Substance / Medication

Methocarbamol

Overview

Active Ingredient
methocarbamol
RxNorm CUI
6845

Indications

Methocarbamol is indicated as an adjunct to rest, physical therapy, and other measures for the relief of discomfort associated with acute, painful musculoskeletal conditions. The mode of action of methocarbamol has not been clearly identified, but may be related to its sedative properties. Methocarbamol does not directly relax tense skeletal muscles in man.

Labeler: Advanced Rx of Tennessee, LLCUpdated: 2026-02-18T00:00:00.000ZFull label on DailyMed

Contraindications

When this intervention should not be used

Methocarbamol is contraindicated in patients hypersensitive to methocarbamol or to any of the tablet components.

Indications & Related Conditions

Conditions associated via SNOMED clinical relationships

Administration & Protocol

Dosing, route, and treatment protocol

Detailed dosage and administration information is available in the full FDA drug label.

View full prescribing information on DailyMed

Monitoring & Follow-Up

Biomarkers relevant to this intervention via related conditions

No monitoring biomarkers have been mapped yet. Biomarker-intervention linkages are derived through related conditions and will expand as the knowledge graph grows.

Research Evidence

Published studies and systematic reviews

Sort:
Methocarbamol versus diazepam in acute low back pain in the emergency department: a randomised double-blind clinical trial.
Sharifi Meisam, Abdorazzaghnejad Ali, Yazdchi Mahtab et al. · Emerg Med J · 2023
PMID: 37068928RCT
Randomized-controlled trial of methocarbamol as a novel treatment for muscle cramps in cirrhotic patients.
Abd-Elsalam Sherief, Arafa Mona, Elkadeem Mahmoud et al. · Eur J Gastroenterol Hepatol · 2019
PMID: 30444744RCT
Efficacy of Methocarbamol for Acute Pain Management in Young Adults With Traumatic Rib Fractures.
Deloney Lindsay P, Smith Condeni Melanie, Carter Cassandra et al. · Ann Pharmacother · 2021
PMID: 33045839Observational
A Randomized, Double-Blind, Placebo-Controlled Trial of Naproxen With or Without Orphenadrine or Methocarbamol for Acute Low Back Pain.
Friedman Benjamin W, Cisewski David, Irizarry Eddie et al. · Ann Emerg Med · 2018
PMID: 29089169ObservationalFull text (PMC)
[Methocarbamol in acute low back pain. A randomized double-blind controlled study].
Emrich Oliver M D, Milachowski Klaus A, Strohmeier Martin · MMW Fortschr Med · 2015
PMID: 26168743Observational
Simultaneous determination of methocarbamol and ibuprofen or diclofenac potassium using mean centering of the ratio spectra method.
Ali Nouruddin Wageih, Hegazy Maha Ahamd, Abdelkawy Mohamed et al. · Acta Pharm · 2012
PMID: 22750817Observational

Research data from MEDLINE/PubMed

Benefits & Expected Outcomes

Benefits, expected outcomes, efficacy data, and NNT (Number Needed to Treat) are pending physician authorship and evidence review.

Risks & Side Effects

Adverse reaction and safety data for this drug is sourced from the FDA-approved label.

View adverse reactions & drug interactions on DailyMed

Related Symptoms

Symptoms associated with conditions this intervention addresses

No related symptoms have been mapped yet. Symptom linkages are derived through associated conditions.

Alternatives & Comparisons

Alternative treatments, comparison data, and clinical decision support are pending physician authorship.

Medical Disclaimer

This information is for educational purposes only and does not constitute medical advice, diagnosis, or treatment. Always consult with a qualified healthcare provider regarding any medical condition or treatment plan.

Do not start, stop, or change any treatment without consulting your healthcare provider.

Quick Facts

Type
Substance / Medication
Fully Specified Name
Methocarbamol (substance)
SNOMED CT
387486000
UMLS CUI
C0025659
RxNorm CUI
6845
Labeler
Advanced Rx of Tennessee, LLC

Clinical Data

This intervention maps to 3 entities in the Healos knowledge graph.

3
Conditions
0
Biomarkers
0
Specialists
0
Symptoms

Data is sourced from SNOMED CT, UMLS, and the Healos clinical knowledge graph. Content sections marked as pending require physician authorship. Consult a healthcare provider before starting any treatment.