Substance / Medication

Diphenhydramine

Overview

Active Ingredient
diphenhydramine
RxNorm CUI
3498

Indications & Related Conditions

Conditions associated via SNOMED clinical relationships

Administration & Protocol

Dosing, route, and treatment protocol

Administration details including route, dosing schedules, preparation instructions, and contraindications are pending physician authorship.

Monitoring & Follow-Up

Biomarkers relevant to this intervention via related conditions

Research Evidence

Published studies and systematic reviews

Sort:
Sedation and performance impairment of diphenhydramine and second-generation antihistamines: a meta-analysis.
Bender Bruce G, Berning Shaun, Dudden Rosalind et al. · J Allergy Clin Immunol · 2003
PMID: 12704356Meta-Analysis
Diphenhydramine, Sodium Bicarbonate, or Combination for Acute Peripheral Vertigo: A Randomized Clinical Trial.
Chi Chien-Yu, Chen Yun-Chang, Cheng Ming-Tai et al. · JAMA Netw Open · 2025
PMID: 41196596RCTFull text (PMC)
Antinociceptive and motor-blocking effects of epidurally administered diphenhydramine at different concentrations in conscious rabbits: a randomized-controlled trial.
Ziaei-Darounkolaei Navid, Hernández-Ávalos Ismael, Vahedian Vahid et al. · Lab Anim · 2025
PMID: 40876935RCT
Thermal and Cardiovascular Responses during Exertional Heat Stress after Diphenhydramine Use: A Randomized Crossover Trial.
Newhouse Douglas, Mihalcin Emily, Lefebvre Karlee et al. · Med Sci Sports Exerc · 2024
PMID: 39140777RCT

Research data from MEDLINE/PubMed

Benefits & Expected Outcomes

Benefits, expected outcomes, efficacy data, and NNT (Number Needed to Treat) are pending physician authorship and evidence review.

Risks & Side Effects

Risk profile, common and serious adverse effects, contraindications, and drug interactions are pending physician authorship.

Related Symptoms

Symptoms associated with conditions this intervention addresses

No related symptoms have been mapped yet. Symptom linkages are derived through associated conditions.

Alternatives & Comparisons

Alternative treatments, comparison data, and clinical decision support are pending physician authorship.

Medical Disclaimer

This information is for educational purposes only and does not constitute medical advice, diagnosis, or treatment. Always consult with a qualified healthcare provider regarding any medical condition or treatment plan.

Do not start, stop, or change any treatment without consulting your healthcare provider.

Health Goals

Goals connected through associated conditions

Quick Facts

Type
Substance / Medication
Fully Specified Name
Diphenhydramine (substance)
SNOMED CT
372682005
UMLS CUI
C0012522
RxNorm CUI
3498

Clinical Data

This intervention maps to 9 entities in the Healos knowledge graph.

4
Conditions
1
Biomarkers
2
Specialists
0
Symptoms

Data is sourced from SNOMED CT, UMLS, and the Healos clinical knowledge graph. Content sections marked as pending require physician authorship. Consult a healthcare provider before starting any treatment.