Substance / Medication

Pegvisomant

Overview

Active Ingredient
pegvisomant
RxNorm CUI
278739

Indications & Related Conditions

Conditions associated via SNOMED clinical relationships

Administration & Protocol

Dosing, route, and treatment protocol

Administration details including route, dosing schedules, preparation instructions, and contraindications are pending physician authorship.

Monitoring & Follow-Up

Biomarkers relevant to this intervention via related conditions

No monitoring biomarkers have been mapped yet. Biomarker-intervention linkages are derived through related conditions and will expand as the knowledge graph grows.

Clinical Trials

7 trials linked to this intervention

7
Total Trials
0
Recruiting
2
With Results

Research Evidence

Published studies and systematic reviews

Sort:
Second line treatment of acromegaly: Pasireotide or Pegvisomant?
Chiloiro Sabrina, Bianchi Antonio, Giampietro Antonella et al. · Best Pract Res Clin Endocrinol Metab · 2022
PMID: 35931640Meta-Analysis
Combined therapy of somatostatin analogues with pegvisomant for the treatment of acromegaly: a meta-analysis of prospective studies.
Ma Lingyun, Luo Daohuang, Yang Ting et al. · BMC Endocr Disord · 2020
PMID: 32811475Meta-AnalysisFull text (PMC)
Effectiveness and safety of pegvisomant: a systematic review and meta-analysis of observational longitudinal studies.
Leonart Letícia P, Tonin Fernanda S, Ferreira Vinicius L et al. · Endocrine · 2019
PMID: 30145746Meta-Analysis
Pegvisomant Improves Glucose Metabolism in Acromegaly: A Meta-Analysis of Prospective Interventional Studies.
Feola Tiziana, Cozzolino Alessia, Simonelli Ilaria et al. · J Clin Endocrinol Metab · 2019
PMID: 30869797Meta-Analysis
The Effect of the Exon-3-Deleted Growth Hormone Receptor on Pegvisomant-Treated Acromegaly: A Systematic Review and Meta-Analysis.
Franck Sanne E, Broer Linda, van der Lely Aart Jan et al. · Neuroendocrinology · 2017
PMID: 27513761Meta-AnalysisFull text (PMC)
Long-term treatment with pegvisomant: observations from 2090 acromegaly patients in ACROSTUDY.
Buchfelder Michael, van der Lely Aart-Jan, Biller Beverly M K et al. · Eur J Endocrinol · 2018
PMID: 30325178RCT
Effective combination treatment with cabergoline and low-dose pegvisomant in active acromegaly: a prospective clinical trial.
Higham C E, Atkinson A B, Aylwin S et al. · J Clin Endocrinol Metab · 2012
PMID: 22278424RCT
Cotreatment with pegvisomant and a somatostatin analog (SA) in SA-responsive acromegalic patients.
Madsen Michael, Poulsen Per L, Orskov Hans et al. · J Clin Endocrinol Metab · 2011
PMID: 21632808RCT
Quality of life in acromegalic patients during long-term somatostatin analog treatment with and without pegvisomant.
Neggers S J C M M, van Aken M O, de Herder W W et al. · J Clin Endocrinol Metab · 2008
PMID: 18647806RCT

Research data from MEDLINE/PubMed

Benefits & Expected Outcomes

Benefits, expected outcomes, efficacy data, and NNT (Number Needed to Treat) are pending physician authorship and evidence review.

Risks & Side Effects

Risk profile, common and serious adverse effects, contraindications, and drug interactions are pending physician authorship.

Related Symptoms

Symptoms associated with conditions this intervention addresses

No related symptoms have been mapped yet. Symptom linkages are derived through associated conditions.

Alternatives & Comparisons

Alternative treatments, comparison data, and clinical decision support are pending physician authorship.

Medical Disclaimer

This information is for educational purposes only and does not constitute medical advice, diagnosis, or treatment. Always consult with a qualified healthcare provider regarding any medical condition or treatment plan.

Do not start, stop, or change any treatment without consulting your healthcare provider.

Quick Facts

Type
Substance / Medication
Fully Specified Name
Pegvisomant (substance)
SNOMED CT
409201000
UMLS CUI
C0913469
RxNorm CUI
278739

Clinical Data

This intervention maps to 1 entities in the Healos knowledge graph.

1
Conditions
0
Biomarkers
0
Specialists
0
Symptoms
7
Clinical Trials

Data is sourced from SNOMED CT, UMLS, and the Healos clinical knowledge graph. Content sections marked as pending require physician authorship. Consult a healthcare provider before starting any treatment.