Substance / Medication

Nicotine

Overview

Active Ingredient
nicotine
RxNorm CUI
7407

Indications

NICOTROL NS is indicated as an aid to smoking cessation for the relief of nicotine withdrawal symptoms. NICOTROL NS therapy should be used as a part of a comprehensive behavioral smoking cessation program. The safety and efficacy of the continued use of NICOTROL NS for periods longer than 6 months have not been adequately studied and such use is not recommended.

Labeler: Pharmacia & Upjohn Company LLCUpdated: 2025-05-29T00:00:00.000ZFull label on DailyMed

Contraindications

When this intervention should not be used

Use of NICOTROL NS therapy is contraindicated in patients with known hypersensitivity or allergy to nicotine or to any component of the product.

Indications & Related Conditions

Conditions associated via SNOMED clinical relationships

Administration & Protocol

Dosing, route, and treatment protocol

Detailed dosage and administration information is available in the full FDA drug label.

View full prescribing information on DailyMed

Monitoring & Follow-Up

Biomarkers relevant to this intervention via related conditions

Clinical Trials

169 trials linked to this intervention

169
Total Trials
46
Recruiting
58
With Results

Research Evidence

Published studies and systematic reviews

Sort:
Nicotine as target-therapy in Sleep-Related Hypermotor Epilepsy due to nAChR genes mutation: case report and systematic review of literature.
Tiscornia Maddalena, Bosisio Luca, Torta Francesca et al. · Sleep Med · 2026
PMID: 41192108Meta-Analysis
Cannabis and nicotine/tobacco co-use and its association with cognitive and neural outcomes: A systematic review.
Yeap Zac J S, Argote Mathilde, Nadler Emma et al. · Neurosci Biobehav Rev · 2026
PMID: 41265541Meta-Analysis
Weaning From Tobacco with Nicotine or Varenicline in Severe and Mild Tobacco Dependence—Findings of a Meta-Analysis.
Selbach Claudia, Siebel Christian, Lilienthal Jona et al. · Dtsch Arztebl Int · 2025
PMID: 39628402Meta-AnalysisFull text (PMC)
Analysis of Assessment Methods for Detecting Nicotine Residue and Its Impact on Humans: A Systematic Review.
Almassi Audrey A, Oliver Brian G G, Smith Sheree M · Int J Environ Res Public Health · 2025
PMID: 40283845Meta-AnalysisFull text (PMC)
Nicotine replacement therapy as a smoking cessation tool for adolescents: an update.
Beis Ioannis, Dimou Anastasios, Kotoulas Serafeim-Chrysovalantis et al. · Front Psychiatry · 2025
PMID: 40071276Meta-AnalysisFull text (PMC)
Estimating human pharmacokinetic parameters for electronic nicotine delivery system products from chemical analyses of their aerosols.
Shiffman Saul, Cohen Gal, Liang Qiwei et al. · Drug Test Anal · 2025
PMID: 38808532Meta-Analysis
The Effects of Thirdhand Vape Residue from Nicotine and Non-Nicotine Vapes on Cells: A Systematic Review.
Stracci Jazzlin Marie Adele, Ganesan Alyssa Priyanka, Pitogo Prescious Grace et al. · Int J Environ Res Public Health · 2025
PMID: 40283694Meta-AnalysisFull text (PMC)
Assessing Nicotine Pharmacokinetics of New-Generation Tobacco Products and Conventional Cigarettes: A Systematic Review and Meta-analysis.
Cao Yue, Liu Xinru, Hu Zhongyi et al. · Nicotine Tob Res · 2025
PMID: 39162577Meta-Analysis
The role of sweet/fruit-flavored disposable electronic cigarettes on early nicotine initiation - a systematic review.
Kopa-Stojak Paulina Natalia, Pawliczak Rafal · BMC Public Health · 2025
PMID: 39962478Meta-AnalysisFull text (PMC)
Oral nicotine pouches for cessation or reduction of use of other tobacco or nicotine products.
Hartmann-Boyce Jamie, Tattan-Birch Harry, Brown Jamie et al. · Cochrane Database Syst Rev · 2025
PMID: 39945317Meta-AnalysisFull text (PMC)

Research data from MEDLINE/PubMed

Benefits & Expected Outcomes

Benefits, expected outcomes, efficacy data, and NNT (Number Needed to Treat) are pending physician authorship and evidence review.

Risks & Side Effects

Adverse reaction and safety data for this drug is sourced from the FDA-approved label.

View adverse reactions & drug interactions on DailyMed

Related Symptoms

Symptoms associated with conditions this intervention addresses

No related symptoms have been mapped yet. Symptom linkages are derived through associated conditions.

Alternatives & Comparisons

Alternative treatments, comparison data, and clinical decision support are pending physician authorship.

Medical Disclaimer

This information is for educational purposes only and does not constitute medical advice, diagnosis, or treatment. Always consult with a qualified healthcare provider regarding any medical condition or treatment plan.

Do not start, stop, or change any treatment without consulting your healthcare provider.

Quick Facts

Type
Substance / Medication
Fully Specified Name
Nicotine (substance)
SNOMED CT
68540007
UMLS CUI
C0028040
RxNorm CUI
7407
Labeler
Pharmacia & Upjohn Company LLC

Clinical Data

This intervention maps to 3 entities in the Healos knowledge graph.

2
Conditions
1
Biomarkers
0
Specialists
0
Symptoms
169
Clinical Trials

Data is sourced from SNOMED CT, UMLS, and the Healos clinical knowledge graph. Content sections marked as pending require physician authorship. Consult a healthcare provider before starting any treatment.

Nicotine — Conditions, Biomarkers & Specialists | Healos | Ltrl