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Substance / Medication

Coagulation factor VII

SNOMED 30804005UMLS C0015502

Overview

Active Ingredient
factor VII
RxNorm CUI
4254

Indications & Related Conditions

Conditions associated via SNOMED clinical relationships

Hemophilia A
Hereditary thromboasthenia
Factor VII deficiency
Hemophilia B
Factor IX deficiency

Administration & Protocol

Dosing, route, and treatment protocol

Administration details including route, dosing schedules, preparation instructions, and contraindications are pending physician authorship.

Monitoring & Follow-Up

Biomarkers relevant to this intervention via related conditions

No monitoring biomarkers have been mapped yet. Biomarker-intervention linkages are derived through related conditions and will expand as the knowledge graph grows.

Research Evidence

Published studies and systematic reviews

Sort:
[Correlation between polymorphisms in the coagulation factor VII gene hypervariable region 4 site and the risk of coronary heart disease in population with different ethnic backgrounds: a Meta-analysis].
Wang Li-li, Ma Bin, Qian Dun et al. · Zhonghua Liu Xing Bing Xue Za Zhi · 2013
PMID: 24518031Meta-Analysis
Association between polymorphisms in the coagulation factor VII gene and coronary heart disease risk in different ethnicities: a meta-analysis.
Mo Xingbo, Hao Yongchen, Yang Xueli et al. · BMC Med Genet · 2011
PMID: 21838885Meta-AnalysisFull text (PMC)
Pharmacokinetics and pharmacodynamics of a recombinant fusion protein linking activated coagulation factor VII with human albumin (rVIIa-FP) in patients with congenital FVII deficiency.
Gorkom Britta Laros-van, Holme Pål André, Joch Christine et al. · Hematology · 2020
PMID: 31852380Trial
Effect of Recombinant Activated Coagulation Factor VII on Hemorrhage Expansion Among Patients With Spot Sign-Positive Acute Intracerebral Hemorrhage: The SPOTLIGHT and STOP-IT Randomized Clinical Trials.
Gladstone David J, Aviv Richard I, Demchuk Andrew M et al. · JAMA Neurol · 2019
PMID: 31424491TrialFull text (PMC)
Use of activated recombinant coagulation factor VII in patients undergoing reconstruction surgery for traumatic fracture of pelvis or pelvis and acetabulum: a double-blind, randomized, placebo-controlled trial.
Raobaikady R, Redman J, Ball J A S et al. · Br J Anaesth · 2005
PMID: 15734783Trial
The effects of long-term diet and omega-3 fatty acid supplementation on coagulation factor VII and serum phospholipids with special emphasis on the R353Q polymorphism of the FVII gene.
Lindman Anja S, Pedersen Jan I, Hjerkinn Elsa M et al. · Thromb Haemost · 2004
PMID: 15175795Trial
Pharmacokinetics of activated recombinant coagulation factor VII (NovoSeven) in children vs. adults with haemophilia A.
Villar A, Aronis S, Morfini M et al. · Haemophilia · 2004
PMID: 15230949Trial
Effect of individual dietary fatty acids on postprandial activation of blood coagulation factor VII and fibrinolysis in healthy young men.
Tholstrup Tine, Miller George J, Bysted Anette et al. · Am J Clin Nutr · 2003
PMID: 12716662Trial
Effects of dietary fat quantity and composition on fasting and postprandial levels of coagulation factor VII and serum choline-containing phospholipids.
Lindman Anja Schou, Müller Hanne, Seljeflot Ingebjørg et al. · Br J Nutr · 2003
PMID: 12908893Trial
Different effects of oral contraceptives containing levonorgestrel or desogestrel on plasma lipoproteins and coagulation factor VII.
van Rooijen Marianne, von Schoultz Bo, Silveira Angela et al. · Am J Obstet Gynecol · 2002
PMID: 11810082Trial

Research data from MEDLINE/PubMed

Benefits & Expected Outcomes

Benefits, expected outcomes, efficacy data, and NNT (Number Needed to Treat) are pending physician authorship and evidence review.

Risks & Side Effects

Risk profile, common and serious adverse effects, contraindications, and drug interactions are pending physician authorship.

Related Symptoms

Symptoms associated with conditions this intervention addresses

No related symptoms have been mapped yet. Symptom linkages are derived through associated conditions.

Alternatives & Comparisons

Alternative treatments, comparison data, and clinical decision support are pending physician authorship.

Medical Disclaimer

This information is for educational purposes only and does not constitute medical advice, diagnosis, or treatment. Always consult with a qualified healthcare provider regarding any medical condition or treatment plan.

Do not start, stop, or change any treatment without consulting your healthcare provider.

Quick Facts

Type
Substance / Medication
Fully Specified Name
Coagulation factor VII (substance)
SNOMED CT
30804005
UMLS CUI
C0015502
RxNorm CUI
4254

Clinical Data

This intervention maps to 5 entities in the Ltrl knowledge graph.

5
Conditions
0
Biomarkers
0
Specialists
0
Symptoms

Data is sourced from SNOMED CT, UMLS, and the Ltrl clinical knowledge graph. Content sections marked as pending require physician authorship. Consult a healthcare provider before starting any treatment.