Substance / Medication

Dichlorphenamide

Overview

Active Ingredient
dichlorphenamide
RxNorm CUI
3353

Indications

KEVEYIS is indicated for the treatment of primary hyperkalemic periodic paralysis, primary hypokalemic periodic paralysis, and related variants.

Labeler: Xeris Pharmaceuticals, Inc.Updated: 2025-12-23T00:00:00.000ZFull label on DailyMed

Contraindications

When this intervention should not be used

KEVEYIS is contraindicated in the following circumstances: Warnings and Precautions (5.1) [see] Hypersensitivity to dichlorphenamide or other sulfonamides Warnings and Precautions (5.2) Drug Interactions (7.1) [seeand] Concomitant use of KEVEYIS and high dose aspirin Warnings and Precautions (5.4) [

Indications & Related Conditions

Conditions associated via SNOMED clinical relationships

Administration & Protocol

Dosing, route, and treatment protocol

Detailed dosage and administration information is available in the full FDA drug label.

View full prescribing information on DailyMed

Monitoring & Follow-Up

Biomarkers relevant to this intervention via related conditions

Clinical Trials

136 trials linked to this intervention

136
Total Trials
11
Recruiting
53
With Results

Research Evidence

Published studies and systematic reviews

Sort:
Safety and efficacy of dichlorphenamide in patients with periodic paralysis: A systematic review and meta-analysis.
Haider Samna, Siddiqui Ahmed Daud, Asad Muhammad et al. · Neuromuscul Disord · 2026
PMID: 41371188Meta-Analysis
Long-term efficacy and safety of dichlorphenamide for treatment of primary periodic paralysis.
Sansone Valeria A, Johnson Nicholas E, Hanna Michael G et al. · Muscle Nerve · 2021
PMID: 34129236RCTFull text (PMC)
Efficacy and Safety of Dichlorphenamide for Primary Periodic Paralysis in Adolescents Compared With Adults.
Ciafaloni Emma, Cohen Fredric, Griggs Robert · Pediatr Neurol · 2019
PMID: 31570296Observational
Randomized, placebo-controlled trials of dichlorphenamide in periodic paralysis.
Sansone Valeria A, Burge James, McDermott Michael P et al. · Neurology · 2016
PMID: 26865514ObservationalFull text (PMC)
Marked reduction in paralytic attacks in a patient with Andersen-Tawil syndrome switched from acetazolamide to dichlorphenamide.
Gupta Anirudh, Iyadurai Stanley, Roggenbuck Jennifer et al. · Neuromuscul Disord · 2021
PMID: 34078557Case Report
Dichlorphenamide: A Review in Primary Periodic Paralyses.
Greig Sarah L · Drugs · 2016
PMID: 26941026Review
Dichlorphenamide for Refractory Hyperkalemic Periodic Paralysis.
Katyal Nakul, Singla Pratibha, Idiculla Pretty Sara et al. · J Clin Neuromuscul Dis · 2021
PMID: 34431807Other
Dichlorphenamide (Keveyis) for periodic paralysis.
Med Lett Drugs Ther · 2016
PMID: 27049510Other
A newly approved drug for a rare group of diseases: Dichlorphenamide for periodic paralysis.
Fontaine Bertrand, Phillips Lawrence H · Neurology · 2016
PMID: 26865522Other

Research data from MEDLINE/PubMed

Benefits & Expected Outcomes

Benefits, expected outcomes, efficacy data, and NNT (Number Needed to Treat) are pending physician authorship and evidence review.

Risks & Side Effects

Adverse reaction and safety data for this drug is sourced from the FDA-approved label.

View adverse reactions & drug interactions on DailyMed

Related Symptoms

Symptoms associated with conditions this intervention addresses

No related symptoms have been mapped yet. Symptom linkages are derived through associated conditions.

Alternatives & Comparisons

Alternative treatments, comparison data, and clinical decision support are pending physician authorship.

Medical Disclaimer

This information is for educational purposes only and does not constitute medical advice, diagnosis, or treatment. Always consult with a qualified healthcare provider regarding any medical condition or treatment plan.

Do not start, stop, or change any treatment without consulting your healthcare provider.

Specialists

Providers who commonly manage this intervention

Health Goals

Goals connected through associated conditions

Quick Facts

Type
Substance / Medication
Fully Specified Name
Diclofenamide (substance)
SNOMED CT
387111009
UMLS CUI
C0012086
RxNorm CUI
3353
Labeler
Xeris Pharmaceuticals, Inc.

Clinical Data

This intervention maps to 4 entities in the Healos knowledge graph.

1
Conditions
1
Biomarkers
1
Specialists
0
Symptoms
136
Clinical Trials

Data is sourced from SNOMED CT, UMLS, and the Healos clinical knowledge graph. Content sections marked as pending require physician authorship. Consult a healthcare provider before starting any treatment.