Back to Interventions
Substance / Medication

Chlorhexidine diacetate

SNOMED 96317008UMLS C0521947

Overview

Clinical overview including description, indications, and evidence base is pending physician authorship or FDA SPL integration. Graph-derived relationship data is available below.

Indications & Related Conditions

Conditions associated via SNOMED clinical relationships

Periodontal disease
Candidiasis of mouth
Infection of skin
Disease caused by Gram-negative bacteria

Administration & Protocol

Dosing, route, and treatment protocol

Administration details including route, dosing schedules, preparation instructions, and contraindications are pending physician authorship.

Monitoring & Follow-Up

Biomarkers relevant to this intervention via related conditions

No monitoring biomarkers have been mapped yet. Biomarker-intervention linkages are derived through related conditions and will expand as the knowledge graph grows.

Clinical Trials

3 trials linked to this intervention

3
Total Trials
0
Recruiting
0
With Results

Recent Trials

A Study to Compare the Use of Fluconazole as Continuous Therapy Versus Periodic Therapy in HIV-Positive Patients With Recurrent Thrush

NCT00000951Phase 4Completed948 enrolled

Fluconazole Prophylaxis of Thrush in AIDS

NCT00001542Phase 4Completed80 enrolled

Study to Assess the Incidence of Local Oropharyngeal and Laryngeal Adverse Effects of Advair DISKUS 250/50 mcg BID

NCT00235053Phase 4Completed13 enrolled
View all 3 trials on ClinicalTrials.gov

Research Evidence

Published studies and systematic reviews

Sort:
The long-term effect of a zinc acetate and chlorhexidine diacetate containing mouth rinse on intra-oral halitosis-A randomized clinical trial.
Erovic Ademovski Seida, Mårtensson Carina, Persson Gösta Rutger et al. · J Clin Periodontol · 2017
PMID: 28727160RCT
Retention and marginal leakage of provisional crowns cemented with provisional cements enriched with chlorhexidine diacetate.
Lewinstein Israel, Chweidan Harry, Matalon Shlomo et al. · J Prosthet Dent · 2007
PMID: 18021826RCT
Incorporation of chlorhexidine diacetate in provisional cements: antimicrobial activity against Streptococcus mutans and the effect on tensile strength in vitro.
Lewinstein I, Zenziper E, Block J et al. · Int Endod J · 2012
PMID: 22563792Observational
Antibacterial activity and physical properties of conventional glass-ionomer cements containing chlorhexidine diacetate/cetrimide mixtures.
Tüzüner Tamer, Kuşgöz Adem, Er Kürşat et al. · J Esthet Restor Dent · 2011
PMID: 21323839Observational
Controlled release of chlorhexidine diacetate from a porous methacrylate system: supercritical fluid assisted foaming and impregnation.
Gong K, Braden M, Patel M P et al. · J Pharm Sci · 2007
PMID: 17301965Observational
Antimicrobial potential and biological properties of modified glass-ionomer cement supplemented with chlorhexidine diacetate.
Jitpukdeebodintra Suwanna, Tannukit Sissada, Rotpenpian Nattapon · J Oral Sci · 2025
PMID: 40670122Other
The Antibacterial and Antifungal Activity of Chlorhexidine Diacetate Incorporated into Acrylic Resins Used in Provisional Restorations.
Ata Secil Ozkan, Akay Canan, Mumcu Emre et al. · Acta Stomatol Croat · 2023
PMID: 37808409OtherFull text (PMC)
Antimicrobial Efficacy of Glass Ionomer Cement in Incorporation with BiogenicCapped Silver-Nanobiotic, Chlorhexidine Diacetate and Lyophilized Miswak.
Ashour Amal Adnan, Basha Sakeenabi, Felemban Nayef H et al. · Molecules · 2022
PMID: 35056835OtherFull text (PMC)
Effectiveness of chlorhexidine diacetate and povidone-iodine in antiseptic preparation of the canine external ear canal prior to total ear canal ablation with bulla osteotomy procedure: A preliminary study.
Nye Alicia K, Rogovskyy Artem, Lazarus Matthew A et al. · Vet Med Sci · 2023
PMID: 37418348PreclinicalFull text (PMC)
Prevention of medical device infections via multi-action nitric oxide and chlorhexidine diacetate releasing medical grade silicone biointerfaces.
Chug Manjyot Kaur, Massoumi Hamed, Wu Yi et al. · J Biomed Mater Res A · 2022
PMID: 35170212PreclinicalFull text (PMC)

Research data from MEDLINE/PubMed

Benefits & Expected Outcomes

Benefits, expected outcomes, efficacy data, and NNT (Number Needed to Treat) are pending physician authorship and evidence review.

Risks & Side Effects

Risk profile, common and serious adverse effects, contraindications, and drug interactions are pending physician authorship.

Related Symptoms

Symptoms associated with conditions this intervention addresses

No related symptoms have been mapped yet. Symptom linkages are derived through associated conditions.

Alternatives & Comparisons

Alternative treatments, comparison data, and clinical decision support are pending physician authorship.

Medical Disclaimer

This information is for educational purposes only and does not constitute medical advice, diagnosis, or treatment. Always consult with a qualified healthcare provider regarding any medical condition or treatment plan.

Do not start, stop, or change any treatment without consulting your healthcare provider.

Quick Facts

Type
Substance / Medication
Fully Specified Name
Chlorhexidine diacetate (substance)
SNOMED CT
96317008
UMLS CUI
C0521947

Clinical Data

This intervention maps to 4 entities in the Healos knowledge graph.

4
Conditions
0
Biomarkers
0
Specialists
0
Symptoms
3
Clinical Trials

Data is sourced from SNOMED CT, UMLS, and the Healos clinical knowledge graph. Content sections marked as pending require physician authorship. Consult a healthcare provider before starting any treatment.