Substance / Medication

Clomethiazole

Overview

Active Ingredient
chlormethiazole
RxNorm CUI
2372

Indications & Related Conditions

Conditions associated via SNOMED clinical relationships

Administration & Protocol

Dosing, route, and treatment protocol

Administration details including route, dosing schedules, preparation instructions, and contraindications are pending physician authorship.

Monitoring & Follow-Up

Biomarkers relevant to this intervention via related conditions

Research Evidence

Published studies and systematic reviews

Sort:
[Which alternative to benzodiazepines, Z-pills and other hypnotics for aged people ? Melatonin, valerian, or clomethiazole].
Dumur Jean, Csajka Chantal, Pavec Ombeline et al. · Rev Med Suisse · 2018
PMID: 30422422Meta-Analysis
GABA agonist: clomethiazole.
Vaishnav Anand, Lutsep Helmi L · Curr Med Res Opin · 2002
PMID: 12365830Meta-Analysis
Treatment with clomethiazole is associated with lower rates of premature discharge during alcohol withdrawal.
Hillemacher T, Weinland C, Heberlein A et al. · Pharmacopsychiatry · 2008
PMID: 18651341RCT
Naturalistic comparison of clomethiazole and Diazepam treatment in alcohol withdrawal: effects on oxidative stress, inflammatory cytokines and hepatic biomarkers.
Strischewski David, Kalmar Amira, Guest Paul C et al. · Eur Arch Psychiatry Clin Neurosci · 2025
PMID: 38851655ObservationalFull text (PMC)
[Treatment of Alcohol Withdrawal Syndrome with Oxazepam or Clomethiazole - A Naturalistic Observational Study].
Verthein Uwe, Kuhn Silke, Gabriel Katrin et al. · Psychiatr Prax · 2018
PMID: 28371954Observational
Comparison of Clomethiazole and Diazepam in the Treatment of Alcohol Withdrawal Syndrome in Clinical Practice.
Sychla Hannah, Gründer Gerhard, Lammertz Sarah Edith · Eur Addict Res · 2017
PMID: 28898879Observational
Effects of AMPA and clomethiazole on spreading depression cycles in the rat neocortex in vivo.
Addae Jonas I, Ali Nakisha, Stone Trevor W · Eur J Pharmacol · 2011
PMID: 21147095Observational
Gamma-hydroxybutyric acid versus clomethiazole for the treatment of alcohol withdrawal syndrome in a medical intensive care unit: an open, single-center randomized study.
Elsing Christoph, Stremmel Wolfgang, Grenda Uwe et al. · Am J Drug Alcohol Abuse · 2009
PMID: 19462303Observational
Rapid and long-lasting tolerance to clomethiazole-induced hypothermia in the rat.
Visser Sandra A G, Pozarek Susanna, Martinsson Sofia et al. · Eur J Pharmacol · 2005
PMID: 15840398Observational

Research data from MEDLINE/PubMed

Benefits & Expected Outcomes

Benefits, expected outcomes, efficacy data, and NNT (Number Needed to Treat) are pending physician authorship and evidence review.

Risks & Side Effects

Risk profile, common and serious adverse effects, contraindications, and drug interactions are pending physician authorship.

Related Symptoms

Symptoms associated with conditions this intervention addresses

No related symptoms have been mapped yet. Symptom linkages are derived through associated conditions.

Alternatives & Comparisons

Alternative treatments, comparison data, and clinical decision support are pending physician authorship.

Medical Disclaimer

This information is for educational purposes only and does not constitute medical advice, diagnosis, or treatment. Always consult with a qualified healthcare provider regarding any medical condition or treatment plan.

Do not start, stop, or change any treatment without consulting your healthcare provider.

Health Goals

Goals connected through associated conditions

Quick Facts

Type
Substance / Medication
Fully Specified Name
Clomethiazole (substance)
SNOMED CT
395978007
UMLS CUI
C0008221
RxNorm CUI
2372

Clinical Data

This intervention maps to 9 entities in the Healos knowledge graph.

3
Conditions
2
Biomarkers
3
Specialists
0
Symptoms

Data is sourced from SNOMED CT, UMLS, and the Healos clinical knowledge graph. Content sections marked as pending require physician authorship. Consult a healthcare provider before starting any treatment.