Substance / Medication

Clonidine

Overview

Active Ingredient
clonidine
RxNorm CUI
2599

Indications

Clonidine transdermal system is indicated in the treatment of hypertension. It may be employed alone or concomitantly with other antihypertensive agents.

Labeler: Mayne Pharma Inc.Updated: 2025-09-04T00:00:00.000ZFull label on DailyMed

Contraindications

When this intervention should not be used

Clonidine transdermal system should not be used in patients with known hypersensitivity to clonidine or to any other component of the therapeutic system.

Indications & Related Conditions

Conditions associated via SNOMED clinical relationships

Administration & Protocol

Dosing, route, and treatment protocol

Detailed dosage and administration information is available in the full FDA drug label.

View full prescribing information on DailyMed

Monitoring & Follow-Up

Biomarkers relevant to this intervention via related conditions

Clinical Trials

156 trials linked to this intervention

156
Total Trials
17
Recruiting
59
With Results

Research Evidence

Published studies and systematic reviews

Sort:
Safety of clonidine and dexmedetomidine in peripheral nerve blocks: a systematic review of preclinical evidence.
De Cassai Alessandro, Dost Burhan, Bugada Dario et al. · Br J Anaesth · 2026
PMID: 41176463Meta-Analysis
Preoperative Oral Clonidine Enhances Surgical Field Quality During Endoscopic Sinus Surgery: A Systematic Review and Meta-Analysis With Trial Sequential Analysis.
Albazee Ebraheem, Abu-Zaid Ahmed, Alajmi Hamad et al. · Int Forum Allergy Rhinol · 2025
PMID: 40920340Meta-Analysis
Clonidine for post-traumatic stress disorder: a systematic review of the current evidence.
Marchi Mattia, Grenzi Pietro, Boks Marco P · Eur J Psychotraumatol · 2024
PMID: 38941125Meta-AnalysisFull text (PMC)
Efficacy and safety of epidural clonidine by continuous infusion or patient-controlled analgesia in labor: A meta-analysis of randomized controlled trials.
Xia Feng, Wang Li-Zhong, Chang Xiang-Yang et al. · Int J Gynaecol Obstet · 2023
PMID: 36377919Meta-Analysis
Topical clonidine for neuropathic pain in adults.
Serednicki Wojciech T, Wrzosek Anna, Woron Jaroslaw et al. · Cochrane Database Syst Rev · 2022
PMID: 35587172Meta-AnalysisFull text (PMC)
The Safety and Efficacy of Clonidine in Hemodialysis Patients: A Systematic Review and Meta-Analysis.
Derk Gwendolyn, Barton Amy, An Ruopeng et al. · Pharmacology · 2022
PMID: 36075189Meta-Analysis
Safety of clonidine used for long-term sedation in paediatric intensive care: A systematic review.
Eberl Sonja, Ahne Gabriele, Toni Irmgard et al. · Br J Clin Pharmacol · 2021
PMID: 33368604Meta-Analysis
Comparative Study of the Adverse Events Associated With Adjuvant Use of Dexmedetomidine and Clonidine in Local Anesthesia.
Jiang Jinjin, Shen Huasu, Zhang Jin et al. · Front Med (Lausanne) · 2021
PMID: 34249955Meta-AnalysisFull text (PMC)
Clonidine for pain in non-ventilated infants.
Romantsik Olga, Calevo Maria Grazia, Norman Elisabeth et al. · Cochrane Database Syst Rev · 2020
PMID: 32270873Meta-AnalysisFull text (PMC)

Research data from MEDLINE/PubMed

Benefits & Expected Outcomes

Benefits, expected outcomes, efficacy data, and NNT (Number Needed to Treat) are pending physician authorship and evidence review.

Risks & Side Effects

Adverse reaction and safety data for this drug is sourced from the FDA-approved label.

View adverse reactions & drug interactions on DailyMed

Related Symptoms

Symptoms associated with conditions this intervention addresses

No related symptoms have been mapped yet. Symptom linkages are derived through associated conditions.

Alternatives & Comparisons

Alternative treatments, comparison data, and clinical decision support are pending physician authorship.

Medical Disclaimer

This information is for educational purposes only and does not constitute medical advice, diagnosis, or treatment. Always consult with a qualified healthcare provider regarding any medical condition or treatment plan.

Do not start, stop, or change any treatment without consulting your healthcare provider.

Specialists

Providers who commonly manage this intervention

Health Goals

Goals connected through associated conditions

Quick Facts

Type
Substance / Medication
Fully Specified Name
Clonidine (substance)
SNOMED CT
372805007
UMLS CUI
C0009014
RxNorm CUI
2599
Labeler
Mayne Pharma Inc.

Clinical Data

This intervention maps to 12 entities in the Healos knowledge graph.

9
Conditions
1
Biomarkers
1
Specialists
0
Symptoms
156
Clinical Trials

Data is sourced from SNOMED CT, UMLS, and the Healos clinical knowledge graph. Content sections marked as pending require physician authorship. Consult a healthcare provider before starting any treatment.