Substance / Medication

Ponesimod

Overview

Active Ingredient
ponesimod
RxNorm CUI
2532300

Indications

PONVORY is indicated for the treatment of relapsing forms of multiple sclerosis (MS), to include clinically isolated syndrome, relapsing-remitting disease, and active secondary progressive disease, in adults.

Labeler: Vanda Pharmaceuticals Inc.Updated: 2025-12-04T00:00:00.000ZFull label on DailyMed

Contraindications

When this intervention should not be used

PONVORY is contraindicated in patients who: 5.2 [see Warnings and Precautions ()] In the last 6 months, have experienced myocardial infarction, unstable angina, stroke, transient ischemic attack (TIA), decompensated heart failure requiring hospitalization, or Class III or IV heart failure 5.2 [see W

Indications & Related Conditions

Conditions associated via SNOMED clinical relationships

Administration & Protocol

Dosing, route, and treatment protocol

Detailed dosage and administration information is available in the full FDA drug label.

View full prescribing information on DailyMed

Monitoring & Follow-Up

Biomarkers relevant to this intervention via related conditions

No monitoring biomarkers have been mapped yet. Biomarker-intervention linkages are derived through related conditions and will expand as the knowledge graph grows.

Clinical Trials

59 trials linked to this intervention

59
Total Trials
13
Recruiting
25
With Results

Research Evidence

Published studies and systematic reviews

Sort:
A Randomized Trial on the Combined Effect of Ponesimod and Propranolol on Heart Rate, Cardiac Safety, and Pharmacokinetics in Healthy Adults.
Ouwerkerk-Mahadevan Sivi, Hosman Tessa, Poggesi Italo et al. · Clin Transl Sci · 2025
PMID: 40913391RCTFull text (PMC)
Efficacy and Safety of Ponesimod Compared with Teriflunomide in Female Patients with Relapsing Multiple Sclerosis: Findings from the Pivotal OPTIMUM Study.
Jones Robyn R, Turkoz Ibrahim, Ait-Tihyaty Maria et al. · J Womens Health (Larchmt) · 2024
PMID: 38301149RCT
Modeling clinical efficacy of the S1P receptor modulator ponesimod in psoriasis.
Krause Andreas, D'Ambrosio Daniele, Dingemanse Jasper · J Dermatol Sci · 2018
PMID: 29174115RCT
Effects of multiple-dose ponesimod, a selective S1Preceptor modulator, on lymphocyte subsets in healthy humans.
Jurcevic Stipo, Juif Pierre-Eric, Hamid Colleen et al. · Drug Des Devel Ther · 2017
PMID: 28096659RCTFull text (PMC)
Mitigation of Initial Cardiodynamic Effects of the S1PReceptor Modulator Ponesimod Using a Novel Up-Titration Regimen.
Juif Pierre-Eric, Hoch Matthias, Vaclavkova Andrea et al. · J Clin Pharmacol · 2017
PMID: 27558098RCT
Biocomparison of Three Formulations of the S1P1 Receptor Modulator Ponesimod in Healthy Subjects.
Juif Pierre-Eric, Hoch Matthias, D'Ambrosio Daniele et al. · Drugs R D · 2015
PMID: 25939333RCTFull text (PMC)
Differential effects of ponesimod, a selective S1P1 receptor modulator, on blood-circulating human T cell subpopulations.
D'Ambrosio Daniele, Steinmann Jörg, Brossard Patrick et al. · Immunopharmacol Immunotoxicol · 2015
PMID: 25519470RCT

Research data from MEDLINE/PubMed

Benefits & Expected Outcomes

Benefits, expected outcomes, efficacy data, and NNT (Number Needed to Treat) are pending physician authorship and evidence review.

Risks & Side Effects

Adverse reaction and safety data for this drug is sourced from the FDA-approved label.

View adverse reactions & drug interactions on DailyMed

Related Symptoms

Symptoms associated with conditions this intervention addresses

No related symptoms have been mapped yet. Symptom linkages are derived through associated conditions.

Alternatives & Comparisons

Alternative treatments, comparison data, and clinical decision support are pending physician authorship.

Medical Disclaimer

This information is for educational purposes only and does not constitute medical advice, diagnosis, or treatment. Always consult with a qualified healthcare provider regarding any medical condition or treatment plan.

Do not start, stop, or change any treatment without consulting your healthcare provider.

Quick Facts

Type
Substance / Medication
Fully Specified Name
Ponesimod (substance)
SNOMED CT
1179253008
UMLS CUI
C2934701
RxNorm CUI
2532300
Labeler
Vanda Pharmaceuticals Inc.

Clinical Data

This intervention maps to 1 entities in the Healos knowledge graph.

1
Conditions
0
Biomarkers
0
Specialists
0
Symptoms
59
Clinical Trials

Data is sourced from SNOMED CT, UMLS, and the Healos clinical knowledge graph. Content sections marked as pending require physician authorship. Consult a healthcare provider before starting any treatment.