Substance / Medication

Fosphenytoin

Overview

Active Ingredient
fosphenytoin
RxNorm CUI
72236

Indications & Related Conditions

Conditions associated via SNOMED clinical relationships

Administration & Protocol

Dosing, route, and treatment protocol

Administration details including route, dosing schedules, preparation instructions, and contraindications are pending physician authorship.

Monitoring & Follow-Up

Biomarkers relevant to this intervention via related conditions

No monitoring biomarkers have been mapped yet. Biomarker-intervention linkages are derived through related conditions and will expand as the knowledge graph grows.

Clinical Trials

91 trials linked to this intervention

91
Total Trials
16
Recruiting
33
With Results

Research Evidence

Published studies and systematic reviews

Sort:
Levetiracetam Versus Phenytoin or Fosphenytoin for Second-Line Treatment of Pediatric Status Epilepticus: A Meta-Analysis.
Klowak Jennifer Ann, Hewitt Mark, Catenacci Vanessa et al. · Pediatr Crit Care Med · 2021
PMID: 33710073Meta-Analysis
Clinical Effectiveness of Levetiracetam Compared to Fosphenytoin in the Treatment of Benzodiazepine Refractory Convulsive Status Epilepticus.
Nalisetty Sricharantheja, Kandasamy Sasidaran, Sridharan Balaji et al. · Indian J Pediatr · 2020
PMID: 32088913RCT
Canine status epilepticus treated with fosphenytoin: A proof of principle study.
Patterson Edward E, Leppik Ilo E, Coles Lisa D et al. · Epilepsia · 2015
PMID: 25953073RCTFull text (PMC)
Fosphenytoin for seizure prevention in childhood coma in Africa: a randomized clinical trial.
Gwer Samson A, Idro Richard I, Fegan Gregory et al. · J Crit Care · 2013
PMID: 24135012RCTFull text (PMC)
Bioavailability of intravenous fosphenytoin sodium in healthy Japanese volunteers.
Inoue Yushi, Usui Naotaka, Hiroki Tadayuki et al. · Eur J Drug Metab Pharmacokinet · 2013
PMID: 22968854RCTFull text (PMC)
The Impact of Standard Versus Weight-Based Maintenance Dosing of Fosphenytoin on Achieving Therapeutic Drug Levels.
Milby Madison, Kwarciany Theresa, Jarboe Lindsey et al. · J Clin Pharmacol · 2025
PMID: 40437649Observational

Research data from MEDLINE/PubMed

Benefits & Expected Outcomes

Benefits, expected outcomes, efficacy data, and NNT (Number Needed to Treat) are pending physician authorship and evidence review.

Risks & Side Effects

Risk profile, common and serious adverse effects, contraindications, and drug interactions are pending physician authorship.

Related Symptoms

Symptoms associated with conditions this intervention addresses

No related symptoms have been mapped yet. Symptom linkages are derived through associated conditions.

Alternatives & Comparisons

Alternative treatments, comparison data, and clinical decision support are pending physician authorship.

Medical Disclaimer

This information is for educational purposes only and does not constitute medical advice, diagnosis, or treatment. Always consult with a qualified healthcare provider regarding any medical condition or treatment plan.

Do not start, stop, or change any treatment without consulting your healthcare provider.

Quick Facts

Type
Substance / Medication
Fully Specified Name
Fosphenytoin (substance)
SNOMED CT
372484000
UMLS CUI
C0244656
RxNorm CUI
72236

Clinical Data

This intervention maps to 2 entities in the Healos knowledge graph.

2
Conditions
0
Biomarkers
0
Specialists
0
Symptoms
91
Clinical Trials

Data is sourced from SNOMED CT, UMLS, and the Healos clinical knowledge graph. Content sections marked as pending require physician authorship. Consult a healthcare provider before starting any treatment.