Substance / Medication

Felodipine

Overview

Active Ingredient
felodipine
RxNorm CUI
4316

Indications

Felodipine tablets are indicated for the treatment of hypertension, to lower blood pressure. Lowering blood pressure lowers the risk of fatal and non-fatal cardiovascular events, primarily strokes and myocardial infarctions. These benefits have been seen in controlled trials of antihypertensive drugs from a wide variety of pharmacologic classes including felodipine. Control of high blood pressure should be part of comprehensive cardiovascular risk management, including, as appropriate, lipid con

Labeler: Glenmark Pharmaceuticals Inc., USAUpdated: 2026-01-23T00:00:00.000ZFull label on DailyMed

Contraindications

When this intervention should not be used

Felodipine is contraindicated in patients who are hypersensitive to this product.

Indications & Related Conditions

Conditions associated via SNOMED clinical relationships

Administration & Protocol

Dosing, route, and treatment protocol

Detailed dosage and administration information is available in the full FDA drug label.

View full prescribing information on DailyMed

Monitoring & Follow-Up

Biomarkers relevant to this intervention via related conditions

No monitoring biomarkers have been mapped yet. Biomarker-intervention linkages are derived through related conditions and will expand as the knowledge graph grows.

Clinical Trials

4 trials linked to this intervention

4
Total Trials
0
Recruiting
1
With Results

Research Evidence

Published studies and systematic reviews

Sort:
Publication bias on clinical studies of pharmacokinetic interactions between felodipine and grapefruit juice.
Uesawa Y, Takeuchi T, Mohri K · Pharmazie · 2010
PMID: 20503932Meta-Analysis
Felodipine and renal function in lung transplantation: A randomized placebo-controlled trial.
Hornum Mads, Iversen Martin, Oturai Peter et al. · J Heart Lung Transplant · 2020
PMID: 32061508RCT
Coffee-Antihypertensive Drug Interaction: A Hemodynamic and Pharmacokinetic Study With Felodipine.
Bailey David G, Dresser George K, Urquhart Brad L et al. · Am J Hypertens · 2016
PMID: 27481881RCT
Pharmacokinetics of felodipine extended-release tablets in healthy Taiwanese subjects: a retrospective review.
Hsiao Chia-Ling, Wu Ya-Chi, Hsu Kuang-Yang · Arzneimittelforschung · 2011
PMID: 21950148RCT
A furanocoumarin-free grapefruit juice establishes furanocoumarins as the mediators of the grapefruit juice-felodipine interaction.
Paine Mary F, Widmer Wilbur W, Hart Heather L et al. · Am J Clin Nutr · 2006
PMID: 16685052RCT

Research data from MEDLINE/PubMed

Benefits & Expected Outcomes

Benefits, expected outcomes, efficacy data, and NNT (Number Needed to Treat) are pending physician authorship and evidence review.

Risks & Side Effects

Adverse reaction and safety data for this drug is sourced from the FDA-approved label.

View adverse reactions & drug interactions on DailyMed

Related Symptoms

Symptoms associated with conditions this intervention addresses

No related symptoms have been mapped yet. Symptom linkages are derived through associated conditions.

Alternatives & Comparisons

Alternative treatments, comparison data, and clinical decision support are pending physician authorship.

Medical Disclaimer

This information is for educational purposes only and does not constitute medical advice, diagnosis, or treatment. Always consult with a qualified healthcare provider regarding any medical condition or treatment plan.

Do not start, stop, or change any treatment without consulting your healthcare provider.

Quick Facts

Type
Substance / Medication
Fully Specified Name
Felodipine (substance)
SNOMED CT
386863007
UMLS CUI
C0015772
RxNorm CUI
4316
Labeler
Glenmark Pharmaceuticals Inc., USA

Clinical Data

This intervention maps to 2 entities in the Healos knowledge graph.

2
Conditions
0
Biomarkers
0
Specialists
0
Symptoms
4
Clinical Trials

Data is sourced from SNOMED CT, UMLS, and the Healos clinical knowledge graph. Content sections marked as pending require physician authorship. Consult a healthcare provider before starting any treatment.