Substance / Medication

Potassium citrate

Overview

Active Ingredient
potassium citrate
RxNorm CUI
54993

Indications

Tricitrates oral solution is an effective alkalinizing agent useful in those conditions where long-term maintenance of an alkaline urine is desirable, such as in patients with uric acid and cystine calculi of the urinary tract. In addition, it is a valuable adjuvant when administered with uricosuric agents in gout therapy, since urates tend to crystallize out of an acid urine. It is also effective in correcting the acidosis of certain renal tubular disorders. This product is highly concentrated,

Labeler: Chartwell Governmental & Specialty RX, LLC.Updated: 2026-02-25T00:00:00.000ZFull label on DailyMed

Contraindications

When this intervention should not be used

Severe renal impairment with oliguria or azotemia, untreated Addison's disease, or severe myocardial damage. In certain situations, when patients are on a sodium-restricted diet, the use of potassium citrate may be preferable; or, when patients are on a potassium-restricted diet, the use of sodium c

Indications & Related Conditions

Conditions associated via SNOMED clinical relationships

Administration & Protocol

Dosing, route, and treatment protocol

Detailed dosage and administration information is available in the full FDA drug label.

View full prescribing information on DailyMed

Monitoring & Follow-Up

Biomarkers relevant to this intervention via related conditions

Research Evidence

Published studies and systematic reviews

Sort:
Effect of potassium citrate supplement on stone recurrence before or after lithotripsy: systematic review and meta-analysis.
Carvalho Maurício, Erbano Bruna Olandoski, Kuwaki Eduardo Yukio et al. · Urolithiasis · 2017
PMID: 27915395Meta-Analysis
Does potassium citrate administration change the type and composition of encrusted material on Double-J stent compared to primary stone?
Mohammadi Abdolreza, Rakebi Mohammad Mehdi, Gholamnezhad Maryam et al. · Int Urol Nephrol · 2021
PMID: 34050877RCTFull text (PMC)
Potassium citrate and metabolic acidosis in children with epilepsy on the ketogenic diet: a prospective controlled study.
Bjurulf Björn, Magnus Per, Hallböök Tove et al. · Dev Med Child Neurol · 2020
PMID: 31745987RCT
Impact of Potassium Citrate vs Citric Acid on Urinary Stone Risk in Calcium Phosphate Stone Formers.
Doizi Steeve, Poindexter John R, Pearle Margaret S et al. · J Urol · 2018
PMID: 30036516RCTFull text (PMC)
Effects of potassium citrate or potassium chloride in patients with combined glucose intolerance: A placebo-controlled pilot study.
Conen Katrin, Scanni Roberto, Gombert Marie-Therese et al. · J Diabetes Complications · 2016
PMID: 27260862RCT

Research data from MEDLINE/PubMed

Benefits & Expected Outcomes

Benefits, expected outcomes, efficacy data, and NNT (Number Needed to Treat) are pending physician authorship and evidence review.

Risks & Side Effects

Adverse reaction and safety data for this drug is sourced from the FDA-approved label.

View adverse reactions & drug interactions on DailyMed

Related Symptoms

Symptoms associated with conditions this intervention addresses

No related symptoms have been mapped yet. Symptom linkages are derived through associated conditions.

Alternatives & Comparisons

Alternative treatments, comparison data, and clinical decision support are pending physician authorship.

Medical Disclaimer

This information is for educational purposes only and does not constitute medical advice, diagnosis, or treatment. Always consult with a qualified healthcare provider regarding any medical condition or treatment plan.

Do not start, stop, or change any treatment without consulting your healthcare provider.

Health Goals

Goals connected through associated conditions

Quick Facts

Type
Substance / Medication
Fully Specified Name
Potassium citrate (substance)
SNOMED CT
387450001
UMLS CUI
C0137996
RxNorm CUI
54993
Labeler
Chartwell Governmental & Specialty RX, LLC.

Clinical Data

This intervention maps to 8 entities in the Ltrl knowledge graph.

2
Conditions
3
Biomarkers
2
Specialists
0
Symptoms

Data is sourced from SNOMED CT, UMLS, and the Ltrl clinical knowledge graph. Content sections marked as pending require physician authorship. Consult a healthcare provider before starting any treatment.