Substance / Medication

Pralidoxime

SNOMED 387527005 UMLS C0071808

Overview

Active Ingredient

pralidoxime

RxNorm CUI

34345

Indications & Related Conditions

Conditions associated via SNOMED clinical relationships

Poisoning by drug AND/OR medicinal substance

Poisoning

Administration & Protocol

Dosing, route, and treatment protocol

Administration details including route, dosing schedules, preparation instructions, and contraindications are pending physician authorship.

Monitoring & Follow-Up

Biomarkers relevant to this intervention via related conditions

No monitoring biomarkers have been mapped yet. Biomarker-intervention linkages are derived through related conditions and will expand as the knowledge graph grows.

Clinical Trials

2 trials linked to this intervention

Total Trials

Recruiting

With Results

Recent Trials

Glucagon's Cardiovascular Effects With and Without Beta-blocker-induced Cardioinhibition

NCT03533179Phase 4Completed10 enrolled

Activated CHARcoal in Poisoned Patient - Pilot Trial

NCT05471479Phase 4Recruiting100 enrolled

View all 2 trials on ClinicalTrials.gov

Research Evidence

Published studies and systematic reviews

Sort:

Clinical study of continuous micropump infusion of atropine and pralidoxime chloride for treatment of severe acute organophosphorus insecticide poisoning.

Liu Hong-Xiang, Liu Chang-Fang, Yang Wan-Hua · J Chin Med Assoc · 2015

PMID: 26441220RCT

Reactivation of plasma butyrylcholinesterase by pralidoxime chloride in patients poisoned by WHO class II toxicity organophosphorus insecticides.

Konickx Lisa A, Worek Franz, Jayamanne Shaluka et al. · Toxicol Sci · 2013

PMID: 24052565RCTFull text (PMC)

Pharmacokinetic analysis of pralidoxime after its intramuscular injection alone or in combination with atropine-avizafone in healthy volunteers.

Abbara C, Rousseau J M, Lelièvre B et al. · Br J Pharmacol · 2010

PMID: 20804498RCTFull text (PMC)

Pralidoxime in acute organophosphorus insecticide poisoning--a randomised controlled trial.

Eddleston Michael, Eyer Peter, Worek Franz et al. · PLoS Med · 2009

PMID: 19564902RCTFull text (PMC)

Continuous pralidoxime infusion versus repeated bolus injection to treat organophosphorus pesticide poisoning: a randomised controlled trial.

Pawar Kirti S, Bhoite Ramesh R, Pillay Chandrakant P et al. · Lancet · 2006

PMID: 17174705RCT

Efficacy Assessment of an Uncharged Reactivator of NOP-Inhibited Acetylcholinesterase Based on Tetrahydroacridine Pyridine-Aldoxime Hybrid in Mouse Compared to Pralidoxime.

Calas André-Guilhem, Hanak Anne-Sophie, Jaffré Nina et al. · Biomolecules · 2020

PMID: 32512884ObservationalFull text (PMC)

A novel high-performance liquid chromatography with diode array detector method for the simultaneous quantification of the enzyme-reactivating oximes obidoxime, pralidoxime, and HI-6 in human plasma.

Kranawetvogl Tamara, Steinritz Dirk, Thiermann Horst et al. · Drug Test Anal · 2020

PMID: 32267631Observational

In silico and in vitro evaluation of two novel oximes (K378 and K727) in comparison to K-27 and pralidoxime against paraoxon-ethyl intoxication.

Arshad Maria, Fatmi Muhammad Qaiser, Musilek Kamil et al. · Toxicol Mech Methods · 2018

PMID: 28722512Observational

Superior efficacy of HI-6 dimethanesulfonate over pralidoxime methylsulfate against Russian VX poisoning in cynomolgus monkeys (Macaca fascicularis).

Reymond Chloé, Jaffré Nina, Taudon Nicolas et al. · Toxicology · 2018

PMID: 30218682Observational

Development and validation of a reverse phase liquid chromatography method for the simultaneous quantification of eserine and pralidoxime chloride in drugs-in-adhesive matrix type transdermal patches.

Banerjee S, Chattopadhyay P, Ghosh A et al. · Drug Res (Stuttg) · 2013

PMID: 23633237Observational

Research data from MEDLINE/PubMed

Benefits & Expected Outcomes

Benefits, expected outcomes, efficacy data, and NNT (Number Needed to Treat) are pending physician authorship and evidence review.

Risks & Side Effects

Risk profile, common and serious adverse effects, contraindications, and drug interactions are pending physician authorship.

Related Symptoms

Symptoms associated with conditions this intervention addresses

No related symptoms have been mapped yet. Symptom linkages are derived through associated conditions.

Alternatives & Comparisons

Alternative treatments, comparison data, and clinical decision support are pending physician authorship.

Medical Disclaimer

This information is for educational purposes only and does not constitute medical advice, diagnosis, or treatment. Always consult with a qualified healthcare provider regarding any medical condition or treatment plan.

Do not start, stop, or change any treatment without consulting your healthcare provider.

Quick Facts

Type: Substance / Medication
Fully Specified Name: Pralidoxime (substance)
SNOMED CT: 387527005
UMLS CUI: C0071808
RxNorm CUI: 34345

Clinical Data

This intervention maps to 2 entities in the Healos knowledge graph.

Conditions

Biomarkers

Specialists

Symptoms

Clinical Trials

Data is sourced from SNOMED CT, UMLS, and the Healos clinical knowledge graph. Content sections marked as pending require physician authorship. Consult a healthcare provider before starting any treatment.