Substance / Medication

Fostamatinib

Overview

Active Ingredient
fostamatinib
RxNorm CUI
2044896

Indications

TAVALISSE is indicated for the treatment of thrombocytopenia in adult patients with chronic immune thrombocytopenia (ITP) who have had an insufficient response to a previous treatment.

Labeler: Rigel Pharmaceuticals, Inc.Updated: 2025-11-05T00:00:00.000ZFull label on DailyMed

Contraindications

When this intervention should not be used

None.

Indications & Related Conditions

Conditions associated via SNOMED clinical relationships

Administration & Protocol

Dosing, route, and treatment protocol

Detailed dosage and administration information is available in the full FDA drug label.

View full prescribing information on DailyMed

Monitoring & Follow-Up

Biomarkers relevant to this intervention via related conditions

Clinical Trials

14 trials linked to this intervention

14
Total Trials
5
Recruiting
2
With Results

Research Evidence

Published studies and systematic reviews

Sort:
Efficacy and safety of fostamatinib in refractory immune thrombocytopenia: a meta-analysis from randomized controlled trials.
Tungjitviboonkun Songphol, Bumrungratanayos Naharuthai, Jitwimungsanon Jedsadakorn et al. · Ann Hematol · 2024
PMID: 38856778Meta-AnalysisFull text (PMC)
Fostamatinib, an oral spleen tyrosine kinase inhibitor, in the treatment of rheumatoid arthritis: a meta-analysis of randomized controlled trials.
Kunwar Sumit, Devkota Ashok Raj, Ghimire Dipesh K C · Rheumatol Int · 2016
PMID: 27113955Meta-Analysis
Fostamatinib for Hospitalized Adults With COVID-19 and Hypoxemia: A Randomized Clinical Trial.
Collins Sean P, Shotwell Matthew S, Strich Jeffrey R et al. · JAMA Netw Open · 2024
PMID: 39625722RCTFull text (PMC)
Fostamatinib for warm antibody autoimmune hemolytic anemia: Phase 3, randomized, double-blind, placebo-controlled, global study (FORWARD).
Kuter David J, Piatek Caroline, Röth Alexander et al. · Am J Hematol · 2024
PMID: 37929318RCT
Fostamatinib for the Treatment of Hospitalized Adults With Coronavirus Disease 2019: A Randomized Trial.
Strich Jeffrey R, Tian Xin, Samour Mohamed et al. · Clin Infect Dis · 2022
PMID: 34467402RCTFull text (PMC)
Post-marketing safety surveillance of fostamatinib: an observational, pharmacovigilance study leveraging FAERS database.
Wei Wei, Bai Ying-Tao, Chang En et al. · Expert Opin Drug Saf · 2025
PMID: 39078338Observational
Real-world efficacy and safety of fostamatinib in ITP patients: Italian multicentre experience. GIMEMA ITP1122 study.
Lucchini Elisa, Vianelli Nicola, Consoli Ugo et al. · Br J Haematol · 2025
PMID: 40855761Observational

Research data from MEDLINE/PubMed

Benefits & Expected Outcomes

Benefits, expected outcomes, efficacy data, and NNT (Number Needed to Treat) are pending physician authorship and evidence review.

Risks & Side Effects

Adverse reaction and safety data for this drug is sourced from the FDA-approved label.

View adverse reactions & drug interactions on DailyMed

Related Symptoms

Symptoms associated with conditions this intervention addresses

No related symptoms have been mapped yet. Symptom linkages are derived through associated conditions.

Alternatives & Comparisons

Alternative treatments, comparison data, and clinical decision support are pending physician authorship.

Medical Disclaimer

This information is for educational purposes only and does not constitute medical advice, diagnosis, or treatment. Always consult with a qualified healthcare provider regarding any medical condition or treatment plan.

Do not start, stop, or change any treatment without consulting your healthcare provider.

Health Goals

Goals connected through associated conditions

Quick Facts

Type
Substance / Medication
Fully Specified Name
Fostamatinib (substance)
SNOMED CT
772033003
UMLS CUI
C2713632
RxNorm CUI
2044896
Labeler
Rigel Pharmaceuticals, Inc.

Clinical Data

This intervention maps to 7 entities in the Healos knowledge graph.

1
Conditions
3
Biomarkers
2
Specialists
0
Symptoms
14
Clinical Trials

Data is sourced from SNOMED CT, UMLS, and the Healos clinical knowledge graph. Content sections marked as pending require physician authorship. Consult a healthcare provider before starting any treatment.