

Clinical Data

This intervention maps to 1 entities in the Ltrl knowledge graph.

Conditions

Biomarkers

Specialists

Symptoms

Clinical Trials

Data is sourced from SNOMED CT, UMLS, and the Ltrl clinical knowledge graph. Content sections marked as pending require physician authorship. Consult a healthcare provider before starting any treatment.