Substance / Medication

Fluconazole

Overview

Active Ingredient
fluconazole
RxNorm CUI
4450

Indications

Fluconazole tablets are indicated for the treatment of: Prophylaxis: Fluconazole tablets are also indicated to decrease the incidence of candidiasis in patients undergoing bone marrow transplantation who receive cytotoxic chemotherapy and/or radiation therapy.Specimens for fungal culture and other relevant laboratory studies (serology, histopathology) should be obtained prior to therapy to isolate and identify causative organisms. Therapy may be instituted before the results of the cultures an

Labeler: A-S Medication SolutionsUpdated: 2026-02-17T00:00:00.000ZFull label on DailyMed

Contraindications

When this intervention should not be used

CLINICAL PHARMACOLOGY: Drug Interaction Studies PRECAUTIONS Fluconazole tablets are contraindicated in patients who have shown hypersensitivity to fluconazole or to any of its excipients. There is no information regarding cross-hypersensitivity between fluconazole and other azole antifungal agents.

Indications & Related Conditions

Conditions associated via SNOMED clinical relationships

Administration & Protocol

Dosing, route, and treatment protocol

Detailed dosage and administration information is available in the full FDA drug label.

View full prescribing information on DailyMed

Monitoring & Follow-Up

Biomarkers relevant to this intervention via related conditions

Clinical Trials

17 trials linked to this intervention

17
Total Trials
5
Recruiting
4
With Results

Research Evidence

Published studies and systematic reviews

Sort:
Risk of congenital malformations and miscarriages following maternal use of oral fluconazole during the first trimester of pregnancy: a systematic review and meta-analysis.
Latour Mathilde, Vauzelle Catherine, Elefant Elisabeth et al. · Eur J Epidemiol · 2024
PMID: 39658659Meta-Analysis
Maternal use of fluconazole and congenital malformations in the progeny: A meta-analysis of the literature.
Budani Maria Cristina, Fensore Stefania, Di Marzio Marco et al. · Reprod Toxicol · 2021
PMID: 33383164Meta-Analysis
[Efficacy and safety of fluconazole in prophylaxis of invasive fungal infections in very low birth weight infants: a Meta analysis].
Xia Xu-Hua, Lin Lu, Zi-Yu Hua · Zhongguo Dang Dai Er Ke Za Zhi · 2020
PMID: 32434639Meta-AnalysisFull text (PMC)
The safety of oral fluconazole during the first trimester of pregnancy: a systematic review and meta-analysis.
Zhang Z, Zhang X, Zhou Y-Y et al. · BJOG · 2019
PMID: 31446677Meta-Analysis
A systematic review of fluconazole resistance in clinical isolates of Cryptococcus species.
Bongomin Felix, Oladele Rita O, Gago Sara et al. · Mycoses · 2018
PMID: 29377368Meta-Analysis
Fluconazole Prophylaxis for the Prevention of Candidiasis in Premature Infants: A Meta-analysis Using Patient-level Data.
Ericson Jessica E, Kaufman David A, Kicklighter Stephen D et al. · Clin Infect Dis · 2016
PMID: 27298330Meta-AnalysisFull text (PMC)

Research data from MEDLINE/PubMed

Benefits & Expected Outcomes

Benefits, expected outcomes, efficacy data, and NNT (Number Needed to Treat) are pending physician authorship and evidence review.

Risks & Side Effects

Adverse reaction and safety data for this drug is sourced from the FDA-approved label.

View adverse reactions & drug interactions on DailyMed

Related Symptoms

Symptoms associated with conditions this intervention addresses

No related symptoms have been mapped yet. Symptom linkages are derived through associated conditions.

Alternatives & Comparisons

Alternative treatments, comparison data, and clinical decision support are pending physician authorship.

Medical Disclaimer

This information is for educational purposes only and does not constitute medical advice, diagnosis, or treatment. Always consult with a qualified healthcare provider regarding any medical condition or treatment plan.

Do not start, stop, or change any treatment without consulting your healthcare provider.

Health Goals

Goals connected through associated conditions

Quick Facts

Type
Substance / Medication
Fully Specified Name
Fluconazole (substance)
SNOMED CT
387174006
UMLS CUI
C0016277
RxNorm CUI
4450
Labeler
A-S Medication Solutions

Clinical Data

This intervention maps to 15 entities in the Healos knowledge graph.

10
Conditions
2
Biomarkers
2
Specialists
0
Symptoms
17
Clinical Trials

Data is sourced from SNOMED CT, UMLS, and the Healos clinical knowledge graph. Content sections marked as pending require physician authorship. Consult a healthcare provider before starting any treatment.