Substance / Medication

Cimetidine

Overview

Active Ingredient
cimetidine
RxNorm CUI
2541

Indications

Cimetidine tablets are indicated in: 1. Short-term treatment of active duodenal ulcer. DOSAGE AND ADMINISTRATION: Duodenal Ulcer Most patients heal within 4 weeks and there is rarely reason to use cimetidine tablets at full dosage for longer than 6 to 8 weeks (see). Concomitant antacids should be given as needed for relief of pain. However, simultaneous administration of cimetidine tablets and antacids is not recommended, since antacids have been reported to interfere with the absorption of cime

Labeler: Northwind Health Company, LLCUpdated: 2026-01-01T00:00:00.000ZFull label on DailyMed

Contraindications

When this intervention should not be used

Cimetidine tablets are contraindicated for patients known to have hypersensitivity to the product.

Indications & Related Conditions

Conditions associated via SNOMED clinical relationships

Administration & Protocol

Dosing, route, and treatment protocol

Detailed dosage and administration information is available in the full FDA drug label.

View full prescribing information on DailyMed

Monitoring & Follow-Up

Biomarkers relevant to this intervention via related conditions

No monitoring biomarkers have been mapped yet. Biomarker-intervention linkages are derived through related conditions and will expand as the knowledge graph grows.

Research Evidence

Published studies and systematic reviews

Sort:
Cimetidine repurposed as a potential immunomodulatory agent against colorectal carcinoma: A systematic review.
Gunasekara Wwm, Sachindra Jlaa, Madhushika M T et al. · J Oncol Pharm Pract · 2024
PMID: 38592456Meta-Analysis
Acute pancreatitis and the role of histamine-2 receptor antagonists: a meta-analysis of randomized controlled trials of cimetidine.
Morimoto Takeshi, Noguchi Yoshinori, Sakai Tatsuya et al. · Eur J Gastroenterol Hepatol · 2002
PMID: 12072603Meta-Analysis
Validation of a Drug Transporter Probe Cocktail Using the Prototypical Inhibitors Rifampin, Probenecid, Verapamil, and Cimetidine.
Wiebe Sabrina T, Giessmann Thomas, Hohl Kathrin et al. · Clin Pharmacokinet · 2020
PMID: 32504272RCTFull text (PMC)
Effect of Common Excipients on the Oral Drug Absorption of Biopharmaceutics Classification System Class 3 Drugs Cimetidine and Acyclovir.
Vaithianathan Soundarya, Haidar Sam H, Zhang Xinyuan et al. · J Pharm Sci · 2016
PMID: 26375604RCT
Effect of cimetidine, a model drug for inhibition of the organic cation transport (OCT2/MATE1) in the kidney, on the pharmacokinetics of glycopyrronium.
Dumitras Swati, Sechaud Romain, Drollmann Anton et al. · Int J Clin Pharmacol Ther · 2013
PMID: 24040847RCT
Pharmacokinetics of alogliptin when administered with food, metformin, or cimetidine: a two-phase, crossover study in healthy subjects.
Karim A, Covington P, Christopher R et al. · Int J Clin Pharmacol Ther · 2010
PMID: 20040339RCT
Pharmacokinetics of cimetidine in dogs after oral administration of cimetidine tablets.
Le Traon G, Burgaud S, Horspool L J I · J Vet Pharmacol Ther · 2009
PMID: 19646084RCT
[Effects of cimetidine on chronotropic response to cardiopulmonary exercise testing].
Rocha Gicela Risso, Stein Ricardo, Guimarães Márcio R et al. · Arq Bras Cardiol · 2006
PMID: 16612448RCT

Research data from MEDLINE/PubMed

Benefits & Expected Outcomes

Benefits, expected outcomes, efficacy data, and NNT (Number Needed to Treat) are pending physician authorship and evidence review.

Risks & Side Effects

Adverse reaction and safety data for this drug is sourced from the FDA-approved label.

View adverse reactions & drug interactions on DailyMed

Related Symptoms

Symptoms associated with conditions this intervention addresses

No related symptoms have been mapped yet. Symptom linkages are derived through associated conditions.

Alternatives & Comparisons

Alternative treatments, comparison data, and clinical decision support are pending physician authorship.

Medical Disclaimer

This information is for educational purposes only and does not constitute medical advice, diagnosis, or treatment. Always consult with a qualified healthcare provider regarding any medical condition or treatment plan.

Do not start, stop, or change any treatment without consulting your healthcare provider.

Quick Facts

Type
Substance / Medication
Fully Specified Name
Cimetidine (substance)
SNOMED CT
373541007
UMLS CUI
C0008783
RxNorm CUI
2541
Labeler
Northwind Health Company, LLC

Clinical Data

This intervention maps to 5 entities in the Healos knowledge graph.

5
Conditions
0
Biomarkers
0
Specialists
0
Symptoms

Data is sourced from SNOMED CT, UMLS, and the Healos clinical knowledge graph. Content sections marked as pending require physician authorship. Consult a healthcare provider before starting any treatment.