Substance / Medication

Ezetimibe

Overview

Active Ingredient
ezetimibe
RxNorm CUI
341248

Indications

Ezetimibe Tablets is indicated: When ezetimibe tablets is used in combination with a statin, fenofibrate, or other LDL-C lowering therapies, refer to the Prescribing Information of these products for information on the safe and effective use. • In combination with a statin, or alone when additional low-density lipoprotein cholesterol (LDL-C) lowering therapy is not possible, as an adjunct to diet to reduce elevated LDL-C in adults with primary hyperlipidemia, including heterozygous familial hype

Labeler: Major PharmaceuticalsUpdated: 2026-02-19T00:00:00.000ZFull label on DailyMed

Contraindications

When this intervention should not be used

6.2 [see Adverse Reactions ()] Ezetimibe tablets is contraindicated in patients with a known hypersensitivity to ezetimibe or any of the excipients in ezetimibe tablets. Hypersensitivity reactions including anaphylaxis, angioedema, rash, and urticaria have been reported. 5.1 [see Warnings and Precau

Indications & Related Conditions

Conditions associated via SNOMED clinical relationships

Administration & Protocol

Dosing, route, and treatment protocol

Detailed dosage and administration information is available in the full FDA drug label.

View full prescribing information on DailyMed

Monitoring & Follow-Up

Biomarkers relevant to this intervention via related conditions

No monitoring biomarkers have been mapped yet. Biomarker-intervention linkages are derived through related conditions and will expand as the knowledge graph grows.

Clinical Trials

62 trials linked to this intervention

62
Total Trials
10
Recruiting
18
With Results

Research Evidence

Published studies and systematic reviews

Sort:
Impact of Lipid-Lowering Combination Therapy With Statins and Ezetimibe vs Statin Monotherapy on the Reduction of Cardiovascular Outcomes: A Meta-analysis.
Banach Maciej, Jaiswal Vikash, Ang Song Peng et al. · Mayo Clin Proc · 2025
PMID: 40126455Meta-Analysis
Ezetimibe and the risk of new-onset type 2 diabetes: a systematic review and meta-analysis.
Albawa'neh Areej S, Alqasrawi Mais N, Al-Mahayri Zeina N et al. · Ann Med · 2025
PMID: 41320800Meta-AnalysisFull text (PMC)
Efficacy and Safety of Ezetimibe for Non-Alcoholic Fatty Liver Disease: A Systematic Review and Meta-Analysis.
Boskabadi Amir Reza, Khodabandelu Sajad, Rahimi Yasaman et al. · Curr Rev Clin Exp Pharmacol · 2025
PMID: 40530735Meta-Analysis
Potential impact of ezetimibe on patients with NAFLD/NASH: a meta-analysis of randomized controlled trials.
Jiao BoLun, Wang Bing, Liu BoYan et al. · Front Endocrinol (Lausanne) · 2024
PMID: 39439571Meta-AnalysisFull text (PMC)

Research data from MEDLINE/PubMed

Benefits & Expected Outcomes

Benefits, expected outcomes, efficacy data, and NNT (Number Needed to Treat) are pending physician authorship and evidence review.

Risks & Side Effects

Adverse reaction and safety data for this drug is sourced from the FDA-approved label.

View adverse reactions & drug interactions on DailyMed

Related Symptoms

Symptoms associated with conditions this intervention addresses

No related symptoms have been mapped yet. Symptom linkages are derived through associated conditions.

Alternatives & Comparisons

Alternative treatments, comparison data, and clinical decision support are pending physician authorship.

Medical Disclaimer

This information is for educational purposes only and does not constitute medical advice, diagnosis, or treatment. Always consult with a qualified healthcare provider regarding any medical condition or treatment plan.

Do not start, stop, or change any treatment without consulting your healthcare provider.

Quick Facts

Type
Substance / Medication
Fully Specified Name
Ezetimibe (substance)
SNOMED CT
409149001
UMLS CUI
C1142985
RxNorm CUI
341248
Labeler
Major Pharmaceuticals

Clinical Data

This intervention maps to 5 entities in the Ltrl knowledge graph.

5
Conditions
0
Biomarkers
0
Specialists
0
Symptoms
62
Clinical Trials

Data is sourced from SNOMED CT, UMLS, and the Ltrl clinical knowledge graph. Content sections marked as pending require physician authorship. Consult a healthcare provider before starting any treatment.