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Substance / Medication

Clomipramine

SNOMED 372903001 UMLS C0009010

Overview

Active Ingredient

clomipramine

RxNorm CUI

2597

Indications & Related Conditions

Conditions associated via SNOMED clinical relationships

Depressive disorder

Obsessive-compulsive disorder

Affective psychosis

Administration & Protocol

Dosing, route, and treatment protocol

Administration details including route, dosing schedules, preparation instructions, and contraindications are pending physician authorship.

Monitoring & Follow-Up

Biomarkers relevant to this intervention via related conditions

Calcidiol+ercalcidiol

LOINC 14635-7

secondary

LOINC 2132-9

secondary

LOINC 3016-3

secondary

Clinical Trials

48 trials linked to this intervention

48

Total Trials

5

Recruiting

17

With Results

Recent Trials

Continuation Electroconvulsive Therapy Vs Medication to Prevent Relapses in Patients With Major Depressive Disorder

NCT00000375Phase 4Completed

Antidepressant Treatment of Melancholia in Late Life

NCT00000378Phase 4Completed110 enrolled

Optimizing Electroconvulsive Therapy for Depression

NCT00045916Phase 4Completed340 enrolled

Ethnic Variations in Antidepressant Response

NCT00047671Phase 4Completed400 enrolled

Research Evaluating the Value of Augmenting Medication With Psychotherapy

NCT00057551Phase 4Completed491 enrolled

View all 48 trials on ClinicalTrials.gov

Research Evidence

Published studies and systematic reviews

Sort:

Systematic Review and Meta-Analysis: Early Treatment Responses of Selective Serotonin Reuptake Inhibitors and Clomipramine in Pediatric Obsessive-Compulsive Disorder.

Varigonda Anjali L, Jakubovski Ewgeni, Bloch Michael H · J Am Acad Child Adolesc Psychiatry · 2016

PMID: 27663940Meta-AnalysisFull text (PMC)

Tolerability and adequate therapeutic dosage of oral clomipramine for the treatment of premature ejaculation: A randomized, double-blind, placebo-controlled, fixed-dose, parallel-grouped clinical study.

Kim Sae Woong, Choi Jin Bong, Kim Su Jin et al. · Int J Impot Res · 2018

PMID: 29203842RCT

Healthy individuals treated with clomipramine: an fMRI study of brain activity during autobiographical recall of emotions.

Cerqueira C T, Sato J R, de Almeida J R C et al. · Transl Psychiatry · 2014

PMID: 24984192RCTFull text (PMC)

Quetiapine versus clomipramine in the augmentation of selective serotonin reuptake inhibitors for the treatment of obsessive-compulsive disorder: a randomized, open-label trial.

Diniz J B, Shavitt R G, Pereira C A B et al. · J Psychopharmacol · 2010

PMID: 19164490RCT

The clinical effect of clomipramine in chronic idiopathic pain disorder revisited using the Spielberger State Anxiety Symptom Scale (SSASS) as outcome scale.

Bech Per, Gormsen Lise, Loldrup Dorte et al. · J Affect Disord · 2009

PMID: 19349078RCT

Mid-term effects of serial sleep deprivation therapy implemented in cognitive-behavioral treatment on the neuroendocrine response to clomipramine in patients with major depression.

Kundermann Bernd, Strate Peter, Hemmeter-Spernal Julia et al. · J Psychiatr Res · 2009

PMID: 18930473RCT

[Study on Modified Xiaoyao Decoction combining Clomipramine treating depression].

Yu Guo-han, Liang Shao-cai, Sun Qi-zhang · Zhongguo Zhong Xi Yi Jie He Za Zhi · 2007

PMID: 17526170RCT

Placebo-controlled double-blind clomipramine trial for the treatment of anxiety or fear in beagles during ground transport.

Frank Diane, Gauthier Audrey, Bergeron Renée · Can Vet J · 2006

PMID: 17147141RCTFull text (PMC)

Orthostatic side effects of clomipramine and moclobemide during treatment for depression.

Stage Kurt Bjerregaard Bjerregaard, [object Object] · Nord J Psychiatry · 2005

PMID: 16195134RCT

Distribution of clomipramine, citalopram, midazolam, and metabolites in skeletal tissue after chronic dosing in rats.

Vandenbosch Michiel, Somers Tomas, Cuypers Eva · Drug Test Anal · 2019

PMID: 30817095Observational

Research data from MEDLINE/PubMed

Benefits & Expected Outcomes

Benefits, expected outcomes, efficacy data, and NNT (Number Needed to Treat) are pending physician authorship and evidence review.

Risks & Side Effects

Risk profile, common and serious adverse effects, contraindications, and drug interactions are pending physician authorship.

Related Symptoms

Symptoms associated with conditions this intervention addresses

No related symptoms have been mapped yet. Symptom linkages are derived through associated conditions.

Alternatives & Comparisons

Alternative treatments, comparison data, and clinical decision support are pending physician authorship.

Medical Disclaimer

This information is for educational purposes only and does not constitute medical advice, diagnosis, or treatment. Always consult with a qualified healthcare provider regarding any medical condition or treatment plan.

Do not start, stop, or change any treatment without consulting your healthcare provider.

Specialists

Providers who commonly manage this intervention

Internal Medicine Physician

Internal Medicine

NUCC 207R00000X

Psychiatry Physician

Psychiatry & Neurology — Psychiatry

NUCC 2084P0800X

Find a Provider

Health Goals

Goals connected through associated conditions

Support Mental Wellness

Quick Facts

Type: Substance / Medication
Fully Specified Name: Clomipramine (substance)
SNOMED CT: 372903001
UMLS CUI: C0009010
RxNorm CUI: 2597

Clinical Data

This intervention maps to 10 entities in the Healos knowledge graph.

4

Conditions

3

Biomarkers

2

Specialists

0

Symptoms

48

Clinical Trials

Data is sourced from SNOMED CT, UMLS, and the Healos clinical knowledge graph. Content sections marked as pending require physician authorship. Consult a healthcare provider before starting any treatment.

Clomipramine — Conditions, Biomarkers & Specialists | Healos | Ltrl