Substance / Medication

Diclofenac

Overview

Active Ingredient
diclofenac
RxNorm CUI
3355

Indications

Xiclo™ Transdermal Patch is indicated in adults over the age of 12 years old for the treatment of signs and symptoms of osteoarthritis of the joints, and of acute and chronic pain in muscles and joints associated with muscle soreness, strains, sprains, arthritis, simple backache, muscle stiffness, and more.

Labeler: Strand Health GroupUpdated: 2025-12-18T00:00:00.000ZFull label on DailyMed

Contraindications

When this intervention should not be used

Xiclo™ Transdermal Patch is contraindicated in patients with a known history of hypersensitivity to non-steroidal anti-inflammatory medications such as diclofenac. Diclofenac is contraindicated in the setting of coronary artery bypass graft (CABG) surgery. History of asthma, uticaria, or allergic-ty

Indications & Related Conditions

Conditions associated via SNOMED clinical relationships

Administration & Protocol

Dosing, route, and treatment protocol

Detailed dosage and administration information is available in the full FDA drug label.

View full prescribing information on DailyMed

Monitoring & Follow-Up

Biomarkers relevant to this intervention via related conditions

Clinical Trials

4 trials linked to this intervention

4
Total Trials
0
Recruiting
2
With Results

Research Evidence

Published studies and systematic reviews

Sort:
Diclofenac for acute postoperative pain in children.
Ringsten Martin, Kredo Tamara, Ebrahim Sumayyah et al. · Cochrane Database Syst Rev · 2023
PMID: 38078559Meta-AnalysisFull text (PMC)
Diclofenac for prophylaxis of heterotopic ossification after hip arthroplasty: a systematic review.
Haffer Henryk, Müller Michael, Ascherl Rudolf et al. · Hip Int · 2022
PMID: 33272062Meta-Analysis
Efficacy of ultramicronised diclofenac in patients with osteoarthritis - systematic review with network meta-analysis.
de Campos G C, de Almeida Macedo E, Kummer A M et al. · Eur Rev Med Pharmacol Sci · 2021
PMID: 34859865Meta-Analysis
Meta-analysis Comparing Celecoxib with Diclofenac Sodium in Patients with Knee Osteoarthritis.
Huang Hetao, Luo Minghui, Liang Haodong et al. · Pain Med · 2021
PMID: 32797224Meta-AnalysisFull text (PMC)
Effect of Combined Diclofenac and B Vitamins (Thiamine, Pyridoxine, and Cyanocobalamin) for Low Back Pain Management: Systematic Review and Meta-analysis.
Calderon-Ospina Carlos-Alberto, Nava-Mesa Mauricio Orlando, Arbeláez Ariza Carlos Emilio · Pain Med · 2020
PMID: 31529101Meta-AnalysisFull text (PMC)
Systematic review of topical diclofenac for the treatment of acute and chronic musculoskeletal pain.
Wiffen Philip J, Xia Jun · Curr Med Res Opin · 2020
PMID: 31944135Meta-Analysis
Topical Diclofenac Solution for Osteoarthritis of the Knee: An Updated Meta-Analysis of Randomized Controlled Trials.
Ling Tao, Li Jiao Jiao, Xu Rui-Juan et al. · Biomed Res Int · 2020
PMID: 33299860Meta-AnalysisFull text (PMC)
Single-dose intravenous diclofenac for acute postoperative pain in adults.
McNicol Ewan D, Ferguson McKenzie C, Schumann Roman · Cochrane Database Syst Rev · 2018
PMID: 30153336Meta-AnalysisFull text (PMC)

Research data from MEDLINE/PubMed

Benefits & Expected Outcomes

Benefits, expected outcomes, efficacy data, and NNT (Number Needed to Treat) are pending physician authorship and evidence review.

Risks & Side Effects

Adverse reaction and safety data for this drug is sourced from the FDA-approved label.

View adverse reactions & drug interactions on DailyMed

Related Symptoms

Symptoms associated with conditions this intervention addresses

No related symptoms have been mapped yet. Symptom linkages are derived through associated conditions.

Alternatives & Comparisons

Alternative treatments, comparison data, and clinical decision support are pending physician authorship.

Medical Disclaimer

This information is for educational purposes only and does not constitute medical advice, diagnosis, or treatment. Always consult with a qualified healthcare provider regarding any medical condition or treatment plan.

Do not start, stop, or change any treatment without consulting your healthcare provider.

Specialists

Providers who commonly manage this intervention

Health Goals

Goals connected through associated conditions

Quick Facts

Type
Substance / Medication
Fully Specified Name
Diclofenac (substance)
SNOMED CT
7034005
UMLS CUI
C0012091
RxNorm CUI
3355
Labeler
Strand Health Group

Clinical Data

This intervention maps to 12 entities in the Healos knowledge graph.

7
Conditions
2
Biomarkers
1
Specialists
0
Symptoms
4
Clinical Trials

Data is sourced from SNOMED CT, UMLS, and the Healos clinical knowledge graph. Content sections marked as pending require physician authorship. Consult a healthcare provider before starting any treatment.