Substance / Medication

Naproxen

Overview

Active Ingredient
naproxen
RxNorm CUI
7258

Indications

Naproxen tablets and naproxen sodium tablets are indicated for: the relief of the signs and symptoms of: Naproxen tablets and naproxen sodium tablets are also indicated for: the relief of signs and symptoms of: the management of: • rheumatoid arthritis • osteoarthritis • ankylosing spondylitis • Polyarticular Juvenile Idiopathic Arthritis • tendonitis • bursitis • acute gout • pain • primary dysmenorrhea

Labeler: A-S Medication SolutionsUpdated: 2026-01-30T00:00:00.000ZFull label on DailyMed

Boxed Warning

FDA Black Box Warning

Cardiovascular Thrombotic Events Gastrointestinal Bleeding, Ulceration, and Perforation • 5.1 see Warnings and Precautions () Nonsteroidal anti-inflammatory drugs (NSAIDs) cause an increased risk of serious cardiovascular thrombotic events, including myocardial infarction and stroke, which can be fa

Contraindications

When this intervention should not be used

Naproxen tablets and naproxen sodium tablets are contraindicated in the following patients: • 5.7 5.9 see Warnings and Precautions (,) Known hypersensitivity (e.g., anaphylactic reactions and serious skin reactions) to naproxen or any components of the drug product [] • 5.7 5.8 see Warnings and Prec

Indications & Related Conditions

Conditions associated via SNOMED clinical relationships

Administration & Protocol

Dosing, route, and treatment protocol

Detailed dosage and administration information is available in the full FDA drug label.

View full prescribing information on DailyMed

Monitoring & Follow-Up

Biomarkers relevant to this intervention via related conditions

Clinical Trials

54 trials linked to this intervention

54
Total Trials
7
Recruiting
32
With Results

Research Evidence

Published studies and systematic reviews

Sort:
A randomized controlled trial of add-on naproxen, simvastatin and their combination for the treatment of schizophrenia or schizoaffective disorder.
Weiser Mark, Levi Linda, Park Jinyoung et al. · Eur Neuropsychopharmacol · 2023
PMID: 37126871Meta-Analysis
Naproxen for the treatment of neoplastic fever: A PRISMA-compliant systematic review and meta-analysis.
Zhang Hongliang, Wu Yuyong, Lin Zhongqiu et al. · Medicine (Baltimore) · 2019
PMID: 31145329Meta-AnalysisFull text (PMC)
Efficacy of naproxen prophylaxis for the prevention of heterotopic ossification after hip surgery: a meta-analysis.
Ma Ran, Chen Guan-Hong, Zhao Liu-Jing et al. · J Orthop Surg Res · 2018
PMID: 29506541Meta-AnalysisFull text (PMC)
Sumatriptan plus naproxen for the treatment of acute migraine attacks in adults.
Law Simon, Derry Sheena, Moore R Andrew · Cochrane Database Syst Rev · 2016
PMID: 27096438Meta-AnalysisFull text (PMC)
Sumatriptan plus naproxen for acute migraine attacks in adults.
Law Simon, Derry Sheena, Moore R Andrew · Cochrane Database Syst Rev · 2013
PMID: 24142431Meta-Analysis
Naproxen with or without an antiemetic for acute migraine headaches in adults.
Law Simon, Derry Sheena, Moore R Andrew · Cochrane Database Syst Rev · 2013
PMID: 24142263Meta-AnalysisFull text (PMC)
Meta-analysis of the efficacy and safety of naproxen sodium in the acute treatment of migraine.
Suthisisang Chuthamanee C, Poolsup Nalinee, Suksomboon Naeti et al. · Headache · 2010
PMID: 20236345Meta-Analysis
Single dose oral naproxen and naproxen sodium for acute postoperative pain in adults.
Derry Christopher, Derry Sheena, Moore R Andrew et al. · Cochrane Database Syst Rev · 2009
PMID: 19160232Meta-AnalysisFull text (PMC)
Single dose oral naproxen and naproxen sodium for acute postoperative pain.
Mason L, Edwards J E, Moore R A et al. · Cochrane Database Syst Rev · 2004
PMID: 15495091Meta-AnalysisFull text (PMC)
A look at the safety profile of over-the-counter naproxen sodium: a meta-analysis.
Bansal V, Dex T, Proskin H et al. · J Clin Pharmacol · 2001
PMID: 11210392Meta-Analysis

Research data from MEDLINE/PubMed

Benefits & Expected Outcomes

Benefits, expected outcomes, efficacy data, and NNT (Number Needed to Treat) are pending physician authorship and evidence review.

Risks & Side Effects

Adverse reaction and safety data for this drug is sourced from the FDA-approved label.

View adverse reactions & drug interactions on DailyMed

Related Symptoms

Symptoms associated with conditions this intervention addresses

No related symptoms have been mapped yet. Symptom linkages are derived through associated conditions.

Alternatives & Comparisons

Alternative treatments, comparison data, and clinical decision support are pending physician authorship.

Medical Disclaimer

This information is for educational purposes only and does not constitute medical advice, diagnosis, or treatment. Always consult with a qualified healthcare provider regarding any medical condition or treatment plan.

Do not start, stop, or change any treatment without consulting your healthcare provider.

Specialists

Providers who commonly manage this intervention

Health Goals

Goals connected through associated conditions

Quick Facts

Type
Substance / Medication
Fully Specified Name
Naproxen (substance)
SNOMED CT
372588000
UMLS CUI
C0027396
RxNorm CUI
7258
Labeler
A-S Medication Solutions

Clinical Data

This intervention maps to 14 entities in the Healos knowledge graph.

9
Conditions
2
Biomarkers
1
Specialists
0
Symptoms
54
Clinical Trials

Data is sourced from SNOMED CT, UMLS, and the Healos clinical knowledge graph. Content sections marked as pending require physician authorship. Consult a healthcare provider before starting any treatment.

Naproxen — Conditions, Biomarkers & Specialists | Healos | Ltrl