Substance / Medication

Cyclophosphamide

Overview

Active Ingredient
cyclophosphamide
RxNorm CUI
3002
Labeler: Cipla USA Inc.Updated: 2025-01-10T00:00:00.000ZFull label on DailyMed

Contraindications

When this intervention should not be used

Cyclophosphamide capsules are contraindicated in patients with: A history of severe hypersensitivity reactions to cyclophosphamide, any of its metabolites, or to other components of the product. Anaphylactic reactions including death have been reported with cyclophosphamide. Cross-sensitivity with o

Indications & Related Conditions

Conditions associated via SNOMED clinical relationships

Administration & Protocol

Dosing, route, and treatment protocol

Detailed dosage and administration information is available in the full FDA drug label.

View full prescribing information on DailyMed

Monitoring & Follow-Up

Biomarkers relevant to this intervention via related conditions

Clinical Trials

93 trials linked to this intervention

93
Total Trials
71
Recruiting
4
With Results

Research Evidence

Published studies and systematic reviews

Sort:
Evaluating rituximab against cyclophosphamide or cyclosporine in idiopathic membranous nephropathy: a meta-analysis.
Zhang Yin, Chen Hong, Zhang Huimin et al. · Eur J Med Res · 2025
PMID: 41351015Meta-AnalysisFull text (PMC)
Neoadjuvant dose-dense anthracycline and cyclophosphamide in combination with carboplatin, paclitaxel, and pembrolizumab for triple-negative breast cancer: a systematic review and meta-analysis.
Liutti Vitor Teixeira, do Vale David Laios, de Souza Bruno Lins et al. · Breast Cancer Res Treat · 2025
PMID: 40512324Meta-Analysis
Influence of Genetic Variation of GST, CYP, and ABC on the Safety and Efficacy of Cyclophosphamide-Based Therapy.
Yao Zhong-Wei, Li Qi-Long, Hu Wei-Feng et al. · Clin Transl Sci · 2025
PMID: 40667789Meta-AnalysisFull text (PMC)
Efficacy of cyclophosphamide for skin fibrosis in systemic sclerosis: a systematic review and single-arm meta-analysis.
Tian Xin, An PengJiao, Liu RongJi et al. · Eur J Clin Pharmacol · 2025
PMID: 40198334Meta-Analysis
Effectiveness of Cyclophosphamide and Immunosuppressants in Systemic Sclerosis-associated Interstitial Lung Disease: A Meta-analysis.
Anwar Isha, Sony Darryl, Chetry Monika et al. · J Assoc Physicians India · 2025
PMID: 40955933Meta-Analysis
A review and metanalysis of metronomic oral single-agent cyclophosphamide for treating advanced ovarian carcinoma in the era of precision medicine.
Martorana Federica, Scandurra Giuseppina, Valerio Maria Rosaria et al. · J Oncol Pharm Pract · 2024
PMID: 38018146Meta-Analysis

Research data from MEDLINE/PubMed

Benefits & Expected Outcomes

Benefits, expected outcomes, efficacy data, and NNT (Number Needed to Treat) are pending physician authorship and evidence review.

Risks & Side Effects

Adverse reaction and safety data for this drug is sourced from the FDA-approved label.

View adverse reactions & drug interactions on DailyMed

Related Symptoms

Symptoms associated with conditions this intervention addresses

No related symptoms have been mapped yet. Symptom linkages are derived through associated conditions.

Alternatives & Comparisons

Alternative treatments, comparison data, and clinical decision support are pending physician authorship.

Medical Disclaimer

This information is for educational purposes only and does not constitute medical advice, diagnosis, or treatment. Always consult with a qualified healthcare provider regarding any medical condition or treatment plan.

Do not start, stop, or change any treatment without consulting your healthcare provider.

Specialists

Providers who commonly manage this intervention

Health Goals

Goals connected through associated conditions

Quick Facts

Type
Substance / Medication
Fully Specified Name
Cyclophosphamide (substance)
SNOMED CT
387420009
UMLS CUI
C0010583
RxNorm CUI
3002
Labeler
Cipla USA Inc.

Clinical Data

This intervention maps to 25 entities in the Healos knowledge graph.

20
Conditions
3
Biomarkers
1
Specialists
0
Symptoms
93
Clinical Trials

Data is sourced from SNOMED CT, UMLS, and the Healos clinical knowledge graph. Content sections marked as pending require physician authorship. Consult a healthcare provider before starting any treatment.