Substance / Medication

Human fibrinogen

Overview

Clinical overview including description, indications, and evidence base is pending physician authorship or FDA SPL integration. Graph-derived relationship data is available below.

Indications & Related Conditions

Conditions associated via SNOMED clinical relationships

Afibrinogenaemia

Administration & Protocol

Dosing, route, and treatment protocol

Administration details including route, dosing schedules, preparation instructions, and contraindications are pending physician authorship.

Monitoring & Follow-Up

Biomarkers relevant to this intervention via related conditions

No monitoring biomarkers have been mapped yet. Biomarker-intervention linkages are derived through related conditions and will expand as the knowledge graph grows.

Research Evidence

Published studies and systematic reviews

Sort:

Diagnostic accuracy of viscoelastic point-of-care identification of hypofibrinogenaemia in cardiac surgical patients: A systematic review.

Gibbs Neville M, Weightman William M · Anaesth Intensive Care · 2020

PMID: 33016097Meta-Analysis

Obstetrical and postpartum complications in women with hereditary fibrinogen disorders: A systematic literature review.

Valiton Vivian, Hugon-Rodin Justine, Fontana Pierre et al. · Haemophilia · 2019

PMID: 31368232Meta-Analysis

Thromboembolism in patients with congenital afibrinogenaemia. Long-term observational data and systematic review.

Nagler Michael, Kremer Hovinga Johanna A, Alberio Lorenzo et al. · Thromb Haemost · 2016

PMID: 27384135Meta-Analysis

A Randomized Pilot Trial Assessing the Role of Human Fibrinogen Concentrate in Decreasing Cryoprecipitate Use and Blood Loss in Infants Undergoing Cardiopulmonary Bypass.

Tirotta Christopher F, Lagueruela Richard G, Gupta Apeksha et al. · Pediatr Cardiol · 2022

PMID: 35305111RCTFull text (PMC)

Efficacy and safety of fibrinogen administration in acute post-traumatic hypofibrinogenemia in isolated severe traumatic brain injury: A randomized clinical trial.

Sabouri Masih, Vahidian Mahdi, Sourani Arman et al. · J Clin Neurosci · 2022

PMID: 35642832RCT

Practice patterns of ABO-matching for cryoprecipitate and patient outcomes after ABO-compatible versus incompatible cryoprecipitate.

Raycraft Tyler, Bartoszko Justyna, Karkouti Keyvan et al. · Vox Sang · 2022

PMID: 35791670RCT

[Indication and technique of human fibrinogen/thrombin-coated collagen patch use in mucogingival surgery].

Zorina O A, Molchanov A M, Balykin R A · Stomatologiia (Mosk) · 2014

PMID: 25377582RCT

Efficacy and safety of a new human fibrinogen concentrate in patients with congenital fibrinogen deficiency: an interim analysis of a Phase III trial.

Lissitchkov Toshko, Madan Bella, Djambas Khayat Claudia et al. · Transfusion · 2018

PMID: 29194665Trial

Human fibrinogen patches application reduces intra-abdominal infectious complications in pancreas transplant with enteric drainage.

Padillo J, Arjona-Sánchez A, Ruiz-Rabelo J et al. · World J Surg · 2010

PMID: 20811746Trial

Efficacy and safety of topical application of human fibrinogen/thrombin-coated collagen patch (TachoComb) for treatment of air leakage after standard lobectomy.

Lang György, Csekeö Attila, Stamatis Georgios et al. · Eur J Cardiothorac Surg · 2004

PMID: 14747106Trial

Research data from MEDLINE/PubMed

Benefits & Expected Outcomes

Benefits, expected outcomes, efficacy data, and NNT (Number Needed to Treat) are pending physician authorship and evidence review.

Risks & Side Effects

Risk profile, common and serious adverse effects, contraindications, and drug interactions are pending physician authorship.

Related Symptoms

Symptoms associated with conditions this intervention addresses

No related symptoms have been mapped yet. Symptom linkages are derived through associated conditions.

Alternatives & Comparisons

Alternative treatments, comparison data, and clinical decision support are pending physician authorship.

Medical Disclaimer

This information is for educational purposes only and does not constitute medical advice, diagnosis, or treatment. Always consult with a qualified healthcare provider regarding any medical condition or treatment plan.

Do not start, stop, or change any treatment without consulting your healthcare provider.

Quick Facts

Type: Substance / Medication
Fully Specified Name: Human fibrinogen (substance)
SNOMED CT: 418326009
UMLS CUI: C2587184

Clinical Data

This intervention maps to 1 entities in the Ltrl knowledge graph.

Conditions

Biomarkers

Specialists

Symptoms

Data is sourced from SNOMED CT, UMLS, and the Ltrl clinical knowledge graph. Content sections marked as pending require physician authorship. Consult a healthcare provider before starting any treatment.