Substance / Medication

Megestrol acetate

Overview

Clinical overview including description, indications, and evidence base is pending physician authorship or FDA SPL integration. Graph-derived relationship data is available below.

Indications & Related Conditions

Conditions associated via SNOMED clinical relationships

Administration & Protocol

Dosing, route, and treatment protocol

Administration details including route, dosing schedules, preparation instructions, and contraindications are pending physician authorship.

Monitoring & Follow-Up

Biomarkers relevant to this intervention via related conditions

No monitoring biomarkers have been mapped yet. Biomarker-intervention linkages are derived through related conditions and will expand as the knowledge graph grows.

Clinical Trials

5 trials linked to this intervention

5
Total Trials
2
Recruiting
1
With Results

Research Evidence

Published studies and systematic reviews

Sort:
Dose-dependent effect of megestrol acetate supplementation in cancer patients with anorexia-cachexia syndrome: A meta-analysis.
Talebi Sepide, Zeraattalab-Motlagh Sheida, Barkhordar Maryam et al. · J Cachexia Sarcopenia Muscle · 2024
PMID: 39031821Meta-AnalysisFull text (PMC)
Megestrol acetate for cachexia-anorexia syndrome. A systematic review.
Ruiz-García Vicente, López-Briz Eduardo, Carbonell-Sanchis Rafael et al. · J Cachexia Sarcopenia Muscle · 2018
PMID: 29542279Meta-AnalysisFull text (PMC)
The Efficacy and Safety of Megestrol Acetate in Protein-Energy Wasting due to Chronic Kidney Disease: A Systematic Review.
Wazny Lori D, Nadurak Stewart, Orsulak Cali et al. · J Ren Nutr · 2016
PMID: 26776251Meta-Analysis
Megestrol acetate for treatment of anorexia-cachexia syndrome.
Ruiz Garcia Vicente, López-Briz Eduardo, Carbonell Sanchis Rafael et al. · Cochrane Database Syst Rev · 2013
PMID: 23543530Meta-AnalysisFull text (PMC)
Effects of megestrol acetate in patients with cancer anorexia-cachexia syndrome--a systematic review and meta-analysis.
Leśniak Wiktoria, Bała Małgorzata, Jaeschke Roman et al. · Pol Arch Med Wewn · 2008
PMID: 19140567Meta-Analysis
Megestrol acetate for the treatment of anorexia-cachexia syndrome.
Berenstein E G, Ortiz Z · Cochrane Database Syst Rev · 2005
PMID: 15846706Meta-Analysis
Systematic review of megestrol acetate in the treatment of anorexia-cachexia syndrome.
Pascual López Antonio, Roqué i Figuls Marta, Urrútia Cuchi Gerard et al. · J Pain Symptom Manage · 2004
PMID: 15050664Meta-Analysis
[Megestrol acetate: a systematic review usefulness about the weight gain in neoplastic patients with cachexia].
Ruiz-García Vicente, Juan Oscar, Pérez Hoyos Santiago et al. · Med Clin (Barc) · 2002
PMID: 12200017Meta-Analysis
Mirtazapine versus megestrol acetate in treatment of anorexia-cachexia in advanced cancer patients: a randomized, double-blind trial.
Chowdhury Iftekhar Hossain, Rahman Md Sayedur, Chowdhury Md Najmul Kabir et al. · Jpn J Clin Oncol · 2024
PMID: 38323684RCT

Research data from MEDLINE/PubMed

Benefits & Expected Outcomes

Benefits, expected outcomes, efficacy data, and NNT (Number Needed to Treat) are pending physician authorship and evidence review.

Risks & Side Effects

Risk profile, common and serious adverse effects, contraindications, and drug interactions are pending physician authorship.

Related Symptoms

Symptoms associated with conditions this intervention addresses

No related symptoms have been mapped yet. Symptom linkages are derived through associated conditions.

Alternatives & Comparisons

Alternative treatments, comparison data, and clinical decision support are pending physician authorship.

Medical Disclaimer

This information is for educational purposes only and does not constitute medical advice, diagnosis, or treatment. Always consult with a qualified healthcare provider regarding any medical condition or treatment plan.

Do not start, stop, or change any treatment without consulting your healthcare provider.

Quick Facts

Type
Substance / Medication
Fully Specified Name
Megestrol acetate (substance)
SNOMED CT
126092000
UMLS CUI
C0065879

Clinical Data

This intervention maps to 2 entities in the Healos knowledge graph.

2
Conditions
0
Biomarkers
0
Specialists
0
Symptoms
5
Clinical Trials

Data is sourced from SNOMED CT, UMLS, and the Healos clinical knowledge graph. Content sections marked as pending require physician authorship. Consult a healthcare provider before starting any treatment.