Substance / Medication

Lurbinectedin

Overview

Active Ingredient
lurbinectedin
RxNorm CUI
2374729
Labeler: Jazz Pharmaceuticals, Inc.Updated: 2025-10-02T00:00:00.000ZFull label on DailyMed

Contraindications

When this intervention should not be used

None.

Indications & Related Conditions

Conditions associated via SNOMED clinical relationships

Administration & Protocol

Dosing, route, and treatment protocol

Detailed dosage and administration information is available in the full FDA drug label.

View full prescribing information on DailyMed

Monitoring & Follow-Up

Biomarkers relevant to this intervention via related conditions

No monitoring biomarkers have been mapped yet. Biomarker-intervention linkages are derived through related conditions and will expand as the knowledge graph grows.

Research Evidence

Published studies and systematic reviews

Sort:
Indirect treatment comparison of lurbinectedin versus other second-line treatments for small-cell lung cancer.
Hanvesakul Raj, Rengarajan Badri, Naveh Navit et al. · J Comp Eff Res · 2023
PMID: 37079341Meta-AnalysisFull text (PMC)
Phase I results on the efficacy, safety and pharmacokinetics of lurbinectedin and irinotecan in advanced solid tumors.
Falcón Alejandro, Ponce Santiago, Cote Gregory M et al. · Invest New Drugs · 2025
PMID: 40963055TrialFull text (PMC)
Lurbinectedin Plus Pembrolizumab in Relapsed SCLC: The Phase I/II LUPER Study.
Calles Antonio, Navarro Alejandro, Doger de Speville Uribe Bernard Gaston et al. · J Thorac Oncol · 2025
PMID: 39938593Trial
Pharmacokinetics and Safety of Lurbinectedin Administrated with Itraconazole in Cancer Patients: A Drug-Drug Interaction Study.
Moreno Irene, Hernández Tatiana, Calvo Emiliano et al. · Mar Drugs · 2024
PMID: 38667795TrialFull text (PMC)

Research data from MEDLINE/PubMed

Benefits & Expected Outcomes

Benefits, expected outcomes, efficacy data, and NNT (Number Needed to Treat) are pending physician authorship and evidence review.

Risks & Side Effects

Adverse reaction and safety data for this drug is sourced from the FDA-approved label.

View adverse reactions & drug interactions on DailyMed

Related Symptoms

Symptoms associated with conditions this intervention addresses

No related symptoms have been mapped yet. Symptom linkages are derived through associated conditions.

Alternatives & Comparisons

Alternative treatments, comparison data, and clinical decision support are pending physician authorship.

Medical Disclaimer

This information is for educational purposes only and does not constitute medical advice, diagnosis, or treatment. Always consult with a qualified healthcare provider regarding any medical condition or treatment plan.

Do not start, stop, or change any treatment without consulting your healthcare provider.

Quick Facts

Type
Substance / Medication
Fully Specified Name
Lurbinectedin (substance)
SNOMED CT
879925002
UMLS CUI
C3898565
RxNorm CUI
2374729
Labeler
Jazz Pharmaceuticals, Inc.

Clinical Data

This intervention maps to 1 entities in the Ltrl knowledge graph.

1
Conditions
0
Biomarkers
0
Specialists
0
Symptoms

Data is sourced from SNOMED CT, UMLS, and the Ltrl clinical knowledge graph. Content sections marked as pending require physician authorship. Consult a healthcare provider before starting any treatment.