Substance / Medication

Niclosamide

SNOMED 387334008 UMLS C0028017

Overview

Active Ingredient

niclosamide

RxNorm CUI

7402

Indications & Related Conditions

Conditions associated via SNOMED clinical relationships

Helminth infection

Administration & Protocol

Dosing, route, and treatment protocol

Administration details including route, dosing schedules, preparation instructions, and contraindications are pending physician authorship.

Monitoring & Follow-Up

Biomarkers relevant to this intervention via related conditions

No monitoring biomarkers have been mapped yet. Biomarker-intervention linkages are derived through related conditions and will expand as the knowledge graph grows.

Clinical Trials

1 trials linked to this intervention

Total Trials

Recruiting

With Results

Recent Trials

Randomized-controlled Trial of the Effectiveness of COVID-19 Early Treatment in Community

NCT05087381Phase 4Completed1200 enrolled

View all 1 trials on ClinicalTrials.gov

Research Evidence

Published studies and systematic reviews

Sort:

Niclosamide as a Promising Therapeutic Player in Human Cancer and Other Diseases.

Wang Zhan, Ren Junyi, Du Jinxiu et al. · Int J Mol Sci · 2022

PMID: 36555754Meta-AnalysisFull text (PMC)

A randomized, double-blind, placebo-controlled trial of niclosamide nanohybrid for the treatment of patients with mild to moderate COVID-19.

Kim Jung Ho, Kym Sungmin, Kim Shin-Woo et al. · Nat Commun · 2025

PMID: 40750596RCTFull text (PMC)

Clinical safety and pharmacokinetics of a novel oral niclosamide formulation compared with marketed niclosamide chewing tablets in healthy volunteers: A three-part randomized, double-blind, placebo-controlled trial.

Walther Niklas, Schultz-Heienbrok Robert, Staß Heino et al. · PLoS One · 2025

PMID: 39999124RCTFull text (PMC)

Prophylaxis for renal patients at risk of COVID-19 infection: results from the intranasal niclosamide randomised, double blinded, placebo controlled arm of the PROTECT-V platform trial.

Humphrey Toby J L, Qian Wendi, Chen-Xu Michael et al. · BMC Infect Dis · 2025

PMID: 39934669RCTFull text (PMC)

A randomized trial to assess the acceleration of viral clearance by the combination Favipiravir/Ivermectin/Niclosamide in mild-to-moderate COVID-19 adult patients (FINCOV).

Siripongboonsitti Taweegrit, Tawinprai Kriangkrai, Avirutnan Panisadee et al. · J Infect Public Health · 2024

PMID: 38569269RCT

Efficacy of Niclosamide vs Placebo in SARS-CoV-2 Respiratory Viral Clearance, Viral Shedding, and Duration of Symptoms Among Patients With Mild to Moderate COVID-19: A Phase 2 Randomized Clinical Trial.

Cairns Dana M, Dulko Dorothy, Griffiths Jeffrey K et al. · JAMA Netw Open · 2022

PMID: 35138402RCTFull text (PMC)

Niclosamide as an adjuvant to etanercept in treatment patients with active rheumatoid arthritis: an 8-week randomized controlled pilot study.

Al-Gareeb Ali Ismail A, Gorial Faiq Isho, Mahmood Ahmed S · Clin Rheumatol · 2018

PMID: 29882203RCT

The efficacy of the supramolecular complexes of niclosamide obtained by mechanochemical technology and targeted delivery against cestode infection of animals.

Arkhipov Ivan A, Sadov Konstantin M, Limova Yulia V et al. · Vet Parasitol · 2017

PMID: 28969776RCT

[Studies on spray of niclosamide ethanolamine salt II observation on prevention of Schistosoma japonicum infection in bovine].

Dai Jian-Rong, Xing Yun-Tian, Li Hong-Jun et al. · Zhongguo Xue Xi Chong Bing Fang Zhi Za Zhi · 2012

PMID: 23593829RCT

Comparison of Solid Self-Nanoemulsifying Systems and Surface-Coated Microspheres: Improving Oral Bioavailability of Niclosamide.

Baek Kyungho, Woo Mi Ran, Ud Din Fakhar et al. · Int J Nanomedicine · 2024

PMID: 39735329ObservationalFull text (PMC)

Research data from MEDLINE/PubMed

Benefits & Expected Outcomes

Benefits, expected outcomes, efficacy data, and NNT (Number Needed to Treat) are pending physician authorship and evidence review.

Risks & Side Effects

Risk profile, common and serious adverse effects, contraindications, and drug interactions are pending physician authorship.

Related Symptoms

Symptoms associated with conditions this intervention addresses

No related symptoms have been mapped yet. Symptom linkages are derived through associated conditions.

Alternatives & Comparisons

Alternative treatments, comparison data, and clinical decision support are pending physician authorship.

Medical Disclaimer

This information is for educational purposes only and does not constitute medical advice, diagnosis, or treatment. Always consult with a qualified healthcare provider regarding any medical condition or treatment plan.

Do not start, stop, or change any treatment without consulting your healthcare provider.

Quick Facts

Type: Substance / Medication
Fully Specified Name: Niclosamide (substance)
SNOMED CT: 387334008
UMLS CUI: C0028017
RxNorm CUI: 7402

Clinical Data

This intervention maps to 1 entities in the Ltrl knowledge graph.

Conditions

Biomarkers

Specialists

Symptoms

Clinical Trials

Data is sourced from SNOMED CT, UMLS, and the Ltrl clinical knowledge graph. Content sections marked as pending require physician authorship. Consult a healthcare provider before starting any treatment.