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Substance / Medication

Medium chain triglycerides

SNOMED 395781005 UMLS C0724624

Overview

Active Ingredient

medium chain triglycerides

RxNorm CUI

1310578

Indications & Related Conditions

Conditions associated via SNOMED clinical relationships

Cystic fibrosis

Coeliac disease

Administration & Protocol

Dosing, route, and treatment protocol

Administration details including route, dosing schedules, preparation instructions, and contraindications are pending physician authorship.

Monitoring & Follow-Up

Biomarkers relevant to this intervention via related conditions

C reactive protein

LOINC 1988-5

secondary

LOINC 49765-1

secondary

Alanine aminotransferase

LOINC 1742-6

primary

Tissue transglutaminase Ab panel

LOINC 31017-7

primary

Clinical Trials

87 trials linked to this intervention

87

Total Trials

19

Recruiting

31

With Results

Recent Trials

Role of Genetic Factors in the Development of Lung Disease

NCT00001532Recruiting3500 enrolled

Vasoconstrictors as Alternatives to Albumin After Large-Volume Paracentesis (LVP) in Cirrhosis

NCT00108355Phase 4Completed29 enrolled

Study of Alendronate to Prevent and Treat Osteoporosis in Cystic Fibrosis Patients

NCT00157690Phase 4Completed56 enrolled

Cystic Fibrosis and Totally Implantable Vascular Access Devices

NCT00244270Phase 4Completed97 enrolled

Genetic Disorders of Mucociliary Clearance in Nontuberculous Mycobacterial Lung Disease

NCT00368446Completed87 enrolled

View all 87 trials on ClinicalTrials.gov

Research Evidence

Published studies and systematic reviews

Sort:

Medium Chain Triglycerides induce mild ketosis and may improve cognition in Alzheimer's disease. A systematic review and meta-analysis of human studies.

Avgerinos Konstantinos I, Egan Josephine M, Mattson Mark P et al. · Ageing Res Rev · 2020

PMID: 31870908Meta-AnalysisFull text (PMC)

Medium chain triglycerides with a C8:C10 ratio of 30:70 enhances cognitive performance and mitigates the cognitive decline associated with prolonged exercise in young and healthy adults.

Ashton Jake S, Roberts James W, Wakefield Caroline J et al. · Physiol Behav · 2023

PMID: 37394051RCT

Ketogenic Effects of Multiple Doses of a Medium Chain Triglycerides Enriched Ketogenic Formula in Healthy Men under the Ketogenic Diet: A Randomized, Double-Blinded, Placebo-Controlled Study.

Nakamura Kentaro, Hagihara Keisuke, Nagai Naoko et al. · Nutrients · 2022

PMID: 35334856RCTFull text (PMC)

Lack of toxicity by medium chain triglycerides (MCT) in canines during a 90-day feeding study.

Matulka Ray A, Thompson D V M Larry, Burdock George A · Food Chem Toxicol · 2009

PMID: 19135768RCT

Medium chain triglycerides alleviate non-alcoholic fatty liver disease through bile acid-mediated FXR signaling pathway: A comparative study with common vegetable edible oils.

Yue Hao, Jia Min, Li Baorui et al. · J Food Sci · 2024

PMID: 39668111Observational

Effect of medium chain triglycerides enriched formula on growth of biliary atresia patients after Kasai portoenterostomy.

El-Koofy Nehal, Mahmoud Eman, El Mougy Fatma et al. · Arab J Gastroenterol · 2024

PMID: 38378358Observational

Medium chain triglycerides as vehicle for palatable oral liquids.

Bahal Surendra M, Romansky Jamie M, Alvarez Francisco J · Pharm Dev Technol · 2003

PMID: 12665204Observational

Thirty-Three Years Follow-Up of a Greek Family with Abetalipoproteinemia: Absence of Liver Damage on Long-Term Medium Chain Triglycerides Supplementation.

Triantafillidis John K, Manioti Areti, Pittaras Theodoros et al. · J Pers Med · 2025

PMID: 40863416Case ReportFull text (PMC)

Evidence for medium chain triglycerides in the treatment of primary intestinal lymphangiectasia.

Desai A P, Guvenc B H, Carachi R · Eur J Pediatr Surg · 2009

PMID: 19449286Case Report

AQbD-Based UPLC-ELSD Method for Quantifying Medium Chain Triglycerides in Labrafac™ WL 1349 for Nanoemulsion Applications.

Gaggero Alessio, Marko Viktoria, Jeremic Dalibor et al. · Molecules · 2025

PMID: 39942593OtherFull text (PMC)

Research data from MEDLINE/PubMed

Benefits & Expected Outcomes

Benefits, expected outcomes, efficacy data, and NNT (Number Needed to Treat) are pending physician authorship and evidence review.

Risks & Side Effects

Risk profile, common and serious adverse effects, contraindications, and drug interactions are pending physician authorship.

Related Symptoms

Symptoms associated with conditions this intervention addresses

No related symptoms have been mapped yet. Symptom linkages are derived through associated conditions.

Alternatives & Comparisons

Alternative treatments, comparison data, and clinical decision support are pending physician authorship.

Medical Disclaimer

This information is for educational purposes only and does not constitute medical advice, diagnosis, or treatment. Always consult with a qualified healthcare provider regarding any medical condition or treatment plan.

Do not start, stop, or change any treatment without consulting your healthcare provider.

Specialists

Providers who commonly manage this intervention

Allergy & Immunology (Internal Medicine) Physician

Internal Medicine — Allergy & Immunology

NUCC 207RA0201X

Endocrinology, Diabetes & Metabolism Physician

Internal Medicine — Endocrinology, Diabetes & Metabolism

NUCC 207RE0101X

Gastroenterology Physician

Internal Medicine — Gastroenterology

NUCC 207RG0100X

Rheumatology Physician

Internal Medicine — Rheumatology

NUCC 207RR0500X

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Health Goals

Goals connected through associated conditions

Improve Gut Health Promote Healthy Aging Strengthen Bone Health

Quick Facts

Type: Substance / Medication
Fully Specified Name: Medium chain triglyceride (substance)
SNOMED CT: 395781005
UMLS CUI: C0724624
RxNorm CUI: 1310578

Clinical Data

This intervention maps to 18 entities in the Ltrl knowledge graph.

7

Conditions

4

Biomarkers

4

Specialists

0

Symptoms

87

Clinical Trials

Data is sourced from SNOMED CT, UMLS, and the Ltrl clinical knowledge graph. Content sections marked as pending require physician authorship. Consult a healthcare provider before starting any treatment.